Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Emilia Arguello, A."'
Autor:
A. Emilia Arguello, Ang Li, Xuemeng Sun, Tanner W. Eggert, Elisabeth Mairhofer, Ralph E. Kleiner
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Kleiner and co-workers profile RNA 5-methylcytidine (m5C) dioxygenase enzymes using an activity-based metabolic probing strategy. They reveal ALKBH1 as the major 5-formylcytidine (f5C) writer and characterize modification sites across mRNA and tRNA.
Externí odkaz:
https://doaj.org/article/f9f2d08adb3846688a00f99d4bc761c2
Publikováno v:
Biochemical Society Transactions; Oct2024, Vol. 52 Issue 5, p2101-2112, 12p
Publikováno v:
ACS Chem Biol
Epitranscriptomic RNA modifications can regulate biological processes, but there remains a major gap in our ability to identify and measure individual modifications at nucleotide resolution. Here we present Mal-Seq, a chemical method to sequence 5-fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b42cafc9dd41bb640d150310af52b91f
https://doi.org/10.1021/acschembio.1c00707
https://doi.org/10.1021/acschembio.1c00707
Publikováno v:
Journal of the American Chemical Society. 144(32)
Fluorescence imaging is a powerful method for probing macromolecular dynamics in biological systems, however approaches for cellular RNA imaging are limited to the investigation of individual RNA constructs or bulk RNA labeling methods compatible pri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab50f0fb0f96f17bd4678a6b4ff700b0
https://pubmed.ncbi.nlm.nih.gov/35930766
https://pubmed.ncbi.nlm.nih.gov/35930766
Publikováno v:
Biochemistry. 58:3386-3395
Epitranscriptomic RNA modifications can serve as recognition elements for the recruitment of effector proteins (i.e., "readers") to modified transcripts. While these interactions play an important role in mRNA regulation, there is a major gap in our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19cf833a4c5f7c0a73429e4ee33a4c4b
https://doi.org/10.1021/acs.biochem.9b00485
https://doi.org/10.1021/acs.biochem.9b00485
Autor:
Yu Zhang, Moira L. Flanagan, Jesse N. Krejci, Yueyu Yao, Shimu Liu, David J. Gorin, A. Emilia Arguello, Jiyeon Kim, Drew E. Colman
Publikováno v:
Chemical Science. 9:2105-2112
The challenge of site-selectivity must be overcome in many chemical research contexts, including selective functionalization in complex natural products and labeling of one biomolecule in a living system. Synthetic catalysts incorporating molecular r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21bb39245e774a45d11296237159007f
https://doi.org/10.1039/c7sc04554a
https://doi.org/10.1039/c7sc04554a
Publikováno v:
Journal of the American Chemical Society. 139:17249-17252
Epitranscriptomic RNA modifications can regulate mRNA function; however, there is a major gap in our understanding of the biochemical mechanisms mediating their effects. Here, we develop a chemical proteomics approach relying upon photo-cross-linking
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75f55b930dd9e65363f1b0f1c9b1d158
https://doi.org/10.1021/jacs.7b09213
https://doi.org/10.1021/jacs.7b09213
Publikováno v:
Current protocols in nucleic acid chemistry. 75(1)
Post-transcriptional modifications play an important role in RNA biology. In particular, the addition of small chemical groups to the nucleobases of mRNA can affect how modified transcripts are processed in the cell, thereby impacting gene expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eededb20c9cf7e26b86f6a42f9998fa7
https://pubmed.ncbi.nlm.nih.gov/30408339
https://pubmed.ncbi.nlm.nih.gov/30408339
Publikováno v:
Journal of the American Chemical Society. 139(48)
Epitranscriptomic RNA modifications can regulate mRNA function; however, there is a major gap in our understanding of the biochemical mechanisms mediating their effects. Here, we develop a chemical proteomics approach relying upon photo-cross-linking
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3d660043e58d4d878a6e557e79e1ee80
https://pubmed.ncbi.nlm.nih.gov/29140688
https://pubmed.ncbi.nlm.nih.gov/29140688