Výsledky vyhledávání - "Emilia A Kimura"

Akademický článek

Effect of fosmidomycin on metabolic and transcript profiles of the methylerythritol phosphate pathway in Plasmodium falciparum

Autor: María B Cassera, Emilio F Merino, Valnice J Peres, Emilia A Kimura, Gerhard Wunderlich, Alejandro M Katzin

Publikováno v: Memorias do Instituto Oswaldo Cruz, Vol 102, Iss 3, Pp 377-384 (2007)

In Plasmodium falciparum, the formation of isopentenyl diphosphate and dimethylallyl diphosphate, central intermediates in the biosynthesis of isoprenoids, occurs via the methylerythritol phosphate (MEP) pathway. Fosmidomycin is a specific inhibitor

Externí odkaz: https://doaj.org/article/b7f069bcfde046a0946a99f0f209621b

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Akademický článek

Presence of Phylloquinone in the Intraerythrocytic Stages of Plasmodium falciparum

Autor: Rodrigo A. C. Sussmann, Heloisa B. Gabriel, Alejandro García Ríos, Danielle S. Menchaca Vega, Lydia F. Yamaguchi, Antonio Doménech-Carbó, Gerardo Cebrián-Torrejón, Emilia A. Kimura, Massuo J. Kato, Ignasi Bofill Verdaguer, Marcell Crispim, Alejandro M. Katzin

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)

Malaria is one of the most widespread parasitic diseases, especially in Africa, Southeast Asia and South America. One of the greatest problems for control of the disease is the emergence of drug resistance, which leads to a need for the development o

Externí odkaz: https://doaj.org/article/a2a0c61706c245b08503bdbba258f959

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Akademický článek

Tocopherol biosynthesis in Leishmania (L.) amazonensis promastigotes

Autor: José Mário F. Balanco, Rodrigo A.C. Sussmann, Ignasi B. Verdaguer, Heloisa B. Gabriel, Emilia A. Kimura, Alejandro M. Katzin

Publikováno v: FEBS Open Bio, Vol 9, Iss 4, Pp 743-754 (2019)

Leishmaniasis is a neglected disease caused by a trypanosomatid protozoan of the genus Leishmania. Most drugs used to treat leishmaniasis are highly toxic, and the emergence of drug‐resistant strains has been observed. Therefore, new therapeutic ta

Externí odkaz: https://doaj.org/article/bfe0ccad99dc4d97b870c7ac949f815d

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Akademický článek

Plasmodium falciparum uses vitamin E to avoid oxidative stress

Autor: Rodrigo A. C. Sussmann, Wesley L. Fotoran, Emilia A. Kimura, Alejandro M. Katzin

Publikováno v: Parasites & Vectors, Vol 10, Iss 1, Pp 1-8 (2017)

Abstract Background Plasmodium falciparum is sensitive to oxidative stress in vitro and in vivo, and many drugs such as artemisinin, chloroquine and cercosporin interfere in the parasite’s redox system. To minimize the damage caused by reactive rad

Externí odkaz: https://doaj.org/article/5dd8a8e69c4f4abb8e8242e0191eaa53

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Tocopherol biosynthesis in Leishmania (L.) amazonensis promastigotes

Autor: Rodrigo A.C. Sussmann, Heloisa B. Gabriel, J M F Balanco, Ignasi Bofill Verdaguer, Emilia A. Kimura, Alejandro M. Katzin

Publikováno v: FEBS Open Bio

Leishmaniasis is a neglected disease caused by a trypanosomatid protozoan of the genus Leishmania. Most drugs used to treat leishmaniasis are highly toxic, and the emergence of drug-resistant strains has been observed. Therefore, new therapeutic targ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48eeff7de698bfb0d03dfb6a422f8afe
http://europepmc.org/articles/PMC6443866

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Exploring Ubiquinone Biosynthesis Inhibition as a Strategy for Improving Atovaquone Efficacy in Malaria

Autor: Rodrigo A.C. Sussmann, Fernando G. de Almeida, Mauro F Azevedo, Emilia A. Kimura, H R Melo, Marcell Crispim, C A Zafra, Ignasi Bofill Verdaguer, Alejandro M. Katzin, N L Buriticá

Publikováno v: Antimicrob Agents Chemother

Atovaquone (AV) acts on the malaria parasite by competing with ubiquinol (UQH(2)) for its union to the mitochondrial bc(1) complex, preventing the ubiquinone-8 and ubiquinone-9 (UQ-8 and UQ-9) redox recycling, which is a necessary step in pyrimidine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be3ad2bf42c03fd69cd8aa66e00d376
https://doi.org/10.1128/aac.01516-20

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Prenylquinones in human parasitic protozoa: biosynthesis, physiological functions, and potential as chemotherapeutic targets

Autor: Camila A Zafra, Marcell Crispim, Alejandro M. Katzin, Rodrigo A.C. Sussmann, Ignasi Bofill Verdaguer, Emilia A. Kimura

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Molecules, Vol 24, Iss 20, p 3721 (2019)
Molecules

Human parasitic protozoa cause a large number of diseases worldwide and, for some of these diseases, there are no effective treatments to date, and drug resistance has been observed. For these reasons, the discovery of new etiological treatments is n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01f34ba718a42c5862c196c8ad12cf3f

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Antimalarial activity of the terpene nerolidol

Autor: Alexandre Y. Saito, Emilia A. Kimura, Rodrigo A.C. Sussmann, Danielle S. Menchaca Vega, Adriana A. Marin Rodriguez, Alejandro M. Katzin

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Malaria, an infectious disease that kills more than 438,000 people per year worldwide, is a major public health problem. The emergence of strains resistant to conventional therapeutic agents necessitates the discovery of new drugs. We previously demo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95b26295474cf805dcebca132b70a2bb
https://doi.org/10.1016/j.ijantimicag.2016.08.017

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Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate

Autor: Alejandro M. Katzin, Mauro F Azevedo, Emilia A. Kimura, Heloisa B. Gabriel

Publikováno v: Memórias do Instituto Oswaldo Cruz
Memórias do Instituto Oswaldo Cruz., Vol 113, Iss 10 (2018)
Memórias do Instituto Oswaldo Cruz, Volume: 113, Issue: 10, Article number: e180174, Published: 13 AUG 2018

Farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase (FPPS/GGPPS) is a key enzyme in the synthesis of isoprenic chains. Risedronate, a bisphosphonate containing nitrogen (N-BP), is a potent inhibitor of blood stage Plasmodium. Here, we s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e785027fe6cba0746106c4e8277630e
https://doi.org/10.1590/0074-02760180174

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Plasmodium falciparum uses vitamin E to avoid oxidative stress

Autor: Alejandro M. Katzin, Rodrigo A.C. Sussmann, Wesley Luzetti Fotoran, Emilia A. Kimura

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Parasites & Vectors
Parasites & Vectors, Vol 10, Iss 1, Pp 1-8 (2017)

Background Plasmodium falciparum is sensitive to oxidative stress in vitro and in vivo, and many drugs such as artemisinin, chloroquine and cercosporin interfere in the parasite’s redox system. To minimize the damage caused by reactive radicals, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d0a9c22967cea00f2f277379c8d9b3e
https://doi.org/10.1186/s13071-017-2402-3

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