TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage

Autor: Luc Negroni, Kapil Gupta, Boris Lenhard, Tao Ye, Stéphane D. Vincent, Petra Hajkova, Nevena Cvetesic, Imre Berger, Changwei Yu, Laszlo Tora, Ferenc Müller, Vincent Hisler, Emese Gazdag

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11, pp.6439. ⟨10.1038/s41467-020-20239-4⟩
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.6439. ⟨10.1038/s41467-020-20239-4⟩
Nature Communications, 2020, 11 (1), pp.6439. ⟨10.1038/s41467-020-20239-4⟩
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature communications

During oocyte growth, transcription is required to create RNA and protein reserves to achieve maternal competence. During this period, the general transcription factor TATA binding protein (TBP) is replaced by its paralogue, TBPL2 (TBP2 or TRF3), whi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0178b824902393d141e6dace6cbee978
https://doi.org/10.1038/s41467-020-20239-4

Activation of a T-box-Otx2-Gsc gene network independent of TBP and TBP-related factors

Autor: Gert Jan C. Veenstra, Daniel L. Weeks, Ila van Kruijsbergen, Ulrike G. Jacobi, Emese Gazdag

Publikováno v: Development (Cambridge, England)
Development, 143, 1340-50
Development, 143, 8, pp. 1340-50

Embryonic development relies on activating and repressing regulatory influences that are faithfully integrated at the core promoter of individual genes. In vertebrates, the basal machinery recognizing the core promoter includes TATA-binding protein (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e3da037e1cc198d695e3562eab9e57c
http://europepmc.org/articles/PMC4852510

The mammalian-specific Tex19.1 gene plays an essential role in spermatogenesis and placenta-supported development

Autor: Emmanuelle Kieffer, Rosy El Ramy, Catherine Celebi, Stéphane Viville, Déborah Bourc'his, Mayada Achour, Emese Gazdag, Aafke P.A. van Montfoort, Manuel Mark, Marius Teletin, Natasha Zamudio, Yara Tarabay, Philippe Tropel

Publikováno v: Human Reproduction, 28, 8, pp. 2201-2214
Human Reproduction, 28, 2201-2214

STUDY QUESTION What is the consequence of Tex19.1 gene deletion in mice? SUMMARY ANSWER The Tex19.1 gene is important in spermatogenesis and placenta-supported development. WHAT IS KNOWN ALREADY Tex19.1 is expressed in embryonic stem (ES) cells, prim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::366200c7256fea702fddc289f347469e
https://hdl.handle.net/2066/120015

Analysis of TATA-binding protein 2 (TBP2) and TBP expression suggests different roles for the two proteins in regulation of gene expression during oogenesis and early mouse development

Autor: Emese Gazdag, Aleksandar Rajkovic, Laszlo Tora, Maria-Elena Torres-Padilla

Publikováno v: Reproduction
Reproduction, BioScientifica, 2007, 134 (1), pp.51-62. ⟨10.1530/REP-06-0337⟩

Gametogenesis, the process during which germ cells are generated is essential for reproduction. In mammals, maternal mRNA and proteins present in the oocyte are required to ensure the progression of development until the embryo activates its genome a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f8e595d8aaf97fedb327c1a22c555bc
https://hal.archives-ouvertes.fr/hal-00188979