Zobrazeno 1 - 10
of 226
pro vyhledávání: '"Emery H. Bresnick"'
Autor:
Ruiqi Liao, Abiola Babatunde, Stephanie Qiu, Hamsini Harikumar, Joshua J. Coon, Katherine A. Overmyer, Yusuf A. Hannun, Chiara Luberto, Emery H. Bresnick
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Transcriptional mechanisms controlling developmental processes establish and maintain proteomic networks, which can govern the levels of intracellular small molecules. Although dynamic changes in bioactive small molecules can link transcript
Externí odkaz:
https://doaj.org/article/13af0e79e3c44252bf0bbbf743e9c8b7
Autor:
Mabel Minji Jung, Siqi Shen, Giovanni A. Botten, Thomas Olender, Koichi R. Katsumura, Kirby D. Johnson, Alexandra A. Soukup, Peng Liu, Qingzhou Zhang, Zena D. Jensvold, Peter W. Lewis, Robert A. Beagrie, Jason K.K. Low, Lihua Yang, Joel P. Mackay, Lucy A. Godley, Marjorie Brand, Jian Xu, Sunduz Keles, Emery H. Bresnick
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 7 (2023)
Although certain human genetic variants are conspicuously loss of function, decoding the impact of many variants is challenging. Previously, we described a patient with leukemia predisposition syndrome (GATA2 deficiency) with a germline GATA2 variant
Externí odkaz:
https://doaj.org/article/0a1d39017eb14888912ea7fe69a08151
Autor:
Vu L. Tran, Peng Liu, Koichi R. Katsumura, Erin Kim, Bjorn M. Schoff, Kirby D. Johnson, Emery H. Bresnick
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106297- (2023)
Summary: Innate immune signaling protects against pathogens, controls hematopoietic development, and functions in oncogenesis, yet the relationship between these mechanisms is undefined. Downregulating the GATA2 transcription factor in fetal hematopo
Externí odkaz:
https://doaj.org/article/5f3b08aa83854df7811358f16b3aa550
Autor:
Julio Castaño, Sergi Aranda, Clara Bueno, Fernando J. Calero-Nieto, Eva Mejia-Ramirez, Jose Luis Mosquera, Enrique Blanco, Xiaonan Wang, Cristina Prieto, Lorea Zabaleta, Elisabetta Mereu, Meritxell Rovira, Senda Jiménez-Delgado, Daniel R. Matson, Holger Heyn, Emery H. Bresnick, Berthold Göttgens, Luciano Di Croce, Pablo Menendez, Angel Raya, Alessandra Giorgetti
Publikováno v:
Stem Cell Reports, Vol 13, Iss 3, Pp 515-529 (2019)
Summary: In vertebrates, GATA2 is a master regulator of hematopoiesis and is expressed throughout embryo development and in adult life. Although the essential role of GATA2 in mouse hematopoiesis is well established, its involvement during early huma
Externí odkaz:
https://doaj.org/article/3c12a065cf724a05845be10b176cf5d3
Autor:
Emery H. Bresnick, Kirby D. Johnson
Publikováno v:
Blood Advances, Vol 3, Iss 13, Pp 2045-2056 (2019)
Abstract: Intensive scrutiny of human genomes has unveiled considerable genetic variation in coding and noncoding regions. In cancers, including those of the hematopoietic system, genomic instability amplifies the complexity and functional consequenc
Externí odkaz:
https://doaj.org/article/2098c9d956cc40e09af1bef20ba31a55
Autor:
Ruiqi Liao, Ye Zheng, Xin Liu, Yuannyu Zhang, Gretchen Seim, Nobuyuki Tanimura, Gary M. Wilson, Peiman Hematti, Joshua J. Coon, Jing Fan, Jian Xu, Sunduz Keles, Emery H. Bresnick
Publikováno v:
Cell Reports, Vol 31, Iss 13, Pp 107832- (2020)
Summary: Protein ensembles control genome function by establishing, maintaining, and deconstructing cell-type-specific chromosomal landscapes. A plethora of small molecules orchestrate cellular functions and therefore may link physiological processes
Externí odkaz:
https://doaj.org/article/c40d0a6740c144fbb53f8f5496dba931
Autor:
Jinhua Liu, Yapu Li, Jingyuan Tong, Jie Gao, Qing Guo, Lingling Zhang, Bingrui Wang, Hui Zhao, Hongtao Wang, Erlie Jiang, Ryo Kurita, Yukio Nakamura, Osamu Tanabe, James Douglas Engel, Emery H. Bresnick, Jiaxi Zhou, Lihong Shi
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
LncRNAs modulate diverse physiological cellular processes, however, their involvement in heme-dependent processes are not yet clear. Here the authors reveal the role of lncRNA UCA1 in erythroid cell development.
Externí odkaz:
https://doaj.org/article/b77cd360ed4e47e48a6cfe13667efaf8
Autor:
Zhanping Lu, Courtney C. Hong, Guangyao Kong, Anna L.F.V. Assumpção, Irene M. Ong, Emery H. Bresnick, Jing Zhang, Xuan Pan
Publikováno v:
Cell Reports, Vol 22, Iss 6, Pp 1545-1559 (2018)
Summary: Yin yang 1 (YY1) is a ubiquitous transcription factor and mammalian polycomb group protein (PcG) with important functions to regulate embryonic development, lineage differentiation, and cell proliferation. YY1 mediates stable PcG-dependent t
Externí odkaz:
https://doaj.org/article/239ab9bb303d44a690efc5fa8f272d78
Autor:
Charu Mehta, Kirby D. Johnson, Xin Gao, Irene M. Ong, Koichi R. Katsumura, Skye C. McIver, Erik A. Ranheim, Emery H. Bresnick
Publikováno v:
Cell Reports, Vol 20, Iss 12, Pp 2966-2979 (2017)
Hematopoietic development requires the transcription factor GATA-2, and GATA-2 mutations cause diverse pathologies, including leukemia. GATA-2-regulated enhancers increase Gata2 expression in hematopoietic stem/progenitor cells and control hematopoie
Externí odkaz:
https://doaj.org/article/5f5db142b9614d63809ec53cb53732d3
Autor:
Koichi R. Katsumura, Irene M. Ong, Andrew W. DeVilbiss, Rajendran Sanalkumar, Emery H. Bresnick
Publikováno v:
Cell Reports, Vol 16, Iss 9, Pp 2428-2441 (2016)
The master regulatory transcription factor GATA-2 triggers hematopoietic stem and progenitor cell generation. GATA2 haploinsufficiency is implicated in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), and GATA2 overexpression portends
Externí odkaz:
https://doaj.org/article/03d9ad82289d4dafad3c908e67edd8bd