Zobrazeno 1 - 10 of 160 pro vyhledávání: '"Emile, de Heer"'
1
Akademický článek
Analysis of the genomic architecture of a complex trait locus in hypertensive rat models links Tmem63c to kidney damage
Autor: Angela Schulz, Nicola Victoria Müller, Nina Anne van de Lest, Andreas Eisenreich, Martina Schmidbauer, Andrei Barysenka, Bettina Purfürst, Anje Sporbert, Theodor Lorenzen, Alexander M Meyer, Laura Herlan, Anika Witten, Frank Rühle, Weibin Zhou, Emile de Heer, Marion Scharpfenecker, Daniela Panáková, Monika Stoll, Reinhold Kreutz
Publikováno v: eLife, Vol 8 (2019)
Unraveling the genetic susceptibility of complex diseases such as chronic kidney disease remains challenging. Here, we used inbred rat models of kidney damage associated with elevated blood pressure for the comprehensive analysis of a major albuminur
Externí odkaz: https://doaj.org/article/3ce65e8761e146108e0f630955c54002
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3
Akademický článek
Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling
Autor: Alessia Calcagnì, Lotte kors, Eric Verschuren, Rossella De Cegli, Nicolina Zampelli, Edoardo Nusco, Stefano Confalonieri, Giovanni Bertalot, Salvatore Pece, Carmine Settembre, Gabriel G Malouf, Jaklien C Leemans, Emile de Heer, Marco Salvatore, Dorien JM Peters, Pier Paolo Di Fiore, Andrea Ballabio
Publikováno v: eLife, Vol 5 (2016)
TFE-fusion renal cell carcinomas (TFE-fusion RCCs) are caused by chromosomal translocations that lead to overexpression of the TFEB and TFE3 genes (Kauffman et al., 2014). The mechanisms leading to kidney tumor development remain uncharacterized and
Externí odkaz: https://doaj.org/article/32edca15298541028482d193be8401b5
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4
Akademický článek
Pregnancy close to the edge: an immunosuppressive infiltrate in the chorionic plate of placentas from uncomplicated egg cell donation.
Autor: Dorrith Schonkeren, Godelieve Swings, Drucilla Roberts, Frans Claas, Emile de Heer, Sicco Scherjon
Publikováno v: PLoS ONE, Vol 7, Iss 3, p e32347 (2012)
In pregnancies achieved after egg donation (ED) tolerance towards a completely allogeneic fetus is mediated by several complex immunoregulatory mechanisms, of which numerous aspects are still unknown. A distinct lesion not described previously in the
Externí odkaz: https://doaj.org/article/e793c318b9094052a7d1d35936020ce6
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5
Disparate phospho-Smad2 levels in advanced type 2 diabetes patients with diabetic nephropathy and early experimental db/db mouse model
Autor: Amaya García de Vinuesa, Lise Høj Thomsen, Jenny Norlin, Lisbeth Nielsen Fink, Peter ten Dijke, Troels Krarup Hansen, Emile de Heer, Morten Fog-Tonnesen, Alexander Rosendahl
Publikováno v: Renal Failure
Thomsen, L H, Fog-Tonnesen, M, Nielsen Fink, L, Norlin, J, García de Vinuesa, A, Hansen, T K, de Heer, E, Ten Dijke, P & Rosendahl, A 2017, ' Disparate phospho-Smad2 levels in advanced type 2 diabetes patients with diabetic nephropathy and early experimental db/db mouse model ', Renal Failure, vol. 39, no. 1, pp. 629-642 . https://doi.org/10.1080/0886022X.2017.1361837
Renal Failure, 39(1), 629-642
Uncontrolled activation of transforming growth factor beta (TGF-β) family members is hypothesized to participate in type 2 diabetes (T2D) dependent diabetic nephropathy (DN). We evaluated and compared downstream activation of the Smad2-signaling pat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::892395ca2e35ab44ee6ea598e339a1ce
http://europepmc.org/articles/PMC6446227
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6
Apolipoprotein C-I plays a role in the pathogenesis of glomerulosclerosis
Autor: Leendert A. van Es, Jimmy F.P. Berbée, Pascal Bus, Hans J. Baelde, Emile de Heer, Ron Wolterbeek, Jan A. Bruijn, Patrick C.N. Rensen, Rosalie Bor, Louis M. Havekes, Louise Pierneef
