A Myt1 family transcription factor defines neuronal fate by repressing non-neuronal genes

Autor: Joo Lee, Caitlin A Taylor, Kristopher M Barnes, Ao Shen, Emerson V Stewart, Allison Chen, Yang K Xiang, Zhirong Bao, Kang Shen

Publikováno v: eLife, Vol 8 (2019)

Cellular differentiation requires both activation of target cell transcriptional programs and repression of non-target cell programs. The Myt1 family of zinc finger transcription factors contributes to fibroblast to neuron reprogramming in vitro. Her

Externí odkaz: https://doaj.org/article/4f9ef3ae95d8453cbf9c3ee0c9a0936f

Dsc E3 ligase localization to the Golgi requires the ATPase Cdc48 and cofactor Ufd1 for activation of sterol regulatory element-binding protein in fission yeast

Autor: Risa Burr, Sumana Raychaudhuri, Diedre Ribbens, Jason Ho, Peter J. Espenshade, Emerson V. Stewart

Publikováno v: Journal of Biological Chemistry. 292:16333-16350

Sterol regulatory element-binding proteins (SREBPs) in the fission yeast Schizosaccharomyces pombe regulate lipid homeostasis and the hypoxic response under conditions of low sterol or oxygen availability. SREBPs are cleaved in the Golgi through the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4353e5a03467f88b71f9bad5354d320d
https://doi.org/10.1074/jbc.m117.802025

A Myt1 family transcription factor defines neuronal fate by repressing non-neuronal genes

Autor: Zhirong Bao, Allison Chen, Kang Shen, Joo Myung Lee, Yang Kevin Xiang, Emerson V. Stewart, Caitlin A. Taylor, Ao Shen, Kristopher M. Barnes

Publikováno v: eLife, Vol 8 (2019)
eLife

Cellular differentiation requires both activation of target cell transcriptional programs and repression of non-target cell programs. The Myt1 family of zinc finger transcription factors contributes to fibroblast to neuron reprogramming in vitro. Her

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::943737a87df47c6dad257a55d244c16d
https://escholarship.org/uc/item/7qt5f2nj

Mga2 transcription factor regulates an oxygen-responsive lipid homeostasis pathway in fission yeast

Autor: Emerson V. Stewart, Wei Shao, Hans Kristian Hannibal-Bach, Peter J. Espenshade, Shan Zhao, Risa Burr, Christer S. Ejsing

Publikováno v: Burr, R, Stewart, E V, Shao, W, Zhao, S, Hannibal-Bach, H K, Ejsing, C S & Espenshade, P J 2016, ' Mga2 transcription factor regulates an oxygen-responsive lipid homeostasis pathway in fission yeast ', Journal of Biological Chemistry, vol. 291, no. 23, pp. 12171-12183 . https://doi.org/10.1074/jbc.M116.723650

Eukaryotic lipid synthesis is oxygen-dependent with cholesterol synthesis requiring 11 oxygen molecules and fatty acid desaturation requiring 1 oxygen molecule per double bond. Accordingly, organisms evaluate oxygen availability to control lipid home

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64ad387f296fd743e6e0f681a842b2d5
https://findresearcher.sdu.dk:8443/ws/files/125009325/Mga2_transcription_factor_regulates_an_oxygen_responsive_lipid_homeostasis_pathway_in_fission_yeast.pdf

Identification of twenty-three mutations in fission yeast Scap that constitutively activate SREBP

Autor: Emerson V. Stewart, Peter J. Espenshade, Adam Hughes

Publikováno v: Journal of Lipid Research, Vol 49, Iss 9, Pp 2001-2012 (2008)

The endoplasmic reticulum membrane protein SREBP cleavage-activating protein (Scap) senses sterols and regulates activation of sterol-regulatory element binding proteins (SREBPs), membrane-bound transcription factors that control lipid homeostasis in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea331cf9183a12b7fd12dbc4aa24a2ab
https://doi.org/10.1194/jlr.m800207-jlr200