Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Emiko Kranz"'
Autor:
Emiko Kranz, Charles J. Kuhlmann, Joshua Chan, Patrick Y. Kim, Irvin S. Y. Chen, Masakazu Kamata
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Chimeric-antigen receptor (CAR) T-cell immunotherapy employs autologous-T cells modified with an antigen-specific CAR. Current CAR-T manufacturing processes tend to yield products dominated by effector T cells and relatively small proportions of long
Externí odkaz:
https://doaj.org/article/a1656d681fe741bb9e4556569cdda034
Autor:
Lan Wang, Jing Wen, Jie Ren, Emiko Kranz, Shilin Chen, Toshio Kanazawa, Irvin Chen, Yunfeng Lu, Masakazu Kamata
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 2 (2021)
Background Despite the numerous applications of monoclonal antibodies (mAbs) in cancer therapeutics, animal models available to test the therapeutic efficacy of new mAbs are limited. NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mice are one of the most hig
Externí odkaz:
https://doaj.org/article/e913defc66ea41f4a4af89a8552834da
Autor:
Meng Qin, Lan Wang, Di Wu, Christopher K. Williams, Duo Xu, Emiko Kranz, Qi Guo, Jiaoqiong Guan, Harry V. Vinters, YooJin Lee, Yiming Xie, Yun Luo, Guibo Sun, Xiaobo Sun, Zhanlong He, Yunfeng Lu, Masakazu Kamata, Jing Wen, Irvin S. Y. Chen
Publikováno v:
Frontiers in Immunology, Vol 10 (2020)
Tumor metastasis into the central nervous system (CNS) and lymph nodes (LNs) is a major obstacle for effective therapies. Therapeutic monoclonal antibodies (mAb) have revolutionized tumor treatment; however, their efficacy for treating metastatic tum
Externí odkaz:
https://doaj.org/article/12d7f398dcad4f9bb9c0eeee72da161b
Efficacy of Antibodies Targeting TfR1 in Xenograft Mouse Models of AIDS-Related Non-Hodgkin Lymphoma
Autor:
Tracy R. Daniels-Wells, Pierre V. Candelaria, Emiko Kranz, Jing Wen, Lan Wang, Masakazu Kamata, Juan C. Almagro, Otoniel Martínez-Maza, Manuel L. Penichet
Publikováno v:
Cancers, vol 15, iss 6
Cancers; Volume 15; Issue 6; Pages: 1816
Cancers; Volume 15; Issue 6; Pages: 1816
Transferrin receptor 1 (TfR1), also known as CD71, is a transmembrane protein involved in the cellular uptake of iron and the regulation of cell growth. This receptor is expressed at low levels on a variety of normal cells, but is upregulated on cell
Autor:
Masakazu Kamata, Jing Wen, Toshio Kanazawa, Irvin S. Y. Chen, Yunfeng Lu, Jie Ren, Shilin Chen, Emiko Kranz, Di Wu, Lan Wang
Publikováno v:
Journal for immunotherapy of cancer, vol 9, iss 2
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 2 (2021)
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 2 (2021)
BackgroundDespite the numerous applications of monoclonal antibodies (mAbs) in cancer therapeutics, animal models available to test the therapeutic efficacy of new mAbs are limited. NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mice are one of the most high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20025516fed56d29af28fcc04351c9a0
https://escholarship.org/uc/item/4hm153f0
https://escholarship.org/uc/item/4hm153f0
The use of chimeric antigen receptor modified-T (CAR-T) cells in adoptive immunotherapy has been popularized through recent success in the field of cancer treatment research. CD4ζ CAR, which targets HIV-1-infected cells, has been developed and evalu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5010bb0174b71e8c3ab00d3e7e966842
Autor:
Yunfeng Lu, Harry V. Vinters, Otoniel Martinez-Maza, Jing Wen, Xin Guan, Emiko Kranz, Duo Xu, Meng Qin, Di Wu, Guibo Sun, Masakazu Kamata, Lan Wang, Chaoyong Liu, Yang Liu, Irvin S. Y. Chen, Daniel P. Widney, YooJin Lee, Xiaobo Sun
Publikováno v:
Nature biomedical engineering, vol 3, iss 9
Nature biomedical engineering
Nature biomedical engineering
Approximately 15-40% of all cancers develop metastases in the central nervous system (CNS), yet few therapeutic options exist to treat them. Cancer therapies based on monoclonal antibodies are widely successful, yet have limited efficacy against CNS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07ad5de3f267ca659e31e9deeb7b7c24
https://escholarship.org/uc/item/8p38d2sb
https://escholarship.org/uc/item/8p38d2sb
Autor:
Manuel L. Penichet, Juan Carlos Almagro, Otoniel Martinez-Maza, Lan Weng, Masakazu Kamata, Emiko Kranz, Pierre V. Candelaria, Tracy R. Daniels-Wells, Jing Wen
Publikováno v:
Cancer Research. 80:5655-5655
Infection with the human immunodeficiency virus (HIV) and the development of acquired immunodeficiency syndrome (AIDS) increases the risk of developing B-cell lymphomas. AIDS-related B-cell non-Hodgkin lymphoma (AIDS-NHL) remains a significant clinic
Autor:
Patrick Y. Kim, Otto O. Yang, Emiko Kranz, Masakazu Kamata, Sean M. O'connor, Gene-Errol Ringpis, Hwee L. Ng, Irvin S. Y. Chen, Joshua Chan
Publikováno v:
Biochemical and Biophysical Research Communications. 463:216-221
Chimeric antigen receptors (CARs) are artificially engineered receptors that confer a desired specificity to immune effector T cells. As an HIV-1-specific CAR, CD4ζ CAR has been extensively tested in vitro as well as in clinical trials. T cells modi