Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Emi Inagaki"'
Autor:
Shintaro Yamaguchi, Junichiro Irie, Masanori Mitsuishi, Yuichi Uchino, Hideaki Nakaya, Ryo Takemura, Emi Inagaki, Shotaro Kosugi, Hideyuki Okano, Masato Yasui, Kazuo Tsubota, Kaori Hayashi, Jun Yoshino, Hiroshi Itoh
Publikováno v:
Endocrine Journal, Vol 71, Iss 2, Pp 153-169 (2024)
Obesity and aging are major risk factors for several life-threatening diseases. Accumulating evidence from both rodents and humans suggests that the levels of nicotinamide adenine dinucleotide (NAD+), a regulator of many biological processes, decline
Externí odkaz:
https://doaj.org/article/92235c5b076e4e6488506b52c2421753
Autor:
Saki Sakakura, Emi Inagaki, Tomoko Sayano, Risa Yamazaki, Noemi Fusaki, Shin Hatou, Masatoshi Hirayama, Kazuo Tsubota, Kazuno Negishi, Hideyuki Okano, Shigeto Shimmura
Publikováno v:
Regenerative Therapy, Vol 24, Iss , Pp 592-601 (2023)
Introduction: Fuchs endothelial corneal dystrophy (FECD) is the leading cause of corneal blindness in developed countries. Corneal endothelial cells in FECD are susceptive to oxidative stress, leading to mitochondrial dysfunction and cell death. Oxid
Externí odkaz:
https://doaj.org/article/7a365db3a838401b9291b1fd913b44dd
Autor:
Saki Sakakura, Emi Inagaki, Yuichiro Ochiai, Masatoshi Yamamoto, Naofumi Takai, Taeko Nagata, Kazunari Higa, Yasunori Sato, Hiroshi Toshida, Dogru Murat, Masatoshi Hirayama, Yoko Ogawa, Kazuno Negishi, Shigeto Shimmura
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 22, p 16510 (2023)
Tear film instability is a major cause of dry eye disease. In order to treat patients with short tear film breakup time (TBUT)-type dry eye, the development of tear film stabilizing agents is essential. However, the lack of an appropriate animal mode
Externí odkaz:
https://doaj.org/article/6b5da6493af744c38b9ce59bccb497e5
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
In developed countries, the aging of the population and the associated increase in age-related diseases are causing major unresolved medical, social, and environmental matters. Therefore, research on aging has become one of the most important and urg
Externí odkaz:
https://doaj.org/article/962c41754c1f4824874cb5f73c37f174
Autor:
Shin Hatou, Tomoko Sayano, Kazunari Higa, Emi Inagaki, Yuji Okano, Yasunori Sato, Hideyuki Okano, Kazuo Tsubota, Shigeto Shimmura
Publikováno v:
Stem Cell Research, Vol 55, Iss , Pp 102497- (2021)
Objective: In order to provide regenerative therapy for millions of patients suffering from corneal blindness globally, we derived corneal endothelial cell substitute (CECSi) cells from induced pluripotent stem cells (iPSCs) to treat corneal edema du
Externí odkaz:
https://doaj.org/article/f5199bef44374887939298d2261c86e9
Autor:
Robert Maximilian Rusch, Yoko Ogawa, Shinri Sato, Satoru Morikawa, Emi Inagaki, Eisuke Shimizu, Kazuo Tsubota, Shigeto Shimmura
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9, p 4895 (2021)
Mesenchymal stem cells (MSCs) have been widely used in therapeutic applications for many decades. However, more and more evidence suggests that factors such as the site of origin and pre-implantation treatment have a crucial impact on the result. Thi
Externí odkaz:
https://doaj.org/article/88974c65b85d47e58fc292179c92d5bb
Autor:
Katsuya Yamazoe, Satoru Yoshida, Miyuki Yasuda, Shin Hatou, Emi Inagaki, Yoko Ogawa, Kazuo Tsubota, Shigeto Shimmura
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133397 (2015)
To investigate the phenotype and predisposing factors of a granular corneal dystrophy type 2 transgenic mouse model.Human TGFBI cDNA with R124H mutation was used to make a transgenic mouse expressing human protein (TGFBIR124H mouse). Reverse transcri
Externí odkaz:
https://doaj.org/article/fb8c1dd3eee845feb6ced61852f8e214
Publikováno v:
Keio Journal of Medicine; 2024, Vol. 73 Issue 1, p1-7, 7p
Publikováno v:
Frontiers in aging neuroscience. 14
In developed countries, the aging of the population and the associated increase in age-related diseases are causing major unresolved medical, social, and environmental matters. Therefore, research on aging has become one of the most important and urg
Autor:
Yo-ichi Nabeshima, Masato Yasui, Hiroshi Itoh, Kazuo Tsubota, Takashi Ono, Junichiro Irie, Masanori Mitsuishi, Hideaki Nakaya, Shin-ichiro Imai, Kazuya Yamashita, Hideyuki Okano, Shintaro Yamaguchi, Emi Inagaki, Hideo Yukioka, Shuhei Shigaki, Masataka Fujita
Publikováno v:
Endocrine Journal. 67:153-160
Recent studies have revealed that decline in cellular nicotinamide adenine dinucleotide (NAD+) levels causes aging-related disorders and therapeutic approaches increasing cellular NAD+ prevent these disorders in animal models. The administration of n