Publikováno v: The Journal of Pathology. 241:589-599
Diabetic nephropathy is the leading cause of end-stage renal disease. Diabetic patients have increased plasma concentrations of apolipoprotein C-I (apoCI), and meta-analyses found that a polymorphism in APOC1 is associated with an increased risk of d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ff770b95d4a794ec0db6fb3784117873
https://doi.org/10.1002/path.4859
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7
Smad2 Phosphorylation in Diabetic Kidney Tubule Epithelial Cells Is Associated with Modulation of Several Transforming Growth Factor-β Family Members
Autor: Troels Krarup Hansen, Emile de Heer, Lisbeth Nielsen Fink, Amaya García de Vinuesa, Jenny Norlin, Morten Fog-Tonnesen, Alexander Rosendahl, Peter ten Dijke, Lise Høj Thomsen
Publikováno v: Nephron
Nephron, 135(4), 291-306
Thomsen, L H, Fog-Tonnesen, M, Fink, L N, Norlin, J, de Vinuesa, A G, Hansen, T K, de Heer, E, ten Dijke, P & Rosendahl, A 2017, ' Smad2 Phosphorylation in Diabetic Kidney Tubule Epithelial Cells Is Associated with Modulation of Several Transforming Growth Factor-beta Family Members ', Nephron Clinical Practice, vol. 135, no. 4, pp. 291-306 . https://doi.org/10.1159/000453337
Background: The role of transforming growth factor-β (TGF-β) has recently gained much attention in diabetic nephropathy and kidney fibrosis. In this study, we extend this to an assessment of transcriptional regulation of the entire TGF-β superfami
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40781bfa5dab586ec9b83c9b89cb8f0c
https://doi.org/10.1159/000453337
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9
Dose-Titrated Vasopressin V2 Receptor Antagonist Improves Renoprotection in a Mouse Model for Autosomal Dominant Polycystic Kidney Disease
Autor: Debbie Zittema, Esther Meijer, Harry van Goor, Dorien J.M. Peters, Ron T. Gansevoort, Emile de Heer, Irina B. Versteeg, Kimberley A. M. Veraar
Publikováno v: American Journal of Nephrology, 44(3), 194-203
American Journal of Nephrology, 44(3), 194-203. KARGER
Background: In autosomal dominant polycystic kidney disease, renoprotective treatment with a vasopressin V2 receptor antagonist (V2RA) is given in a fixed dose (FD). Disease progression and drug habituation could diminish treatment efficacy. We inves
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b398687c87105d2a22434545e305e25b
https://research.rug.nl/en/publications/4581a6dd-4ccf-4351-9c62-45a4394ae470
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10
Inhibition of Activin Signaling Slows Progression of Polycystic Kidney Disease
Autor: Fatiha el Bouazzaoui, Emile de Heer, Olli Ritvos, Dorien J.M. Peters, Kimberley Veraar, Sebastian B.T. Jianu, Wouter N. Leonhard, Arja Pasternack, Martijn H. Breuning, Steven J. Kunnen, Peter ten Dijke, Willem M.H. Hoogaars, Anna J. Plugge
Publikováno v: Journal of the American Society of Nephrology, 27(12), 3589-3599
Journal of the American Society of Nephrology, 27(12), 3589-3599. American Society of Nephrology
Journal of the American Society of Nephrology
Leonhard, W M, Kunnen, S J, Plugge, A J, Pasternack, A, Jianu, B, Veraar, K, El Bouazzaoui, F, Hoogaars, W, ten Dijke, P, Breuning, M H, de Heer, E, Ritvos, O & Peters, D J 2016, ' Inhibition of Activin Signaling Slows Progression of Polycystic Kidney Disease. ', Journal of the American Society of Nephrology, vol. 27, no. 12, pp. 3589-3599 . https://doi.org/10.1681/ASN.2015030287
Autosomal dominant polycystic kidney disease (ADPKD), characterized by the formation of numerous kidney cysts, is caused by PKD1 or PKD2 mutations and affects 0.1% of the population. Although recent clinical studies indicate that reduction of cAMP le
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93782ea39509f693d8ac7032c683b38c
https://research.vu.nl/en/publications/e444f41f-b3bc-433c-aa69-cc88d1c628e4
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