Frequency of the TP53 R337H variant in sporadic breast cancer and its impact on genomic instability

Autor: Rubens Silveira de Lima, Carolina Prando, Stefanne Bortoletto, Iglenir J. Cavalli, Ana Paula Martins Sebastião, Cicero Urban, Emerson Wander Silva Soares, Heloisa Komechen, Bonald C. Figueiredo, Aline S. Fonseca, Ariana Centa, Carolina Mathias, Enilze M. Ribeiro, Luciane R. Cavalli

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports

The R337H is a TP53 germline pathogenic variant that has been associated with several types of cancers, including breast cancer. Our main objective was to determine the frequency of the R337H variant in sporadic breast cancer patients from Paraná st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b8b0e4b892fee2f545c09e1d6acefb
http://link.springer.com/article/10.1038/s41598-020-73282-y

XAF1 as a modifier of p53 function and cancer susceptibility

Autor: Patricia Ashton-Prolla, Tatiana Ei-Jaick B Costa, Madson Q. Almeida, Maria Nirvana Formiga, Berenice B. Mendonca, Kara N. Maxwell, Geoffrey Neale, Mariana M Paraizo, Andrew J. Murphy, Enzo Lalli, Meredith Yeager, Jinghui Zhang, Laurence Brugières, Ana Claudia Latronico, Jinling Wang, Wenan Chen, Carolina Mathias, Evadnie Rampersaud, Gang Wu, Dominique Vaur, Sharon A. Savage, Sahlua Volc, Vania Balderrama Brondani, Gabriela E. S. Felix, Camila Matzenbacher Bittar, Elena M. Stoffel, Enilze Maria de Souza Fonseca Ribeiro, Hector Salvador, Vicente Odone-Filho, Kristine Jones, Tobias Else, Kayla V. Hamilton, Alberto S. Pappo, Edenir Inêz Palmero, Guillermo L. Chantada, Karina Miranda Santiago, Emerson Wander Silva Soares, Moara Machado, Kim E. Nichols, Maria Isabel Achatz, Payal P. Klincha, Cintia Regina Niederauer Ramos, Kelvin C. de Andrade, Luis Kowalski, Raul C. Ribeiro, Heloisa Komechen, Aurelie Vogt, Jon P. Connelly, Yoan Diekmann, Márta Korbonits, Eric Letouzé, Maria Candida Barisson Villares Fragoso, Bonald C. Figueiredo, Carlos Rodriguez-Galindo, Ivy Zortéa S Parise, Cinzia Lavarino, Gerard P. Zambetti, Henrique de Campos Reis Galvão, Weiyin Zhou, Shondra M. Pruett-Miller, Michael R. Clay, Emilia M. Pinto, Mark G. Thomas, Jose Luis Fuster-Soler

Publikováno v: Science Advances
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu

The XAF1-E134* variant increases the cancer risk for carriers of the TP53-R337H allele.
Cancer risk is highly variable in carriers of the common TP53-R337H founder allele, possibly due to the influence of modifier genes. Whole-genome sequencing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bb9b87a026bef839378660581a1f6cc
http://fundanet.fsjd.org/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=17947

Anatomical variations of the axilla

Autor: Emerson Wander Silva Soares

Publikováno v: SpringerPlus

Purpose The present study aimed to measure the thickness of the subcutaneous adipose tissue (SAT) at the site of the surgical incision for axillary lymph node dissection (ALND) and to record potential anatomical variations in the medial cutaneous ner

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f27660eaa4d302217dff8c7a0120839
https://doi.org/10.1186/2193-1801-3-306

Ação do extrato de Jatropha gossypiifolia L. (pião roxo) na cicatrização de anastomose colônica: estudo experimental em ratos

Autor: Paulo Roberto Soltoski, Miguel Ângelo Agulham, Santiago Cirilo Nogueira Servin, Ricardo Lemos, Emerson Wander Silva Soares, Alexandre Coutinho Teixeira de Freitas, Orlando Jorge Martins Torres, Fábio Augusto de Carvalho, Jorge Eduardo Fouto Matias

Publikováno v: Acta Cirurgica Brasileira, Volume: 21 Supplement 3, Pages: 89-96, Published: 2006
Acta Cirúrgica Brasileira v.21 suppl.3 2006
Acta Cirúrgica Brasileira
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC

INTRODUÇÃO: A fitoterapia vem despertando crescente interesse na comunidade científica em relação às suas potenciais propriedades cicatriciais. Poucos são os estudos com metodologia científica existentes na literatura, constituindo-se assim u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0effce1e6b62bb2286c335689e3a249d
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502006000900012&lng=en&tlng=en

Morbidity after conventional dissection of axillary lymph nodes in breast cancer patients

Autor: Emerson Wander Silva Soares, Reginaldo José Andrade, Géser Vinícius Silva Soares, Ademar Dantas da Cunha, Luis Cesar Bredt, Hildebrando Massahiro Nagai

Publikováno v: World Journal of Surgical Oncology

Background Conventional axillary lymph node dissection (ALND) has recently become less radical. The treatment morbidity effects of reduced ALND aggressiveness are unknown. This article investigates the prevalence of the main complications of ALND: ly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e94c69857e57e3561858c8ac2c8c5f3b
http://europepmc.org/articles/PMC3986871