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Mass Spectrometric Enzyme Histochemistry Method Developed for Visualizing In Situ Cholinesterase Activity in Mus musculus and Drosophila melanogaster

Autor: Eiichiro Fukusaki, Shuichi Shimma, Emi Takeo

Publikováno v: Analytical Chemistry. 92:12379-12386

Enzyme histochemistry facilitates enzyme activity visualization in situ; however, as it is a color-based method, molecular quantification is prohibitive. This study aimed to develop a semiquantitative, mass spectrometry imaging (MSI)-based enzyme his

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a64053e128d81be2b92bea00b4d295e
https://doi.org/10.1021/acs.analchem.0c02106

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Tandem Mass Spectrometry Imaging Reveals Distinct Accumulation Patterns of Steroid Structural Isomers in Human Adrenal Glands

Autor: Sumio Ohtsuki, Koshiro Nishimoto, Masanori Yasuda, Eiji Sugiyama, Makoto Suematsu, Emi Takeo, Shuichi Shimma, Yuki Sugiura, Tatsuya Higashi, Tetsuo Nishikawa, Eiichiro Fukusaki, Tatsuki Uemura

Publikováno v: Analytical Chemistry. 91:8918-8925

Visualizing tissue distribution of steroid hormones is a promising application of MALDI mass spectrometry imaging (MSI). On-tissue chemical derivatization using Girard's T reagent has enhanced the ionization efficiency of steroids. However, discrimin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f34dd77a9207691b78c7b806723a9e83
https://doi.org/10.1021/acs.analchem.9b00619

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Mass Spectrometric Enzyme Histochemistry for Choline Acetyltransferase Reveals

Autor: Emi, Takeo, Yuki, Sugiura, Yuichiro, Ohnishi, Haruhiko, Kishima, Eiichiro, Fukusaki, Shuichi, Shimma

Publikováno v: ACS chemical neuroscience. 12(12)

Choline acetyltransferase (ChAT), responsible for the synthesis of acetylcholine, plays an important role in neurotransmission. However, no method to visualize the ChAT activity in tissues has been reported to date. In this study, mass spectrometry i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::56df2aef59e20d0c5dad095c8d27737d
https://pubmed.ncbi.nlm.nih.gov/34078081

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Melittin Induced G1 Cell Cycle Arrest and Apoptosis in Chago-K1 Human Bronchogenic Carcinoma Cells and Inhibited the Differentiation of THP-1 Cells into Tumour- Associated Macrophages

Autor: Arin Wongprommoon, Chanpen Chanchao, Teeranai Ittiudomrak, Songchan Puthong, Chartsiam Tipgomut, Emi Takeo

Publikováno v: Asian Pacific Journal of Cancer Prevention : APJCP

Background: Bronchogenic carcinoma (lung cancer) is one of the leading causes of death. Although many compounds isolated from natural products have been used to treat it, drug resistance is a serious problem, and alternative anti-cancer drugs are req

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ffbe40529114657e96054fc764f4b8f
https://doi.org/10.31557/apjcp.2018.19.12.3427

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Aldosterone and 18-Oxocortisol Coaccumulation in Aldosterone-Producing Lesions

Autor: Takeo Kosaka, Shuichi Shimma, Emi Takeo, Tsugio Seki, Yuki Sugiura, Masao Omura, Mototsugu Oya, Yosuke Mizuno, Koshiro Nishimoto, Mai Yokota, Tetsuo Nishikawa, Tatsuya Higashi, Makoto Suematsu

Publikováno v: Hypertension. 72:1345-1354

Primary aldosteronism is a secondary hypertensive disease caused by autonomous aldosterone production that often caused by an aldosterone-producing adenoma (APA). Immunohistochemistry of aldosterone synthase (CYP11B2) shows the presence of aldosteron

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4617f6029a1d5df77c07c022b515c5a
https://doi.org/10.1161/hypertensionaha.118.11243

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