Modulation of the chelatable Zn pool in the brain by diethyldithiocarbamate is associated with behavioral impairment in adult zebrafish

Autor: Maria Elisa Calcagnotto, Renato Dutra Dias, Letícia Ferreira Pettenuzzo, Diogo Losch de Oliveira, Robert L. Tanguay, Marcos M. Braga, João Rocha, Emerson S. Silva, Diogo O. Souza, Eduardo Pacheco Rico, Denis B. Rosemberg

Publikováno v: Toxicology Research. 4:317-325

The study of the effects of diethyldithiocarbamate (DEDTC) in some diseases has been in focus for many years. However, DEDTC is a metal chelator that can present neurotoxicity as side effect. Here we investigate the effect of DEDTC on the brain zinc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::17343dc769ef168fd1d1a49468755d49
https://doi.org/10.1039/c4tx00111g

A Dialógica como Princípio Metodológico Transdisciplinar na Pesquisa em Educação

Autor: Lucena, Ana Maria S., Saraiva, Emerson S. Silva, Almeida, Luís Sérgio C

Publikováno v: Millenium-Journal of Education, Technologies, and Health; 20º anos-2016; 179-196
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP
Millenium, Vol 0, Iss 50, Pp 179-196 (2016)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)

O presente trabalho apresenta a dialógica enquanto perspectiva de pesquisa transdiciplinar. O texto começa por referir o percurso seguido por Mikhail Bakthin, Paulo Freire, Edgar Morin e Basarab Nicolescu ao trabalharem a metodologia dialógica em

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::fb79aaf60dafd4db7747f1c32da240f7
https://revistas.rcaap.pt/millenium/article/view/9619

Brain zinc chelation by diethyldithiocarbamate increased the behavioral and mitochondrial damages in zebrafish subjected to hypoxia

Autor: Emerson S. Silva, Denis B. Rosemberg, Diogo O. Souza, Gabriel H. Schirmbeck, Renato Dutra Dias, Marcos M. Braga, João Rocha, Eduardo Pacheco Rico, Carlos Severo Dutra-Filho, Charles Budaszewski Pinto, Diogo Losch de Oliveira, Tarsila Barros Moraes

Publikováno v: Scientific Reports

The increase in brain levels of chelatable zinc (Zn) in dysfunctions involving oxygen deprivation has stimulated the treatment with Zn chelators, such as diethyldithiocarbamate (DEDTC). However, DEDTC is a redox-active compound and it should be bette

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a7e42fddf24281f1725d4c13d9d247e
https://doi.org/10.1038/srep20279