Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Emil Mladenov"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Heavy-ion radiotherapy utilizing high linear energy transfer (high-LET) ionizing radiation (IR) is a promising cancer treatment modality owing to advantageous physical properties of energy deposition and associated toxicity over X-rays. Therapies uti
Externí odkaz:
https://doaj.org/article/424168a8df01409f80a104caebbd8e11
Autor:
Shan Xu, Ali Sak, Ben Niedermaier, Yasin Bahadir Erol, Michael Groneberg, Emil Mladenov, MingWei Kang, George Iliakis, Martin Stuschke
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
ARID1A is frequently mutated in colorectal cancer (CRC) cells. Loss of ARID1A function compromises DNA damage repair and increases the reliance of tumor cells on ATR-dependent DNA repair pathways. Here, we investigated the effect of ionizing radiatio
Externí odkaz:
https://doaj.org/article/2d014287579544f4995f66181e1c0d87
Autor:
Fanghua Li, Emil Mladenov, Yanjie Sun, Aashish Soni, Martin Stuschke, Beate Timmermann, George Iliakis
Publikováno v:
Cells, Vol 12, Iss 11, p 1530 (2023)
Alt-EJ is an error-prone DNA double-strand break (DSBs) repair pathway coming to the fore when first-line repair pathways, c-NHEJ and HR, are defective or fail. It is thought to benefit from DNA end-resection—a process whereby 3′ single-stranded
Externí odkaz:
https://doaj.org/article/d417227a457c454ba99e032b1b532712
Publikováno v:
Cells, Vol 12, Iss 10, p 1387 (2023)
We have recently reported that in G2-phase cells (but not S-phase cells) sustaining low loads of DNA double-strand break (DSBs), ATM and ATR regulate the G2-checkpoint epistatically, with ATR at the output-node, interfacing with the cell cycle throug
Externí odkaz:
https://doaj.org/article/d3f920a1217a469aafc42b8b5cab2c63
Autor:
Mithila Vaidya, Julian A. Jentsch, Susann Peters, Petra Keul, Sarah Weske, Markus H. Gräler, Emil Mladenov, George Iliakis, Gerd Heusch, Bodo Levkau
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 3, Pp 506-515 (2019)
Sphingolipid and cholesterol metabolism are closely associated at the structural, biochemical, and functional levels. Although HDL-associated sphingosine-1-phosphate (S1P) contributes to several HDL functions, and S1P signaling regulates glucose and
Externí odkaz:
https://doaj.org/article/1e10d14fa619480fb98e1d5f461cb15f
Autor:
Huaping Xiao, Fanghua Li, Emil Mladenov, Aashish Soni, Veronika Mladenova, Bing Pan, Rositsa Dueva, Martin Stuschke, Beate Timmermann, George Iliakis
Publikováno v:
Cells, Vol 11, Iss 13, p 2099 (2022)
The load of DNA double-strand breaks (DSBs) induced in the genome of higher eukaryotes by different doses of ionizing radiation (IR) is a key determinant of DSB repair pathway choice, with homologous recombination (HR) and ATR substantially gaining g
Externí odkaz:
https://doaj.org/article/177e341c6d6540558bf99266ef49665a
Publikováno v:
Molecules, Vol 27, Iss 5, p 1540 (2022)
Charged-particle radiotherapy (CPRT) utilizing low and high linear energy transfer (low-/high-LET) ionizing radiation (IR) is a promising cancer treatment modality having unique physical energy deposition properties. CPRT enables focused delivery of
Externí odkaz:
https://doaj.org/article/e68f8efbbbdb4fa28d888d7ba132c287
Publikováno v:
Cells, Vol 11, Iss 1, p 63 (2021)
The current view of the involvement of PI3-kinases in checkpoint responses after DNA damage is that ATM is the key regulator of G1-, S- or G2-phase checkpoints, that ATR is only partly involved in the regulation of S- and G2-phase checkpoints and tha
Externí odkaz:
https://doaj.org/article/8887d7050a764ab4b1a8173168b602b8
Publikováno v:
Life, Vol 11, Iss 6, p 560 (2021)
The utilization of high linear-energy-transfer (LET) ionizing radiation (IR) modalities is rapidly growing worldwide, causing excitement but also raising concerns, because our understanding of their biological effects is incomplete. Charged particles
Externí odkaz:
https://doaj.org/article/d1701c779b3b4e00a94f1e88a926d363
Autor:
Katja Paul, Minli Wang, Emil Mladenov, Alena Bencsik-Theilen, Theresa Bednar, Wenqi Wu, Hiroshi Arakawa, George Iliakis
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59505 (2013)
Biochemical and genetic studies suggest that vertebrates remove double-strand breaks (DSBs) from their genomes predominantly by two non-homologous end joining (NHEJ) pathways. While canonical NHEJ depends on the well characterized activities of DNA-d
Externí odkaz:
https://doaj.org/article/c983bad9608f4484bab78375f2afd1c4