Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Emilia, Turco"'
Autor:
Matteo Sorge, Giulia Savoré, Andrea Gallo, Davide Acquarone, Mauro Sbroggiò, Silvia Velasco, Federica Zamporlini, Saveria Femminò, Enrico Moiso, Giampaolo Morciano, Elisa Balmas, Andrea Raimondi, Gabrielle Nattenberg, Rachele Stefania, Carlo Tacchetti, Angela Maria Rizzo, Paola Corsetto, Alessandra Ghigo, Emilia Turco, Fiorella Altruda, Lorenzo Silengo, Paolo Pinton, Nadia Raffaelli, Nathan J Sniadecki, Claudia Penna, Pasquale Pagliaro, Emilio Hirsch, Chiara Riganti, Guido Tarone, Alessandro Bertero, Mara Brancaccio
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 10, Pp 2450-2484 (2024)
Abstract Defining the molecular mechanisms underlying cardiac resilience is crucial to find effective approaches to protect the heart. A physiologic level of ROS is produced in the heart by fatty acid oxidation, but stressful events can boost ROS and
Externí odkaz:
https://doaj.org/article/fbbe12027f6940b5871e50bcfc957a2f
Cancer cell stiffening via CoQ10 and UBIAD1 regulates ECM signaling and ferroptosis in breast cancer
Autor:
Giovanni Tosi, Alessandro Paoli, Gaia Zuccolotto, Emilia Turco, Manuela Simonato, Daniela Tosoni, Francesco Tucci, Pietro Lugato, Monica Giomo, Nicola Elvassore, Antonio Rosato, Paola Cogo, Salvatore Pece, Massimo M. Santoro
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-24 (2024)
Abstract CoQ10 (Coenzyme Q10) is an essential fat-soluble metabolite that plays a key role in cellular metabolism. A less-known function of CoQ10 is whether it may act as a plasma membrane-stabilizing agent and whether this property can affect cancer
Externí odkaz:
https://doaj.org/article/fcdadd32e3c74c049a3cabd84a68dbf7
Autor:
Giorgia Centonze, Dora Natalini, Silvia Grasso, Alessandro Morellato, Vincenzo Salemme, Alessio Piccolantonio, Giacomo D’Attanasio, Aurora Savino, Olga Teresa Bianciotto, Matteo Fragomeni, Andrea Scavuzzo, Matteo Poncina, Francesca Nigrelli, Mario De Gregorio, Valeria Poli, Pietro Arina, Daniela Taverna, Joanna Kopecka, Sirio Dupont, Emilia Turco, Chiara Riganti, Paola Defilippi
Publikováno v:
Cell Death and Disease, Vol 14, Iss 12, Pp 1-16 (2023)
Abstract p140Cap is an adaptor protein involved in assembling multi-protein complexes regulating several cellular processes. p140Cap acts as a tumor suppressor in breast cancer (BC) and neuroblastoma patients, where its expression correlates with a b
Externí odkaz:
https://doaj.org/article/9b85e2507048469f836b2d800e0a4611
Autor:
Vincenzo Salemme, Mauro Vedelago, Alessandro Sarcinella, Federico Moietta, Alessio Piccolantonio, Enrico Moiso, Giorgia Centonze, Marta Manco, Andrea Guala, Alessia Lamolinara, Costanza Angelini, Alessandro Morellato, Dora Natalini, Raffaele Calogero, Danny Incarnato, Salvatore Oliviero, Laura Conti, Manuela Iezzi, Daniela Tosoni, Giovanni Bertalot, Stefano Freddi, Francesco A. Tucci, Francesco De Sanctis, Cristina Frusteri, Stefano Ugel, Vincenzo Bronte, Federica Cavallo, Paolo Provero, Marta Gai, Daniela Taverna, Emilia Turco, Salvatore Pece, Paola Defilippi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract The p140Cap adaptor protein is a tumor suppressor in breast cancer associated with a favorable prognosis. Here we highlight a function of p140Cap in orchestrating local and systemic tumor-extrinsic events that eventually result in inhibition
Externí odkaz:
https://doaj.org/article/6ef08fc8d1c74047923f8519dfa3b883
Autor:
Vincenzo Salemme, Giorgia Centonze, Lidia Avalle, Dora Natalini, Alessio Piccolantonio, Pietro Arina, Alessandro Morellato, Ugo Ala, Daniela Taverna, Emilia Turco, Paola Defilippi
