Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Emi Nakahara"'
Autor:
Miguel Miron-Mendoza, Kara Poole, Sophie DiCesare, Emi Nakahara, Meet Paresh Bhatt, John D. Hulleman, Walter Matthew Petroll
Publikováno v:
Cells, Vol 13, Iss 13, p 1094 (2024)
Vimentin has been reported to play diverse roles in cell processes such as spreading, migration, cell–matrix adhesion, and fibrotic transformation. Here, we assess how vimentin impacts cell spreading, morphology, and myofibroblast transformation of
Externí odkaz:
https://doaj.org/article/6e2992c7c5164c4183bca6ee0999bf15
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Distinct mutations in the secreted extracellular matrix protein, fibulin-3 (F3), have been associated with a number of ocular diseases ranging from primary open angle glaucoma to cuticular age-related macular degeneration to a rare macular d
Externí odkaz:
https://doaj.org/article/f4d1cbf2ae3f44988272f1e62004c969
Utility of the DHFR-based destabilizing domain across mouse models of retinal degeneration and aging
Autor:
Hui Peng, Prerana Ramadurgum, DaNae R. Woodard, Steffi Daniel, Emi Nakahara, Marian Renwick, Bogale Aredo, Shyamtanu Datta, Bo Chen, Rafael Ufret-Vincenty, John D. Hulleman
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104206- (2022)
Summary: The Escherichia coli dihydrofolate reductase (DHFR) destabilizing domain (DD) serves as a promising approach to conditionally regulate protein abundance in a variety of tissues. To test whether this approach could be effectively applied to a
Externí odkaz:
https://doaj.org/article/c66749c64c8e4e949da4813d0329bdb2
Publikováno v:
ACS Chemical Biology. 17:2877-2889
Destabilizing domains (DDs) are an attractive strategy allowing for positive post-transcriptional small molecule-regulatable control of a fusion protein's abundance. However, in many instances, the currently available DDs suffer from higher-than-desi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79ae3dffef12aabe1b741e76f8399986
https://doi.org/10.1021/acschembio.2c00518
https://doi.org/10.1021/acschembio.2c00518
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
Scientific Reports
Distinct mutations in the secreted extracellular matrix protein, fibulin-3 (F3), have been associated with a number of ocular diseases ranging from primary open angle glaucoma to cuticular age-related macular degeneration to a rare macular dystrophy,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::701ef35636951b6a4e7b56dec3753be8
https://doaj.org/article/f4d1cbf2ae3f44988272f1e62004c969
https://doaj.org/article/f4d1cbf2ae3f44988272f1e62004c969
Autor:
DaNae R. Woodard, Steffi Daniel, Emi Nakahara, Ali Abbas, Sophia M. DiCesare, Gracen E. Collier, John D. Hulleman
Publikováno v:
Human mutationREFERENCES. 43(12)
Fibulin-3 (F3 or EFEMP1) is a disulfide-rich, secreted glycoprotein necessary for maintaining extracellular matrix (ECM) and connective tissue integrity. Three studies have identified distinct autosomal recessive F3 mutations in individuals with Marf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abe76d62dee4a3bc88e9229c28d6c2f8
https://pubmed.ncbi.nlm.nih.gov/35998264
https://pubmed.ncbi.nlm.nih.gov/35998264
Autor:
Emi Nakahara, John D. Hulleman
Publikováno v:
Curr Eye Res
PURPOSE: A lack of sufficient information exists for appropriately classifying a large number of myocilin (MYOC) variants, and their involvement in primary open angle glaucoma, hindering their definitive classification. Most glaucoma-causing MYOC mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23a018d28b5647a1d0cb1835e2d8f980
https://europepmc.org/articles/PMC9743483/
https://europepmc.org/articles/PMC9743483/
Autor:
John Hulleman, Emi Nakahara
With the increasing use of molecular genetics approaches for determination of potential disease-causing mutations, it is becoming more important to be able to interpret and act upon the provided results. As an example of such an instance, nearly 300
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a0b1a96fdbadae512783962a6592a08
https://doi.org/10.1101/2021.10.30.466573
https://doi.org/10.1101/2021.10.30.466573