Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Emil Aagaard Thomsen"'
Autor:
Emil Aagaard Thomsen, Kristian Alsbjerg Skipper, Sofie Andersen, Didde Haslund, Thomas Wisbech Skov, Jacob Giehm Mikkelsen
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 563-576 (2022)
Locus-directed DNA cleavage induced by the CRISPR-Cas9 system triggers DNA repair mechanisms allowing gene repair or targeted insertion of foreign DNA. For gene insertion to be successful, availability of a homologous donor template needs to be timed
Externí odkaz:
https://doaj.org/article/3aa9eac12cbf4bfdaa1419c3d3f22f0f
Autor:
Emil Aagaard Thomsen, Sofie Andersen, Mikkel Haarslev Schröder Marqvorsen, Kristian Alsbjerg Skipper, Søren R. Paludan, Jacob Giehm Mikkelsen
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2022)
The innate immune system represents a balanced first line of defense against infection. Type I interferons (IFNs) are key regulators of the response to viral infections with an essential early wave of IFN-β expression, which is conditional, time-res
Externí odkaz:
https://doaj.org/article/a1bef718c4734a61b25cf6b27e5fabcf
Autor:
Emil Aagaard Thomsen, Anne Bruun Rovsing, Mads Valdemar Anderson, Hanne Due, Jinrong Huang, Yonglun Luo, Karen Dybkær, Jacob Giehm Mikkelsen
Publikováno v:
Molecular Oncology, Vol 14, Iss 9, Pp 1978-1997 (2020)
Diffuse large B‐cell lymphoma (DLBCL) is characterized by extensive genetic heterogeneity, and this results in unpredictable responses to the current treatment, R‐CHOP, which consists of a cancer drug combination supplemented with the humanized C
Externí odkaz:
https://doaj.org/article/db68e49e73e744989b9cfb52fe01b91f
Autor:
Jonas Holst Wolff, Jakob Haldrup, Emil Aagaard Thomsen, Sofie Andersen, Jacob Giehm Mikkelsen
Publikováno v:
Frontiers in Genome Editing, Vol 3 (2021)
Prime editing is a novel genome editing technology that allows a wide range of tailored genomic alterations. Prime editing does not involve homologous recombination, but suffers from low efficacy. Here, we demonstrate piggyPrime, a transfected single
Externí odkaz:
https://doaj.org/article/1e9f9970af5f4f1bbb8f20886290ab8a
Autor:
Andreas Holmgaard, Anne Louise Askou, Josephine Natalia Esther Benckendorff, Emil Aagaard Thomsen, Yujia Cai, Toke Bek, Jacob Giehm Mikkelsen, Thomas J. Corydon
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 9, Iss C, Pp 89-99 (2017)
Virus-based gene therapy by CRISPR/Cas9-mediated genome editing and knockout may provide a new option for treatment of inherited and acquired ocular diseases of the retina. In support of this notion, we show that Streptococcus pyogenes (Sp) Cas9, del
Externí odkaz:
https://doaj.org/article/161da74f106c4bfcac63b2f9d8bea9df
Autor:
Malene Blond Ipsen, Ea Marie Givskov Sørensen, Emil Aagaard Thomsen, Simone Weiss, Jakob Haldrup, Anders Dalby, Johan Palmfeldt, Peter Bross, Martin Rasmussen, Jacob Fredsøe, Søren Klingenberg, Mads R. Jochumsen, Kirsten Bouchelouche, Benedicte Parm Ulhøi, Michael Borre, Jacob Giehm Mikkelsen, Karina Dalsgaard Sørensen
Publikováno v:
Ipsen, M B, Sørensen, E M G, Thomsen, E A, Weiss, S, Haldrup, J, Dalby, A, Palmfeldt, J, Bross, P, Rasmussen, M, Fredsøe, J, Klingenberg, S, Jochumsen, M R, Bouchelouche, K, Ulhøi, B P, Borre, M, Mikkelsen, J G & Sørensen, K D 2022, ' A genome-wide CRISPR-Cas9 knockout screen identifies novel PARP inhibitor resistance genes in prostate cancer ', Oncogene, vol. 41, no. 37, pp. 4271-4281 . https://doi.org/10.1038/s41388-022-02427-2
DNA repair gene mutations are frequent in castration-resistant prostate cancer (CRPC), suggesting eligibility for poly(ADP-ribose) polymerase inhibitor (PARPi) treatment. However, therapy resistance is a major clinical challenge and genes contributin
Autor:
Anne Bruun Rovsing, Emil Aagaard Thomsen, Ian Nielsen, Thomas Wisbech Skov, Yonglun Luo, Karen Dybkær, Jacob Giehm Mikkelsen
The frontline therapy R-CHOP for patients with diffuse large B-cell lymphoma (DLBCL) has remained unchanged for two decades despite numerous phase III clinical trials investigating new alternatives. Multiple large studies have uncovered genetic subty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8d3b8b702e902fe91a616b839246150
https://doi.org/10.1101/2023.01.19.524713
https://doi.org/10.1101/2023.01.19.524713
Autor:
Troels Boldt Rømer, Fawzi Khoder-Agha, Mikkel Koed Møller Aasted, Noortje de Haan, Sabrina Horn, August Dylander, Tao Zhang, Emil Marek Heymans Pallesen, Sally Dabelsteen, Manfred Wuhrer, Christine Flodgaard Høgsbro, Emil Aagaard Thomsen, Jacob Giehm Mikkelsen, Hans H Wandall
Publikováno v:
Glycobiology.
In epithelial cancers, truncated O-glycans, such as the Thomson-nouveau antigen (Tn) and its sialylated form (STn), are up-regulated on the cell surface and associated with poor prognosis and immunological escape. Recent studies have shown that these
Autor:
Lisa Loksø Dietz, Natasja Toft Furman, Trine Vilsbøll Larsen, Tina Fuglsang Daugaard, Emil Aagaard Thomsen, Johanne Lade Keller, Lars Aagaard, Boe Sandahl Sorensen, Anders Lade Nielsen
Publikováno v:
Dietz, L L, Furman, N T, Larsen, T V, Daugaard, T F, Thomsen, E A, Keller, J L, Aagaard, L, Sorensen, B S & Nielsen, A L 2022, ' An Extended PD-L2 Cytoplasmic Domain Results From Alternative Splicing in NSCLC Cells ', Journal of Immunotherapy, vol. 45, no. 9, pp. 379-388 . https://doi.org/10.1097/CJI.0000000000000439
Antibody-based immunotherapy targeting the interaction between programmed cell death 1 (PD-1) and its ligand PD-L1 has shown impressive clinical outcomes in various cancer types, including nonsmall cell lung cancer (NSCLC). However, regulatory mechan
Autor:
Jakob Haldrup, Jacob Giehm Mikkelsen, Jonas Holst Wolff, Sofie Andersen, Emil Aagaard Thomsen
Publikováno v:
Frontiers in Genome Editing
Frontiers in Genome Editing, Vol 3 (2021)
Frontiers in Genome Editing, Vol 3 (2021)
Prime editing is a novel genome editing technology that allows a wide range of tailored genomic alterations. Prime editing does not involve homologous recombination, but suffers from low efficacy. Here, we demonstrate piggyPrime, a transfected single