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Breast cancer is a highly heterogeneous disease, at both inter- and intra-tumor levels, and this heterogeneity is a crucial determinant of malignant progression and response to treatments. In addition to genetic diversity and plasticity of cancer cel
Externí odkaz:
https://doaj.org/article/cb9e2bab7a854b828696358e90291ed1
Autor:
Kevin Peikert, Enrica Federti, Alessandro Matte, Gabriela Constantin, Enrica Caterina Pietronigro, Paolo Francesco Fabene, Paola Defilippi, Emilia Turco, Federico Del Gallo, Pietro Pucci, Angela Amoresano, Anna Illiano, Flora Cozzolino, Maria Monti, Francesca Garello, Enzo Terreno, Seth Leo Alper, Hannes Glaß, Lisann Pelzl, Katja Akgün, Tjalf Ziemssen, Rainer Ordemann, Florian Lang, Anna Maria Brunati, Elena Tibaldi, Immacolata Andolfo, Achille Iolascon, Giuseppe Bertini, Mario Buffelli, Carlo Zancanaro, Erika Lorenzetto, Angela Siciliano, Massimiliano Bonifacio, Adrian Danek, Ruth Helen Walker, Andreas Hermann, Lucia De Franceschi
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-15 (2021)
Abstract Chorea-Acanthocytosis (ChAc) is a devastating, little understood, and currently untreatable neurodegenerative disease caused by VPS13A mutations. Based on our recent demonstration that accumulation of activated Lyn tyrosine kinase is a key p
Externí odkaz:
https://doaj.org/article/41fdfcd9d3254dc9b0d9bd47117287f7
Autor:
Chiara Enrico Bena, Marco Del Giudice, Alice Grob, Thomas Gueudré, Mattia Miotto, Dimitra Gialama, Matteo Osella, Emilia Turco, Francesca Ceroni, Andrea De Martino, Carla Bosia
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Individual cells exhibit specific proliferative responses to changes in microenvironmental conditions. Whether such potential is constrained by the cell density throughout the growth process is however unclear. Here, we identify a theoretica
Externí odkaz:
https://doaj.org/article/2cad83971b2c45e29d0e3d3554b47278
Autor:
Maurizio Vitadello, Matteo Sorge, Elena Percivalle, Elena Germinario, Daniela Danieli‐Betto, Emilia Turco, Guido Tarone, Mara Brancaccio, Luisa Gorza
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 11, Iss 3, Pp 802-819 (2020)
Abstract Background Unloading/disuse induces skeletal muscle atrophy in bedridden patients and aged people, who cannot prevent it by means of exercise. Because interventions against known atrophy initiators, such as oxidative stress and neuronal NO s
Externí odkaz:
https://doaj.org/article/bf8f71caaed14f839a54e7ae851363d0
Autor:
Mattia Camera, Isabella Russo, Valentina Zamboni, Alessandra Ammoni, Simona Rando, Alessandro Morellato, Irene Cimino, Costanza Angelini, Paolo Giacobini, Roberto Oleari, Federica Amoruso, Anna Cariboni, Isabelle Franceschini, Emilia Turco, Paola Defilippi, Giorgio R. Merlo
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
p140Cap, encoded by the gene SRCIN1 (SRC kinase signaling inhibitor 1), is an adaptor/scaffold protein highly expressed in the mouse brain, participating in several pre- and post-synaptic mechanisms. p140Cap knock-out (KO) female mice show severe hyp
Externí odkaz:
https://doaj.org/article/1e1414a0b8e54c0aabd09a040c94d35a
Autor:
Tânia D. F. Costa, Ting Zhuang, Julie Lorent, Emilia Turco, Helene Olofsson, Miriam Masia-Balague, Miao Zhao, Parisa Rabieifar, Neil Robertson, Raoul Kuiper, Jonas Sjölund, Matthias Spiess, Pablo Hernández-Varas, Uta Rabenhorst, Pernilla Roswall, Ran Ma, Xiaowei Gong, Johan Hartman, Kristian Pietras, Peter D. Adams, Paola Defilippi, Staffan Strömblad
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Oncogene induced senescence protects cells from unrestricted growth and cancer. Here, the authors show that PAK4 overrides this senescence in breast cancer cells through phosphorylation of RELB, thereby inhibiting transcription of the senescence regu
Externí odkaz:
https://doaj.org/article/b1b8d976c5c54a27ab395cced065f0c0