Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Emiko Mihara"'
Autor:
Nichole Marcela Rojas-Chaverra, Ryu Imamura, Hiroki Sato, Toby Passioura, Emiko Mihara, Tatsunori Nishimura, Junichi Takagi, Hiroaki Suga, Kunio Matsumoto, Katsuya Sakai
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110426- (2024)
Summary: The regenerative functions associated with cytokines and growth factors have immense therapeutic potential; however, their poor pharmacokinetics, resulting from structural features, hinder their effectiveness. In this study, we aimed to enha
Externí odkaz:
https://doaj.org/article/0d8d58bd76f444259d5c7598ca8e3f20
Autor:
Seung-Bum Ko, Emiko Mihara, Yedarm Park, Kyeonghwan Roh, Chanhee Kang, Junichi Takagi, Injin Bang, Hee-Jung Choi
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
The linker domain of Frizzled receptors has a varying effect on the functional levels of canonical and non-canonical Wnt signaling, with FZD chimeras influencing the binding of Wnt proteins and the recruitment of proteins regulating downstream signal
Externí odkaz:
https://doaj.org/article/080ac9acde79442fb05c5f4dde94f497
Autor:
Yusuke Higuchi, Tatsuya Suzuki, Takao Arimori, Nariko Ikemura, Emiko Mihara, Yuhei Kirita, Eriko Ohgitani, Osam Mazda, Daisuke Motooka, Shota Nakamura, Yusuke Sakai, Yumi Itoh, Fuminori Sugihara, Yoshiharu Matsuura, Satoaki Matoba, Toru Okamoto, Junichi Takagi, Atsushi Hoshino
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Hoshino et al., engineer a human virus receptor, hACE2, and demonstrate its potential for overcoming SARS-CoV-2 mutations that otherwise hinder therapeutic interventions. Overall, the data provide insights in to the therapeutic potential of engineere
Externí odkaz:
https://doaj.org/article/6dacf0dd324f4db5afbaae20298e4ac1
Autor:
Takao Arimori, Naoyuki Miyazaki, Emiko Mihara, Mamoru Takizawa, Yukimasa Taniguchi, Carlos Cabañas, Kiyotoshi Sekiguchi, Junichi Takagi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Recognition of laminin by integrin receptors mediates epithelial cell adhesion to basement membrane. Here, the structures of the α6β1 integrin alone and in complex with three-chain laminin-511 fragment reveal the laminin-integrin interface in molec
Externí odkaz:
https://doaj.org/article/687deb85420c4b6994fe618c35c25766
Autor:
Emiko Mihara, Satoshi Watanabe, Nasir K. Bashiruddin, Nozomi Nakamura, Kyoko Matoba, Yumi Sano, Rumit Maini, Yizhen Yin, Katsuya Sakai, Takao Arimori, Kunio Matsumoto, Hiroaki Suga, Junichi Takagi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
RaPID (Random non-standard Peptides Integrated Discovery) enables discovery of small macrocyclic peptides binding desired targets. Here, the authors propose lasso-grafting: the RaPID-derived peptides are implanted onto diverse proteins and maintain b
Externí odkaz:
https://doaj.org/article/b6402a431ea3401381e2112d57500bf8
Autor:
Yamato Komatsu, Naohiro Terasaka, Katsuya Sakai, Emiko Mihara, Risa Wakabayashi, Kunio Matsumoto, Donald Hilvert, Junichi Takagi, Hiroaki Suga
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103302- (2021)
Summary: Lasso-grafting (LG) technology is a method for generating de novo biologics (neobiologics) by genetically implanting macrocyclic peptide pharmacophores, which are selected in vitro against a protein of interest, into loops of arbitrary prote
Externí odkaz:
https://doaj.org/article/f66388c0f64b4cedba1f72a4ac812d78
Autor:
Masamichi Nagae, Yasuhiko Kizuka, Emiko Mihara, Yu Kitago, Shinya Hanashima, Yukishige Ito, Junichi Takagi, Naoyuki Taniguchi, Yoshiki Yamaguchi
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
The activity of glycosyltransferase GnT-V correlates with cancer malignancy and poor prognosis but its mechanism of action is poorly understood. Here, the authors solve crystal structures of free and substrate analog-bound GnT-V, providing insights i
Externí odkaz:
https://doaj.org/article/f1b4c8dd92254367b426de0599de41f5
Autor:
Emiko Mihara, Hidenori Hirai, Hideki Yamamoto, Keiko Tamura-Kawakami, Mami Matano, Akira Kikuchi, Toshiro Sato, Junichi Takagi
Publikováno v:
eLife, Vol 5 (2016)
Wnt plays important role during development and in various diseases. Because Wnts are lipidated and highly hydrophobic, they can only be purified in the presence of detergents, limiting their use in various in vitro and in vivo assays. We purified N-
Externí odkaz:
https://doaj.org/article/9b04a5fa9a914e4e98f0739e29aaa5bb
Autor:
Katsuya Sakai, Nozomi Sugano-Nakamura, Emiko Mihara, Nichole Marcela Rojas-Chaverra, Sayako Watanabe, Hiroki Sato, Ryu Imamura, Dominic Chih-Cheng Voon, Itsuki Sakai, Chihiro Yamasaki, Chise Tateno, Mikihiro Shibata, Hiroaki Suga, Junichi Takagi, Kunio Matsumoto
Publikováno v:
Nature Biomedical Engineering. 7:164-176
Short half-lives in circulation and poor transport across the blood–brain barrier limit the utility of cytokines and growth factors acting as receptor agonists. Here we show that surrogate receptor agonists with longer half-lives in circulation and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92f116ce64db52b76394e02f25b10633
https://doi.org/10.1038/s41551-022-00955-6
https://doi.org/10.1038/s41551-022-00955-6
Autor:
Tsubasa Tanaka, Toru Ekimoto, Meri Nagatomo, Makiko Neyazaki, Erena Shimoji, Tsutomu Yamane, Sakura Kanagawa, Rika Oi, Emiko Mihara, Junichi Takagi, Satoko Akashi, Mitsunori Ikeguchi, Terukazu Nogi
Publikováno v:
Protein science : a publication of the Protein Society. 31(11)
Semaphorins constitute a large family of secreted and membrane-bound proteins that signal through cell-surface receptors, plexins. Semaphorins generally use low-affinity protein-protein interactions to bind with their specific plexin(s) and regulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eea2f87ab249047c60d3be50fae4676
https://pubmed.ncbi.nlm.nih.gov/36156831
https://pubmed.ncbi.nlm.nih.gov/36156831