Výsledky vyhledávání - "Emil Oldenburg"

Site-specific nanobody-oligonucleotide conjugation for super-resolution imaging

Autor: Laura Teodori, Marjan Omer, Anders Märcher, Mads K. Skaanning, Veronica L. Andersen, Jesper S. Nielsen, Emil Oldenburg, Yuchen Lin, Kurt V. Gothelf, Jørgen Kjems

Publikováno v: Teodori, L, Omer, M, Märcher, A, Skaanning, M K, Andersen, V L, Nielsen, J S, Oldenburg, E, Lin, Y, Gothelf, K V & Kjems, J 2022, ' Site-specific nanobody-oligonucleotide conjugation for super-resolution imaging ', Journal of Biological Methods, vol. 9, no. 1, e159 . https://doi.org/10.14440/jbm.2022.381

Camelid single-domain antibody fragments, also called nanobodies, constitute a class of binders that are small in size (~15 kDa) and possess antigen-binding properties similar to their antibody counterparts. Facile production of recombinant nanobodie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2bcb05fe45598efc2ff79c147ed293c
https://doi.org/10.14440/jbm.2022.381

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Cleavage of peptidic inhibitors by target protease is caused by peptide conformational transition

Autor: Peng Xu, Emil Oldenburg, Peter A. Andreasen, Jan K. Jensen, Longguang Jiang, Tobias Kromann-Hansen, Mingdong Huang

Publikováno v: Jiang, L, Oldenburg, E, Kromann-Hansen, T, Xu, P, Jensen, J K, Andreasen, P A & Huang, M 2018, ' Cleavage of peptidic inhibitors by target protease is caused by peptide conformational transition ', Biochimica et Biophysica Acta-General Subjects, vol. 1862, no. 9, pp. 2017-2023 . https://doi.org/10.1016/j.bbagen.2018.06.016

Some peptide sequences can behave as either substrates or inhibitors of serine proteases. Working with a cyclic peptidic inhibitor of the serine protease urokinase-type plasminogen activator (uPA), we have now demonstrated a new mechanism for an inhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2116c4f0345700329fa5529d63b12037
https://doi.org/10.1016/j.bbagen.2018.06.016

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A Camelid-derived Antibody Fragment Targeting the Active Site of a Serine Protease Balances between Inhibitor and Substrate Behavior

Autor: Mingdong Huang, Peter A. Andreasen, Serge Muyldermans, Tobias Kromann-Hansen, Paul Declerck, Kristen Wing Yu Yung, Emil Oldenburg, Jacky Chi Ki Ngo, Gholamreza Hassanzadeh Ghassabeh

Publikováno v: Kromann-Hansen, T, Oldenburg, E, Yung, K W Y, Ghassabeh, G H, Muyldermans, S, Declerck, P J, Huang, M, Andreasen, P A & Ngo, J C K 2016, ' A Camelid-derived Antibody Fragment Targeting the Active Site of a Serine Protease Balances between Inhibitor and Substrate Behavior ', Journal of Biological Chemistry, vol. 291, pp. 15156-15168 . https://doi.org/10.1074/jbc.M116.732503

A peptide segment that binds the active site of a serine protease in a substrate-like manner may behave like an inhibitor or a substrate. However, there is sparse information on which factors determine the behavior a particular peptide segment will e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3acc25e9f8bb0da5e9a99671876b2651
https://doi.org/10.1074/jbc.m116.732503

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Abstract 4200: New potential therapeutic applications of WX-UK1, as a specific and potent inhibitor of human trypsin-like proteases

Autor: Terry F. Plasse, Christine R. Schar, Jan K. Jensen, Emil Oldenburg, Mark L. Levitt, Eric M. Towler, Eva Louise Lange, Reza Fathi, Danielle T. Abramson

Publikováno v: Cancer Research. 78:4200-4200

WX-UK1 (the active metabolite of upamostat) was originally developed as an inhibitor of the serine protease urokinase (uPA) with a Ki ~1 uM. To identify more sensitive targets, we performed a bioinformatic analysis of the ~200 human trypsin-like seri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5256e7552ed1508c737ab56577a42393
https://doi.org/10.1158/1538-7445.am2018-4200

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