Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Emiko Okuda-Ashitaka"'
Autor:
Hideo Hagihara, Hirotaka Shoji, Satoko Hattori, Giovanni Sala, Yoshihiro Takamiya, Mika Tanaka, Masafumi Ihara, Mihiro Shibutani, Izuho Hatada, Kei Hori, Mikio Hoshino, Akito Nakao, Yasuo Mori, Shigeo Okabe, Masayuki Matsushita, Anja Urbach, Yuta Katayama, Akinobu Matsumoto, Keiichi I Nakayama, Shota Katori, Takuya Sato, Takuji Iwasato, Haruko Nakamura, Yoshio Goshima, Matthieu Raveau, Tetsuya Tatsukawa, Kazuhiro Yamakawa, Noriko Takahashi, Haruo Kasai, Johji Inazawa, Ikuo Nobuhisa, Tetsushi Kagawa, Tetsuya Taga, Mohamed Darwish, Hirofumi Nishizono, Keizo Takao, Kiran Sapkota, Kazutoshi Nakazawa, Tsuyoshi Takagi, Haruki Fujisawa, Yoshihisa Sugimura, Kyosuke Yamanishi, Lakshmi Rajagopal, Nanette Deneen Hannah, Herbert Y Meltzer, Tohru Yamamoto, Shuji Wakatsuki, Toshiyuki Araki, Katsuhiko Tabuchi, Tadahiro Numakawa, Hiroshi Kunugi, Freesia L Huang, Atsuko Hayata-Takano, Hitoshi Hashimoto, Kota Tamada, Toru Takumi, Takaoki Kasahara, Tadafumi Kato, Isabella A Graef, Gerald R Crabtree, Nozomi Asaoka, Hikari Hatakama, Shuji Kaneko, Takao Kohno, Mitsuharu Hattori, Yoshio Hoshiba, Ryuhei Miyake, Kisho Obi-Nagata, Akiko Hayashi-Takagi, Léa J Becker, Ipek Yalcin, Yoko Hagino, Hiroko Kotajima-Murakami, Yuki Moriya, Kazutaka Ikeda, Hyopil Kim, Bong-Kiun Kaang, Hikari Otabi, Yuta Yoshida, Atsushi Toyoda, Noboru H Komiyama, Seth GN Grant, Michiru Ida-Eto, Masaaki Narita, Ken-ichi Matsumoto, Emiko Okuda-Ashitaka, Iori Ohmori, Tadayuki Shimada, Kanato Yamagata, Hiroshi Ageta, Kunihiro Tsuchida, Kaoru Inokuchi, Takayuki Sassa, Akio Kihara, Motoaki Fukasawa, Nobuteru Usuda, Tayo Katano, Teruyuki Tanaka, Yoshihiro Yoshihara, Michihiro Igarashi, Takashi Hayashi, Kaori Ishikawa, Satoshi Yamamoto, Naoya Nishimura, Kazuto Nakada, Shinji Hirotsune, Kiyoshi Egawa, Kazuma Higashisaka, Yasuo Tsutsumi, Shoko Nishihara, Noriyuki Sugo, Takeshi Yagi, Naoto Ueno, Tomomi Yamamoto, Yoshihiro Kubo, Rie Ohashi, Nobuyuki Shiina, Kimiko Shimizu, Sayaka Higo-Yamamoto, Katsutaka Oishi, Hisashi Mori, Tamio Furuse, Masaru Tamura, Hisashi Shirakawa, Daiki X Sato, Yukiko U Inoue, Takayoshi Inoue, Yuriko Komine, Tetsuo Yamamori, Kenji Sakimura, Tsuyoshi Miyakawa
Publikováno v:
eLife, Vol 12 (2024)
Increased levels of lactate, an end-product of glycolysis, have been proposed as a potential surrogate marker for metabolic changes during neuronal excitation. These changes in lactate levels can result in decreased brain pH, which has been implicate
Externí odkaz:
https://doaj.org/article/15de117935204a21a8487997042e8094
Autor:
Hiroki Kamada, Kousuke Emura, Rikuto Yamamoto, Koichi Kawahara, Sadahito Uto, Toshiaki Minami, Seiji Ito, Ken-ichi Matsumoto, Emiko Okuda-Ashitaka
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Deficiency of an extracellular matrix glycoprotein tenascin-X (TNX) leads to a human heritable disorder Ehlers–Danlos syndrome, and TNX-deficient patients complain of chronic joint pain, myalgia, paresthesia, and axonal polyneuropathy. We
Externí odkaz:
https://doaj.org/article/05ac6b7462934fa48b269f7704dd23bf
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Tenascin-X (TNX) is an extracellular matrix glycoprotein for which a deficiency results in a recessive form of classical-like Ehlers-Danlos syndrome (clEDS), a heritable connective tissue disorder with hyperextensible skin without atrophic scarring,
