Zobrazeno 1 - 10
of 292
pro vyhledávání: '"Emil Lou"'
Autor:
John Marshall, Sanjay Goel, Yan Yang, Emil Lou, Joanne Xiu, Hiroyuki Arai, Francesca Battaglin, Heinz-Josef Lenz, W Michael Korn, Jingyuan Wang, Shivani Soni, Wu Zhang, Joshua Millstein, Priya Jayachandran, Nishant Gandhi, Michael J Hall, Davendra Sohal, Sandra Algaze, Benjamin A Weinberg, Jae Ho Lo, Richard Goldberg, Aaron James Scott, Jimmy J Hwang
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 11 (2024)
Background In patients with colorectal cancer (CRC), the therapeutic effects of conventional immune checkpoint inhibitors targeting the adaptive immune system are largely limited to those with microsatellite instability-high tumors. Meanwhile, new im
Externí odkaz:
https://doaj.org/article/7994494135604d3480a8cd32c2292231
Autor:
Kai Zimmer, Florian Kocher, Gerold Untergasser, Brigitte Kircher, Arno Amann, Yasmine Baca, Joanne Xiu, W. Micheal Korn, Martin D. Berger, Heinz-Josef Lenz, Alberto Puccini, Elisa Fontana, Anthony F. Shields, John L. Marshall, Michael Hall, Wafik S. El-Deiry, David Hsiehchen, Teresa Macarulla, Josep Tabernero, Renate Pichler, Moh’d Khushman, Upender Manne, Emil Lou, Dominik Wolf, Viktorija Sokolova, Simon Schnaiter, Alain G. Zeimet, Pat Gulhati, Gerlig Widmann, Andreas Seeber
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-9 (2023)
Abstract Polybromo-1 (PBRM1) loss of function mutations are present in a fraction of biliary tract cancers (BTCs). PBRM1, a subunit of the PBAF chromatin-remodeling complex, is involved in DNA damage repair. Herein, we aimed to decipher the molecular
Externí odkaz:
https://doaj.org/article/5241117531c4407f8106f8137c687dda
Autor:
Fang-Shu Ou, Emil Lou, Joanne Xiu, Hiroyuki Arai, Francesca Battaglin, Heinz-Josef Lenz, Richard M Goldberg, Anthony F Shields, Yasmine Baca, Philip A Philip, John L Marshall, W Michael Korn, Andreas Seeber, Natsuko Kawanishi, Jingyuan Wang, Shivani Soni, Wu Zhang, Shannon M Mumenthaler, Joshua Millstein, Priya Jayachandran, Federico Innocenti, Annika Lenz, Sandra Algaze, Taline Khoukaz, Evanthia Roussos Torres, Jim P Abraham, Benjamin A Weinberg, Alan P Venook
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 1 (2024)
Background The C-C motif chemokine receptor 5 (CCR5)/C-C motif chemokine ligand 5 (CCL5) axis plays a major role in colorectal cancer (CRC). We aimed to characterize the molecular features associated with CCR5/CCL5 expression in CRC and to determine
Externí odkaz:
https://doaj.org/article/0070d43d733f41d1a13e1ef74847bb8d
Autor:
James L Gulley, Ari VanderWalde, Emil Lou, Nishant Gandhi, Heloisa Soares, Charalampos S Floudas, Dara Bracken-Clarke, Harris Krause, Alex Farrell, Minh Phan, Rusha Patel, Nyall London
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/93817049c3694a7eb9203957ba9574a3
Autor:
James L Gulley, Ari VanderWalde, Emil Lou, Nishant Gandhi, Heloisa Soares, Charalampos S Floudas, Dara Bracken-Clarke, Harris Krause, Minh Phan, Rusha Patel, Phillip Walker
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/0db02fc69fc34140afba0cc9ede084c4
Autor:
Akshat Sarkari, Sophie Korenfeld, Karina Deniz, Katherine Ladner, Phillip Wong, Sanyukta Padmanabhan, Rachel I Vogel, Laura A Sherer, Naomi Courtemanche, Clifford Steer, Kerem Wainer-Katsir, Emil Lou
Publikováno v:
eLife, Vol 12 (2023)
Disruption of intercellular communication within tumors is emerging as a novel potential strategy for cancer-directed therapy. Tumor-Treating Fields (TTFields) therapy is a treatment modality that has itself emerged over the past decade in active cli
Externí odkaz:
https://doaj.org/article/ee9c74b5c07d4d3cbf92f71ca8b2008d
Autor:
Laura Schubert, Andrew Elliott, Anh T. Le, Adriana Estrada-Bernal, Robert C. Doebele, Emil Lou, Hossein Borghaei, Michael J. Demeure, Razelle Kurzrock, Joshua E. Reuss, Sai-Hong Ignatius Ou, David R. Braxton, Christian A. Thomas, Sourat Darabi, Wolfgang Michael Korn, Wafik S. El-Deiry, Stephen V. Liu
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
PurposeGene fusions involving receptor tyrosine kinases (RTKs) define an important class of genomic alterations with many successful targeted therapies now approved for ALK, ROS1, RET and NTRK gene fusions. Fusions involving the ERBB family of RTKs h
Externí odkaz:
https://doaj.org/article/70a0b6cd821d4f078b9efca4a60b1301
Publikováno v:
Molecular Therapy: Oncolytics, Vol 22, Iss , Pp 1-12 (2021)
Immunotherapy in the metastatic setting has drastically altered the landscape of treatment for various types of malignancy, including colorectal cancer. The category of immune checkpoint inhibitors has especially emerged as a class of therapy predica
Externí odkaz:
https://doaj.org/article/d862693ae9ea4444acf2ebfd5334cfd7
Autor:
Ariella M. Altman MD, McKenzie J. White MD, Schelomo Marmor PhD, MPH, Dip Shukla MD, Katherine Chang MD, Emil Lou MD, Christopher J. LaRocca MD, Jane Y.C. Hui MD, MS, Todd M. Tuttle MD, MS, Eric H. Jensen MD, Jason W. Denbo MD
Publikováno v:
Cancer Control, Vol 29 (2022)
Background It is unclear whether the addition of chemoradiation (CRT) to adjuvant chemotherapy (CT) following upfront resection of pancreatic ductal adenocarcinoma (PDAC) provides any benefit. While some studies have suggested a benefit to combined m
Externí odkaz:
https://doaj.org/article/4ce64fca9933462bb2e01bf41701afe6
Autor:
Udhayvir Singh Grewal, Arjun Gupta, Jamie Doggett, Emil Lou, Niraj J Gusani, Anirban Maitra, Muhammad Shaalan Beg, Allyson J Ocean
Publikováno v:
JMIR Cancer, Vol 8, Iss 1, p e31388 (2022)
Background There is a growing interest in the pattern of consumption of health-related information on social media platforms. ObjectiveWe evaluated the content of discussions around pancreatic cancer on Twitter to identify subtopics of greatest inte
Externí odkaz:
https://doaj.org/article/a6db031ee1794281ae62367933fd826c