Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Emiko Miyahara"'
Autor:
Takuro Nishikawa, Emiko Miyahara, Ieharu Yamazaki, Kazuro Ikawa, Shunsuke Nakagawa, Yuichi Kodama, Yoshifumi Kawano, Yasuhiro Okamoto
Publikováno v:
Diseases, Vol 12, Iss 5, p 85 (2024)
The pathogenesis of cyclophosphamide (CY)-induced cardiotoxicity remains unknown, and methods for its prevention have not been established. To elucidate the acute structural changes that take place in myocardial cells and the pathways leading to myoc
Externí odkaz:
https://doaj.org/article/b336b9aa697f456f93e25672498f1198
Publikováno v:
BMC Research Notes, Vol 10, Iss 1, Pp 1-10 (2017)
Abstract Background The dose-limiting toxic effect of cyclophosphamide (CY) is cardiotoxicity. The pathogenesis of myocardial damage is poorly understood, and there is no established means of prevention. In previous studies, we suggested that for CY-
Externí odkaz:
https://doaj.org/article/3dc88e95253d413799c0d3b1f11961e6
Autor:
Takuro Nishikawa, Emiko Miyahara, Koichiro Kurauchi, Erika Watanabe, Kazuro Ikawa, Kousuke Asaba, Takayuki Tanabe, Yasuhiro Okamoto, Yoshifumi Kawano
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0131394 (2015)
Observed only after administration of high doses, cardiotoxicity is the dose-limiting effect of cyclophosphamide (CY). We investigated the poorly understood cardiotoxic mechanisms of high-dose CY. A rat cardiac myocardial cell line, H9c2, was exposed
Externí odkaz:
https://doaj.org/article/9d9b875de67b4d158abd1f7d4f1d56a8
Autor:
Takuro Nishikawa, Emiko Miyahara, Ieharu Yamazaki, Hiroko Hagiwara, Kazuro Ikawa, Shunsuke Nakagawa, Yuichi Kodama, Yoshifumi Kawano, Yasuhiro Okamoto
The pathogenesis of cyclophosphamide (CY)-induced cardiotoxicity remains unknown, and methods for its prevention have not been established. To elucidate acute structural changes in myocardial cells and pathways leading to myocardial damage in mice tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75e78ac93da4cdd4a76a8e8dcf65881f
https://doi.org/10.21203/rs.3.rs-1629925/v1
https://doi.org/10.21203/rs.3.rs-1629925/v1
Publikováno v:
BMC Research Notes, Vol 10, Iss 1, Pp 1-10 (2017)
BMC Research Notes
BMC Research Notes
Background The dose-limiting toxic effect of cyclophosphamide (CY) is cardiotoxicity. The pathogenesis of myocardial damage is poorly understood, and there is no established means of prevention. In previous studies, we suggested that for CY-induced c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daa85a74a7172ff56d89949512b74521
http://link.springer.com/article/10.1186/s13104-017-2726-2
http://link.springer.com/article/10.1186/s13104-017-2726-2
Autor:
Kazutaka Nakayama, Hiroki Yamaguchi, Yasuo Takeda, Takayuki Tanabe, Takuro Nishikawa, Yasuhiro Okamoto, Shunsuke Nakagawa, Yuichi Kodama, Erika Higashi, Akari Shigemi, Kazuro Ikawa, Emiko Miyahara, Yoshifumi Kawano, Takanari Abematsu, Yuichi Shinkoda
Publikováno v:
Pediatrics international : official journal of the Japan Pediatric Society. 61(6)
BACKGROUND Fatal adverse effects or relapse can occur with excessive or insufficient busulfan exposure in hematopoietic stem cell transplantation. Given that busulfan is mainly metabolized by glutathione S-transferase (GST), we investigated the influ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cf5f4055bacfb6965085344954d240a
https://pubmed.ncbi.nlm.nih.gov/31464056
https://pubmed.ncbi.nlm.nih.gov/31464056
Autor:
Masahisa Horiuchi, Takuro Nishikawa, Kimiko Izumo, Yoshifumi Kawano, Yasuhiro Okamoto, Yoshichika Kawai, Toru Takeuchi, Emiko Miyahara
Publikováno v:
Environmental Health Perspectives
Background: Although benzene is known to be myelotoxic and to cause myeloid leukemia in humans, the mechanism has not been elucidated. Objectives: We focused on 1,2,4-benzenetriol (BT), a benzene metabolite that generates reactive oxygen species (ROS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf2284ee58095f3af363671b2a5f6a9b
https://doi.org/10.1289/ehp.1103437
https://doi.org/10.1289/ehp.1103437
Autor:
Takayuki Tanabe, Koichiro Kurauchi, Takanari Abematsu, Takuro Nishikawa, Shunsuke Nakagawa, Yoshifumi Kawano, Yuichi Shinkoda, Yasuhiro Okamoto, Kazuro Ikawa, Emiko Miyahara, Yuichi Kodama
Publikováno v:
Biology of Blood and Marrow Transplantation. 23:S243-S244
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f281fb544d1e3b0b76acd193ea5f27f
https://doi.org/10.1016/j.bbmt.2016.12.475
https://doi.org/10.1016/j.bbmt.2016.12.475
Autor:
Minoru Takeuchi, Masahisa Horiuchi, Masaharu Komatsu, Makiko Nishie, Emiko Miyahara, Shota Takumi, Junichiro Nishi, Kiyotaka Yoshiie, Toru Takeuchi, Kohji Aoyama, Hiroaki Miyanohara, Hiroshi Oda
Publikováno v:
FEMS Microbiology Letters. 317:109-116
The emergence of drug-resistant microorganisms is an important medical and social problem. Drug-resistant microorganisms are thought to grow selectively in the presence of antibiotics. Most clinically isolated drug-resistant microorganisms have mutat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7f887f217b5f65e88d824885b33289b
https://doi.org/10.1111/j.1574-6968.2011.02215.x
https://doi.org/10.1111/j.1574-6968.2011.02215.x
Autor:
Kaori Yasuda, Yasuhiro Okamoto, Emiko Miyahara, Masahisa Horiuchi, Yoshifumi Kawano, Takuro Nishikawa, Toru Takeuchi
Publikováno v:
Toxicology. 317
While it is known that benzene induces myeloid leukemia in humans, the mechanism has yet to be clarified. Previously, we suggested that myeloperoxidase (MPO) was the key enzyme because it promotes generation of powerful oxidant hypochlorous acid (HOC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44665f82420b21a3aba700fc7c0dafc6
https://pubmed.ncbi.nlm.nih.gov/24530881
https://pubmed.ncbi.nlm.nih.gov/24530881