Tight-Binding Hydroxypyrazole HIV-1 Nef Inhibitors Suppress Viral Replication in Donor Mononuclear Cells and Reverse Nef-Mediated MHC-I Downregulation.

Autor: Shi H; Department of Microbiology and Molecular Genetics , University of Pittsburgh School of Medicine , Suite 523 Bridgeside Point II, 450 Technology Drive , Pittsburgh , Pennsylvania 15219 , United States., Tice CM; Fox Chase Chemical Diversity Center, Inc. , Pennsylvania Biotechnology Center , 3805 Old Easton Road , Doylestown , Pennsylvania 18902 , United States., Emert-Sedlak L; Department of Microbiology and Molecular Genetics , University of Pittsburgh School of Medicine , Suite 523 Bridgeside Point II, 450 Technology Drive , Pittsburgh , Pennsylvania 15219 , United States., Chen L; Department of Microbiology and Molecular Genetics , University of Pittsburgh School of Medicine , Suite 523 Bridgeside Point II, 450 Technology Drive , Pittsburgh , Pennsylvania 15219 , United States., Li WF; Department of Microbiology and Molecular Genetics , University of Pittsburgh School of Medicine , Suite 523 Bridgeside Point II, 450 Technology Drive , Pittsburgh , Pennsylvania 15219 , United States., Carlsen M; Fox Chase Chemical Diversity Center, Inc. , Pennsylvania Biotechnology Center , 3805 Old Easton Road , Doylestown , Pennsylvania 18902 , United States., Wrobel JE; Fox Chase Chemical Diversity Center, Inc. , Pennsylvania Biotechnology Center , 3805 Old Easton Road , Doylestown , Pennsylvania 18902 , United States., Reitz AB; Fox Chase Chemical Diversity Center, Inc. , Pennsylvania Biotechnology Center , 3805 Old Easton Road , Doylestown , Pennsylvania 18902 , United States., Smithgall TE; Department of Microbiology and Molecular Genetics , University of Pittsburgh School of Medicine , Suite 523 Bridgeside Point II, 450 Technology Drive , Pittsburgh , Pennsylvania 15219 , United States.

Publikováno v: ACS infectious diseases [ACS Infect Dis] 2020 Feb 14; Vol. 6 (2), pp. 302-312. Date of Electronic Publication: 2019 Dec 16.

Hydrogen Exchange Mass Spectrometry of Related Proteins with Divergent Sequences: A Comparative Study of HIV-1 Nef Allelic Variants.

Autor: Wales TE; Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, 02115, USA., Poe JA; Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA., Emert-Sedlak L; Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA., Morgan CR; Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, 02115, USA.; Genzyme Corporation, Framingham, MA, 01701-9322, USA., Smithgall TE; Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA., Engen JR; Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, 02115, USA. j.engen@neu.edu.

Publikováno v: Journal of the American Society for Mass Spectrometry [J Am Soc Mass Spectrom] 2016 Jun; Vol. 27 (6), pp. 1048-61. Date of Electronic Publication: 2016 Mar 31.

The identification of a two-gene prognostic model based on cisplatin resistance-related ceRNA network in small cell lung cancer.

Autor: Zhang, Yani^1,2 (AUTHOR), Zhu, Qizhi^1,2 (AUTHOR), Qi, Jian^1,2 (AUTHOR), Fu, Meng^1,2 (AUTHOR), Xu, Ao^3,4 (AUTHOR), Wang, Wei^3,4 (AUTHOR), Wang, Hongzhi^1,2,5 (AUTHOR), Nie, Jinfu^1,2,5 (AUTHOR), Hong, Bo^1,2,5 (AUTHOR) bhong@hmfl.ac.cn

Publikováno v: BMC Medical Genomics. 5/15/2023, Vol. 16 Issue 1, p1-12. 12p.

Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role.

Autor: Schmaier AA; Department of Medicine, Division of Cardiology, Division of Hematology, Institute for Medicine and Engineering, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA., Zou Z, Kazlauskas A, Emert-Sedlak L, Fong KP, Neeves KB, Maloney SF, Diamond SL, Kunapuli SP, Ware J, Brass LF, Smithgall TE, Saksela K, Kahn ML

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2009 Dec 15; Vol. 106 (50), pp. 21167-72. Date of Electronic Publication: 2009 Nov 25.

Allosteric loss-of-function mutations in HIV-1 Nef from a long-term non-progressor.

Autor: Trible RP; Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Emert-Sedlak L, Wales TE, Ayyavoo V, Engen JR, Smithgall TE

Publikováno v: Journal of molecular biology [J Mol Biol] 2007 Nov 16; Vol. 374 (1), pp. 121-9. Date of Electronic Publication: 2007 Sep 11.