Prolonged β-adrenergic stimulation disperses ryanodine receptor clusters in cardiomyocytes and has implications for heart failure

Autor: Xin Shen, Jonas van den Brink, Anna Bergan-Dahl, Terje R Kolstad, Einar S Norden, Yufeng Hou, Martin Laasmaa, Yuriana Aguilar-Sanchez, Ann P Quick, Emil KS Espe, Ivar Sjaastad, Xander HT Wehrens, Andrew G Edwards, Christian Soeller, William E Louch

Publikováno v: eLife, Vol 11 (2022)

Ryanodine receptors (RyRs) exhibit dynamic arrangements in cardiomyocytes, and we previously showed that ‘dispersion’ of RyR clusters disrupts Ca2+ homeostasis during heart failure (HF) (Kolstad et al., eLife, 2018). Here, we investigated whether

Externí odkaz: https://doaj.org/article/8009cf35beb44a249e475603ed937272

Predicting left ventricular contractile function via Gaussian process emulation in aortic-banded rats

Autor: Longobardi, Stefano, Lewalle, Alexandre, Coveney, Sam, Sjaastad, Ivar, Emil KS, Espe, Louch, William Edward, Cynthia J, Musante, Anna, Sher, Niederer, Steven A.

Publikováno v: Longobardi, Stefano Lewalle, Alexandre Coveney, Sam Sjaastad, Ivar Emil KS, Espe Louch, William Edward Cynthia J, Musante Anna, Sher Niederer, Steven A. . Predicting left ventricular contractile function via Gaussian process emulation in aortic-banded rats. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences. 2020, 378(2173), 20190334
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences

Externí odkaz: http://hdl.handle.net/10852/82760
https://www.duo.uio.no/bitstream/handle/10852/82760/5/rsta.2019.0334.pdf