Externí odkaz:
https://doaj.org/article/416239f7e5dc4fb29525c5ffb361a4f4
Autor:
Naoki Miura, Kota Nakatomi, Yuto Ishikawa, Salunya Tancharoen, Ikuro Maruyama, Ko-ichi Kawahara, Ronny Christiadi Salim, Hikari Ueno, Issey Kanemoto, Yoshihiro Motomiya, Kiyoshi Kikuchi, Kiyoshi Matsumura, Yuki Mori, Hitoshi Imaizumi, Emiko Okuda‑Ashitaka, Taketo Omori
Publikováno v:
Biomedical Reports
Nucleophosmin 1 (NPM1) primarily localizes to the nucleus and is passively released into the extracellular milieu by necrotic or damaged cells, or is secreted by monocytes and macrophages. Extracellular NPM1 acts as a potent inflammatory stimulator b
Autor:
Hiroaki Kakumoto, Toshiaki Minami, Shota Yamanishi, Seiji Ito, Hiroki Kamada, Naoya Ogura, Satoshi Matsukawa, Takafumi Yoshidu, Yuka Kakuchi, Sadahito Uto, Emiko Okuda-Ashitaka, Ken-ichi Matsumoto
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Tenascin-X (TNX) is a member of the extracellular matrix glycoprotein tenascin family, and TNX deficiency leads to Ehlers-Danlos syndrome, a heritable human disorder characterized mostly by skin hyperextensibility, joint hypermobility, and easy bruis
Publikováno v:
Biochemical and Biophysical Research Communications. 501:514-519
Nocistatin (NST) is a neuropeptide produced from the same precursor protein of opioid peptide nociceptin/orphanin FQ, and it is involved in a broad range of central functions including pain transmission in the nervous system. However, the composition
Autor:
Toshiaki Minami, Isamu Nishimura, Kenta Kawabata, Takeshi Fujiwara, Seiji Ito, Shoko Terauchi, Emiko Okuda-Ashitaka
Publikováno v:
European Journal of Neuroscience. 43:1499-1508
Pathological chronic pain, which is frequently associated with prolonged tissue damage, inflammation, tumour invasion, and neurodegenerative diseases, gives rise to hyperalgesia and allodynia. We previously reported that intrathecal administration of
Autor:
Toshiaki Minami, Arisa Takeuchi, Kana Ohno, Masaki Ohashi, Seiji Ito, Kazuya Okamoto, Emiko Okuda-Ashitaka, Etsuko Matsuoka, Kyohei Fujisato
Publikováno v:
Molecular Pain
Background Chronic pain associated with inflammation is an important clinical problem, and the underlying mechanisms remain poorly understood. 4-Nitrophenylphosphatase domain and nonneuronal SNAP25-like protein homolog (NIPSNAP) 1, an interacting pro
Autor:
Hiroshi Handa, Tetsuo Noda, Shingo Tsubouchi, Seiji Ito, Akihiro Iwamatsu, Toshiaki Minami, Hiroshi Kiyonari, Emiko Okuda-Ashitaka
Publikováno v:
Journal of Biological Chemistry. 287:10403-10413
4-Nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (NIPSNAP1) is a molecule of physiologically unknown function, although it is predominantly expressed in the brain, spinal cord, liver, and kidney. We identified NIPSNAP1 a
Autor:
Emiko Okuda-Ashitaka, Shunji Kunori, Seiji Ito, Yoshihiro Urade, Tayo Katano, Laurent P. Audoly, Shinji Matsumura
Publikováno v:
Glia. 59:208-218
Neuropathic pain produced by damage to or dysfunction of the nervous system is a common and severely disabling state that affects millions of people worldwide. Recent evidence indicates that activated microglia are key cellular intermediaries in the