Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Emile J. Laurensse"'
Autor:
Theo W. Prins, Ingrid M.J. Scholtens, Arno W. Bak, Jeroen P. van Dijk, Marleen M. Voorhuijzen, Emile J. Laurensse, Esther J. Kok
Publikováno v:
Data in Brief, Vol 9, Iss C, Pp 43-46 (2016)
This article contains data related to the research article entitled “A case study to determine the geographical origin of unknown GM papaya in routine food sample analysis, followed by identification of papaya events 16-0-1 and 18-2-4” (Prins et
Externí odkaz:
https://doaj.org/article/d4bc9b1a9323468297be06b15684e521
Publikováno v:
European Journal of Cancer and Clinical Oncology. 27:263-267
Inhibition of thymidylate synthase (TS) by the 5-fluorouracil (5-FU) metabolite FdUMP is considered to be the main mechanism of action of 5-FU. TS from colorectal tumours and normal colon mucosa from 10 untreated patients was studied. There was a lar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0003b126d4e78d9706b623176d1136ea
https://doi.org/10.1016/0277-5379(91)90512-c
https://doi.org/10.1016/0277-5379(91)90512-c
Publikováno v:
Cancer, 68, 1903-1909. John Wiley and Sons Inc.
Peters, G J, van Groeningen, C J, Laurensse, E & Pinedo, H M 1991, ' A comparison of 5-fluorouracil metabolism in human colorectal cancer and colon mucosa ', Cancer, vol. 68, pp. 1903-1909 .
Peters, G J, van Groeningen, C J, Laurensse, E & Pinedo, H M 1991, ' A comparison of 5-fluorouracil metabolism in human colorectal cancer and colon mucosa ', Cancer, vol. 68, pp. 1903-1909 .
The metabolism of 5-fluorouracil (5-FU) was studied in biopsy specimens of primary colorectal cancer and healthy colonic mucosa obtained from previously untreated patients immediately after surgical removal. The conversion of 5-FU to anabolites was m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d551aa1425e84aa698d7dfeee1eb560
https://research.vumc.nl/en/publications/5c954e6d-3ef9-4f4a-99a0-b3c531538404
https://research.vumc.nl/en/publications/5c954e6d-3ef9-4f4a-99a0-b3c531538404
Publikováno v:
Clinica Chimica Acta. 158:193-198
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a67c0698607bf2ab70dd69d23ef065a
https://doi.org/10.1016/0009-8981(86)90236-6
https://doi.org/10.1016/0009-8981(86)90236-6
Publikováno v:
Clinica chimica acta; international journal of clinical chemistry. 178(1)
A new sensitive assay for pyrimidine nucleoside phosphorylase using non-radioactive substrates is described. With the natural substrate undine (UR) and the analog, 5′-deoxy-5-fluorouridine (5′dFUR) conditions have been optimized to measure the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2815c8c281f0e2def42984fe941d8e4
https://pubmed.ncbi.nlm.nih.gov/2976326
https://pubmed.ncbi.nlm.nih.gov/2976326
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781468456752
Thymidylate synthase (TS) is a key enzyme in de novo synthesis of TMP (Fig. 1). TS catalyzes the conversion of dUMP to TMP for which 5, 10-methylenetetrahydrofolate (CH2THF) acts as the methyl-donor; the Km for dUMP is about 1–5 μM (1–5). Inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49c38175013edcd6ef704fc96387a4aa
https://doi.org/10.1007/978-1-4684-5673-8_72
https://doi.org/10.1007/978-1-4684-5673-8_72
Publikováno v:
European journal of cancerclinical oncology. 23(12)
Purine nucleosides and ribose- 5 -phosphate (Rib- 5 -P) were used to modulate the metabolism and cytotoxicity of 5 -fluorouracil ( 5 -FU) in order to get better understanding of the mechanism of action of 5 -FU. In extracts from five different cell l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::433b848f4974bb8eae4766801aa38359
https://pubmed.ncbi.nlm.nih.gov/3436351
https://pubmed.ncbi.nlm.nih.gov/3436351
Publikováno v:
Pediatric Research. 24:130-130
DUP-785 (Brequinar sodium) is a novel potent inhibitor of the pyrimidine de novo enzyme dihydroorotic acid dehydrogenase (DHO-DH). We studied the relationship between DHO-DH activity and in vitro growth-inhibitory effects and in vivo antitumor effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7c53cabf48c03abb75429323ab2d7da
https://doi.org/10.1203/00006450-198807000-00137
https://doi.org/10.1203/00006450-198807000-00137
Publikováno v:
Pediatric Research. 24:130-130
114 FLUOROPYRIMIDINE METABOLISM IN HUMAN HEAD AND NECK CANCER XENOGRAFTS AND MURINE COLON TUMORS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4902e7a5e3d40690cf74f6efa0f53c5e
https://doi.org/10.1203/00006450-198807000-00138
https://doi.org/10.1203/00006450-198807000-00138
Autor:
Godefridus J Peters, Emile J Laurensse, Cees J Van Groeningen, Sybren Meijer, Herbert M Pinedo
Publikováno v:
Pediatric Research. 24:130-130
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90248e1755119fd6a505ac0a53564f33
https://doi.org/10.1203/00006450-198807000-00139
https://doi.org/10.1203/00006450-198807000-00139