Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Emilia Caselli"'
Autor:
Peggy Lu, Francesco Alletto, Bosul Lee, Elizabeth Burk, Jasmine Martinez, Fabio Prati, Emilia Caselli, Brad Spellberg, Brian Luna
Publikováno v:
PLoS ONE, Vol 18, Iss 6, p e0287102 (2023)
Recently, we reported rifabutin hyper-activity against Acinetobacter baumannii. We sought to characterize if any additional rifamycins (n = 22) would also display hyper-activity when tested in iron-limited media against A. baumannii, K. pneumoniae, a
Externí odkaz:
https://doaj.org/article/ad60d1ef5d15411eb99a26636e488cc0
Autor:
Maria Luisa Introvigne, Trevor J. Beardsley, Micah C. Fernando, David A. Leonard, Bradley J. Wallar, Susan D. Rudin, Magdalena A. Taracila, Philip N. Rather, Jennifer M. Colquhoun, Shaina Song, Francesco Fini, Kristine M. Hujer, Andrea M. Hujer, Fabio Prati, Rachel A. Powers, Robert A. Bonomo, Emilia Caselli
Publikováno v:
Antibiotics, Vol 12, Iss 4, p 644 (2023)
Acinetobacter baumannii is a Gram-negative organism listed as an urgent threat pathogen by the World Health Organization (WHO). Carbapenem-resistant A. baumannii (CRAB), especially, present therapeutic challenges due to complex mechanisms of resistan
Externí odkaz:
https://doaj.org/article/0bf39937c44f473185677dc4d7075b7e
Autor:
Tatsuya Ishikawa, Nayuta Furukawa, Emilia Caselli, Fabio Prati, Magdalena A. Taracila, Christopher R. Bethel, Yoshikazu Ishii, Akiko Shimizu-Ibuka, Robert A. Bonomo
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
The rise of multidrug resistant (MDR) Gram-negative bacteria has accelerated the development of novel inhibitors of class A and C β-lactamases. Presently, the search for novel compounds with new mechanisms of action is a clinical and scientific prio
Externí odkaz:
https://doaj.org/article/32eaf9b91e32478f8f3fd5a213b6b2f8
Autor:
Samuele Peppoloni, Eva Pericolini, Bruna Colombari, Diego Pinetti, Claudio Cermelli, Francesco Fini, Fabio Prati, Emilia Caselli, Elisabetta Blasi
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Pseudomonas aeruginosa is a Gram-negative nosocomial pathogen, often causative agent of severe device-related infections, given its great capacity to form biofilm. P. aeruginosa finely regulates the expression of numerous virulence factors, including
Externí odkaz:
https://doaj.org/article/dc14461cda4f4fa4b42eaaf71e00de45
Autor:
Melissa D. Barnes, Magdalena A. Taracila, Joseph D. Rutter, Christopher R. Bethel, Ioannis Galdadas, Andrea M. Hujer, Emilia Caselli, Fabio Prati, John P. Dekker, Krisztina M. Papp-Wallace, Shozeb Haider, Robert A. Bonomo
Publikováno v:
mBio, Vol 9, Iss 6 (2018)
ABSTRACT Pseudomonas aeruginosa produces a class C β-lactamase (e.g., PDC-3) that robustly hydrolyzes early generation cephalosporins often at the diffusion limit; therefore, bacteria possessing these β-lactamases are resistant to many β-lactam an
Externí odkaz:
https://doaj.org/article/edb8dbd7a6454ff080c0150b5085a0a8
Autor:
Scott T. Lefurgy, Emilia Caselli, Magdalena A. Taracila, Vladimir N. Malashkevich, Beena Biju, Krisztina M. Papp-Wallace, Jeffrey B. Bonanno, Fabio Prati, Steven C. Almo, Robert A. Bonomo
Publikováno v:
Biomolecules, Vol 10, Iss 5, p 671 (2020)
Boronic acid transition-state analog inhibitors (BATSIs) are partners with β-lactam antibiotics for the treatment of complex bacterial infections. Herein, microbiological, biochemical, and structural findings on four BATSIs with the FOX-4 cephamycin
Externí odkaz:
https://doaj.org/article/197e20aff7954e00a0784de10a5f4d91
Publikováno v:
ARKIVOC, Vol 2002, Iss 11, Pp 45-53 (2002)
Externí odkaz:
https://doaj.org/article/5218871294114e3bbd0054055f560d6d
Autor:
Tahani A. Alsenani, María Margarita Rodríguez, Barbara Ghiglione, Magdalena A. Taracila, Maria F. Mojica, Laura J. Rojas, Andrea M. Hujer, Gabriel Gutkind, Christopher R. Bethel, Philip N. Rather, Maria Luisa Introvigne, Fabio Prati, Emilia Caselli, Pablo Power, Focco van den Akker, Robert A. Bonomo
Publikováno v:
Antimicrobial Agents and Chemotherapy. 67
Design of novel β-lactamase inhibitors (BLIs) is one of the currently accepted strategies to combat the threat of cephalosporin and carbapenem resistance in Gram-negative bacteria. B oronic a cid t ransition s tate i nhibitors (BATSIs) are competiti
Autor:
Mattia Stucchi, Alessandro Zanni, Maria Luisa Introvigne, Francesco Fini, Emilia Caselli, Fabio Prati
Publikováno v:
Organicbiomolecular chemistry. 19(30)
A straightforward concise synthesis of chiral non-racemic aliphatic α-boryl isocyanides, relay intermediates for boron-based bioactive molecules in multicomponent reactions, is presented. The short synthetic sequence comprises as key steps copper-ca
Autor:
Sara J. Barlow, Robert A. Bonomo, Rachel A. Powers, Fabio Prati, Kali A. Smolen, Magdalena A. Taracila, Bradley J. Wallar, Emilia Caselli, Brandy N. Curtis
Publikováno v:
Antimicrob Agents Chemother
Extended-spectrum class C β-lactamases have evolved to rapidly inactivate expanded-spectrum cephalosporins, a class of antibiotics designed to be resistant to hydrolysis by β-lactamase enzymes. To better understand the mechanism by which A cinetoba