Anti‐nociceptive effect of kinin B 1 and B 2 receptor antagonists on peripheral neuropathy induced by paclitaxel in mice

Autor: Emerson Marcelo Motta, Allisson Freire Bento, Marianne N. Manjavachi, Fernanda R Malinsky, Rafael C. Dutra, Robson Costa, João Bosco Pesquero, João B. Calixto

Publikováno v: British Journal of Pharmacology. 164:681-693

In the current study, we investigated the role of both kinin B₁ and B₂ receptors in peripheral neuropathy induced by the chronic treatment of mice with paclitaxel a widely used chemotherapeutic agent.Chemotherapy-evoked hyperalgesia was induced b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abe165fa579077454e5592ce87168555
https://doi.org/10.1111/j.1476-5381.2011.01408.x

Antinociceptive Activity ofTrichilia catiguaHydroalcoholic Extract: New Evidence on Its Dopaminergic Effects

Autor: Luiz Francisco Pianowski, Alice Fialho Viana, João B. Calixto, Emerson Marcelo Motta, Izaque de Sousa Maciel, Maria M. Campos, Paulo César Leal

Publikováno v: Evidence-Based Complementary and Alternative Medicine, Vol 2011 (2011)
Evidence-based Complementary and Alternative Medicine : eCAM

Trichilia catiguais a native plant of Brazil; its barks are used by some local pharmaceutical companies to prepare tonic drinks, such as Catuama. The present study was addressed to evaluate the effects ofT. catiguahydroalcoholic extract in mouse noci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee7442cbff863eb5f9555cc80881d7a1
https://doi.org/10.1093/ecam/nep144

The role of kinin B1 and B2 receptors in the scratching behaviour induced by proteinase-activated receptor-2 agonists in mice

Autor: Hugo A. M. Torres, Robson Costa, João Bosco Pesquero, Marianne N. Manjavachi, João B. Calixto, Luiz Juliano, Denise Mollica Marotta, Emerson Marcelo Motta

Publikováno v: British Journal of Pharmacology. 159:888-897

Background and purpose: Activation of the proteinase-activated receptor-2 (PAR-2) induces scratching behaviour in mice. Here, we have investigated the role of kinin B1 and B2 receptors in the pruritogenic response elicited by activators of PAR-2. Exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b307dcd7e774cb0b08658393c37e09d
https://doi.org/10.1111/j.1476-5381.2009.00571.x

Activation of the alpha-7 nicotinic acetylcholine receptor (α7 nAchR) reverses referred mechanical hyperalgesia induced by colonic inflammation in mice

Autor: Robson Costa, João B. Calixto, Marianne N. Manjavachi, Emerson Marcelo Motta, Maíra Cola

Publikováno v: Neuropharmacology. 63(5)

In the current study, we investigated the effect of the activation of the alpha-7 nicotinic acetylcholine receptor (α7 nAchR) on dextran sulphate sodium (DSS)-induced colitis and referred mechanical hyperalgesia in mice. Colitis was induced in CD1 m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96c4c5eae8638dbcedfb98ed12f819ca
https://pubmed.ncbi.nlm.nih.gov/22722030

Role of ET(A) and ET(B) endothelin receptors on endothelin-1-induced potentiation of nociceptive and thermal hyperalgesic responses evoked by capsaicin in rats

Autor: Juliana Geremias Chichorro, Giles A. Rae, Emerson Marcelo Motta

Publikováno v: Neuroscience letters. 457(3)

Increasing evidence indicates that endothelin-1 (ET-1) activates nociceptive neurons and sensitizes them to different noxious stimuli, but involvement of TRPV1-dependent mechanisms in mediation of such effects is not yet fully understood. Here we rep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a260ba00ec656a35b7cbc11b4dfa206
https://pubmed.ncbi.nlm.nih.gov/19429182