Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Emile R Chimusa"'
Autor:
Daneil Feldmann, Christian D Bope, Jon Patricios, Emile R Chimusa, Malcolm Collins, Alison V September
Publikováno v:
PLoS ONE, Vol 17, Iss 10, p e0274354 (2022)
Predisposition to anterior cruciate ligament (ACL) rupture is multi-factorial, with variation in the genome considered a key intrinsic risk factor. Most implicated loci have been identified from candidate gene-based approach using case-control associ
Externí odkaz:
https://doaj.org/article/6438dade8be84c97ac00cb92555e6821
Autor:
Delesa Damena, Samuel Tolosa, Milkessa Hailemariam, Aboma Zewude, Adane Worku, Biruk Mekonnen, Temesgen Mohammed, Addisu Admasu, Emile R Chimusa, Adane Mihret, Tamrat Abebe, Gobena Ameni
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0218545 (2019)
BackgroundTuberculosis (TB) is one of the major public health problems in Ethiopia. Data on genetic diversity and resistance profile of circulating TB strains is critical for informing the national TB control program.MethodsA cross-sectional study wa
Externí odkaz:
https://doaj.org/article/dc0c888880bc4180924e814d11bda58d
Autor:
Siana Nkya, Collin Nzunda, Emmanuel Saukiwa, Frida Kaywanga, Eliud Buberwa, David Solomon, Heavenlight Christopher, Doreen Ngowi, Julieth Johansen, Florence Urio, Josephine Mgaya, Salman Karim, Mohamed Zahir Alimohamed, Raphael Z. Sangeda, Clara Chamba, Emile R. Chimusa, Enrico Novelli, Julie Makani
Publikováno v:
BMC Medical Genomics, Vol 17, Iss 1, Pp 1-8 (2024)
Abstract Background Pharmacogenomics of hydroxyurea is an important aspect in the management of sickle cell disease (SCD), especially in the era of genomic medicine. Genetic variations in loci associated with HbF induction and drug metabolism are pri
Externí odkaz:
https://doaj.org/article/d92c2a41448b440ea28e8f78c68c0d77
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 11, p e1004512 (2015)
A shortage of practical skills and relevant expertise is possibly the primary obstacle to social upliftment and sustainable development in Africa. The "omics" fields, especially genomics, are increasingly dependent on the effective interpretation of
Externí odkaz:
https://doaj.org/article/040327137528460aa18c4aa66344ba55
Autor:
Emile R Chimusa, Ayton Meintjies, Milaine Tchanga, Nicola Mulder, Cathal Seoighe, Himla Soodyall, Rajkumar Ramesar
Publikováno v:
PLoS Genetics, Vol 11, Iss 3, p e1005052 (2015)
We report a study of genome-wide, dense SNP (∼ 900K) and copy number polymorphism data of indigenous southern Africans. We demonstrate the genetic contribution to southern and eastern African populations, which involved admixture between indigenous
Externí odkaz:
https://doaj.org/article/cc4446b28634418c857fcc85ff1b6e7c
Autor:
Francis E. Agamah, Thomas H. A. Ederveen, Michelle Skelton, Darren P. Martin, Emile R. Chimusa, Peter A. C. ’t Hoen
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
BackgroundCOVID-19 disease is characterized by a spectrum of disease phases (mild, moderate, and severe). Each disease phase is marked by changes in omics profiles with corresponding changes in the expression of features (biosignatures). However, int
Externí odkaz:
https://doaj.org/article/da6917fc083f4b01b143c354996d6281
Autor:
Michelle Daya, Lize van der Merwe, Ushma Galal, Marlo Möller, Muneeb Salie, Emile R Chimusa, Joshua M Galanter, Paul D van Helden, Brenna M Henn, Chris R Gignoux, Eileen Hoal
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82224 (2013)
Admixture is a well known confounder in genetic association studies. If genome-wide data is not available, as would be the case for candidate gene studies, ancestry informative markers (AIMs) are required in order to adjust for admixture. The predomi
Externí odkaz:
https://doaj.org/article/f67a454426964a82b186f80ce36b0e1e
Autor:
Emile R Chimusa, Michelle Daya, Marlo Möller, Raj Ramesar, Brenna M Henn, Paul D van Helden, Nicola J Mulder, Eileen G Hoal
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73971 (2013)
Admixed populations can make an important contribution to the discovery of disease susceptibility genes if the parental populations exhibit substantial variation in susceptibility. Admixture mapping has been used successfully, but is not designed to
Externí odkaz:
https://doaj.org/article/151d690633a348dd9b3bed133a6f68ec
Autor:
Prisca K. Thami, Wonderful T. Choga, Collet Dandara, Stephen J. O’Brien, Myron Essex, Simani Gaseitsiwe, Emile R. Chimusa
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
HIV infection continues to be a major global public health issue. The population heterogeneity in susceptibility or resistance to HIV-1 and progression upon infection is attributable to, among other factors, host genetic variation. Therefore, identif
Externí odkaz:
https://doaj.org/article/81eba73213784e279e6a6832680e1247
Autor:
Jonathan N. Katsukunya, Nyarai D. Soko, Jashira Naidoo, Brian Rayner, Dirk Blom, Phumla Sinxadi, Emile R. Chimusa, Michelle Dandara, Kevin Dzobo, Erika Jones, Collet Dandara
Publikováno v:
International Journal of Hypertension, Vol 2023 (2023)
In Africa, the burden of hypertension has been rising at an alarming rate for the last two decades and is a major cause for cardiovascular disease (CVD) mortality and morbidity. Hypertension is characterised by elevated blood pressure (BP) ≥ 140/90
Externí odkaz:
https://doaj.org/article/013083cf4127412a82b975bde3918c17