Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Emese Kis"'
Autor:
Afia Naseem, Akos Pal, Sharon Gowan, Yasmin Asad, Adam Donovan, Csilla Temesszentandrási-Ambrus, Emese Kis, Zsuzsanna Gaborik, Gurdip Bhalay, Florence Raynaud
Publikováno v:
Cells, Vol 11, Iss 20, p 3286 (2022)
Caco-2 screens are routinely used in laboratories to measure the permeability of compounds and can identify substrates of efflux transporters. In this study, we hypothesized that efflux transporter inhibition of a compound can be predicted by an intr
Externí odkaz:
https://doaj.org/article/607381ec02564b09b33df71ee4a144ba
Publikováno v:
Molecular Pharmacology. 98:234-242
We previously established that androgen glucuronides are primarily effluxed by MRP2 and MRP3 in liver and intestine. However, no data exist on the mechanism of hepatic uptake of these metabolites. To fill this knowledge gap, the first goal of this st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8f9c48605bf9328e22048d0b2969e23
https://doi.org/10.1124/mol.120.119891
https://doi.org/10.1124/mol.120.119891
Autor:
Flavia Storelli, Cindy Yanfei Li, Madhav Sachar, Vineet Kumar, Scott Heyward, Zsolt Sáfár, Emese Kis, Jashvant D. Unadkat
Publikováno v:
Clinical pharmacology and therapeutics. 112(3)
To assess efficacy and toxicity of a drug in humans, it is important to measure the tissue concentration of a drug at the target site. For a drug that is transported into or out of the tissue, the tissue unbound steady-state concentration can be dram
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a75ece3e4997603a5b1f0511316d617
https://pubmed.ncbi.nlm.nih.gov/35152400
https://pubmed.ncbi.nlm.nih.gov/35152400
Publikováno v:
Expert Opinion on Drug Metabolism & Toxicology. 15:313-328
ABCG2 has a broad substrate specificity and is one of the most important efflux proteins modulating pharmacokinetics of drugs, nutrients and toxicokinetics of toxicants. ABCG2 is an important player in transporter-mediated drug-drug interactions (tDD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdd39577d27b8a1349c05a4eff0d12e0
https://doi.org/10.1080/17425255.2019.1591373
https://doi.org/10.1080/17425255.2019.1591373
Autor:
Zsuzsanna Gáborik, Emile Plise, Luna Musib, Emese Kis, Taleah Farasyn, Rucha Sane, Kit Wun Kathy Cheung, Annamaria Bui, Peter Kovacs, Ruina Li
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 48(12)
Organic anion-transporting polypeptide (OATP) 1B1/3-mediated drug-drug interaction (DDI) potential is evaluated in vivo with rosuvastatin (RST) as a probe substrate in clinical studies. We calibrated our assay with RST and estradiol 17-β-D-glucuroni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c34af0b13cd9f825b56bf72765490e0d
https://pubmed.ncbi.nlm.nih.gov/33037044
https://pubmed.ncbi.nlm.nih.gov/33037044
Autor:
Zsuzsanna Gáborik, Kazuya Ishida, Emese Kis, Cindy Yanfei Li, Vineet Kumar, Jashvant D. Unadkat
Publikováno v:
The AAPS journal. 22(5)
During drug development, in vivo human biliary drug clearances (CL) are usually predicted using human sandwich-cultured hepatocytes (SCH). To do so, SCH are pre-incubated with Ca2+-containing or Ca2+-free buffer to maintain or disrupt canalicular tig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::736fe8a85af7d2fad24e1bb916d6fd07
https://pubmed.ncbi.nlm.nih.gov/32808154
https://pubmed.ncbi.nlm.nih.gov/32808154
Publikováno v:
J Steroid Biochem Mol Biol
Testosterone glucuronide (TG), androsterone glucuronide (AG), etiocholanolone glucuronide (EtioG) and dihydrotestosterone glucuronide (DHTG) are the major metabolites of testosterone (T), which are excreted in urine and bile. Glucuronides can be deco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b8be54f40eeacce295dc1381a656711
https://pubmed.ncbi.nlm.nih.gov/30959153
https://pubmed.ncbi.nlm.nih.gov/30959153
Publikováno v:
Drug Metabolism and Pharmacokinetics. 35:S91
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ce95f7550604b3447361188a7dcaec1
https://doi.org/10.1016/j.dmpk.2020.04.229
https://doi.org/10.1016/j.dmpk.2020.04.229
Autor:
Ildikó Makai, Emese Kis, Zsolt Fekete, Jennifer R. Pratt, Petra Pádár, Erzsébet Beéry, Éva D. Molnár, Márton Jani, Zsolt Sáfár, Peter Krajcsi, Annamaria Bui
Publikováno v:
Journal of pharmaceutical sciences. 107(11)
Breast cancer resistance protein (BCRP) is a point of interest in drug-drug interaction safety testing. Therefore, a consensus probe that can be applied as victim in multiple experimental settings is of great benefit. Identification of candidates has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8988ff941fb09df1bc3f98a789cc002e
https://pubmed.ncbi.nlm.nih.gov/30708037
https://pubmed.ncbi.nlm.nih.gov/30708037
Autor:
Erzsébet Beéry, Peter Krajcsi, Bhavana Jagota, Teresa Heslop, Emese Kis, Richard J. Weaver, B. Kevin Park, Márton Jani, Beáta Tóth
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 46
The transport of bile acids facilitated by NTCP is an important factor in establishing bile flow. In this study, we examine the kinetics associated with human NTCP-dependent transport of two quantitatively important bile acids comprising the human bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::159d063bff3e3d91f592006c6015e378
https://pubmed.ncbi.nlm.nih.gov/29024779
https://pubmed.ncbi.nlm.nih.gov/29024779