Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Emil A. Russoman"'
Autor:
Kurt Hollfelder, Mary C. Graves, Seth P. Monkarsh, Pascal Bailon, Palleroni Alicia Vallejo, Emil A. Russoman, Jill E. Porter, Yuemei Ma, Yu-Ching E. Pan, Doreen Ciolek, Hanspeter Michel, Swapan K. Roy, Barabara Debarbieri, Anthony Aglione
Publikováno v:
Analytical Biochemistry. 247:434-440
The success of recombinant interferon alpha in the clinic in part is limited by two properties of the protein: short serum half-life and immunogenicity. To improve these properties, interferon alpha-2a was conjugated with polyethylene glycol (PEG-500
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::246368842f1b7396edb4e8997684a7bc
https://doi.org/10.1006/abio.1997.2128
https://doi.org/10.1006/abio.1997.2128
Publikováno v:
Journal of chromatography. 631(1-2)
A chromatofocusing-like method used in the large-scale separation of deamidated from amidated recombinant human interleukin-1α (amino acids 117-271), derived from Escherichia coli , is described. Two major protein species having isoelectric points (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe66cb1cdf3eed4c2bd24a7c054c3a20
https://pubmed.ncbi.nlm.nih.gov/8450021
https://pubmed.ncbi.nlm.nih.gov/8450021