Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Emeric J. Charles"'
Autor:
Chunyu Zhao, Abdul Bhuiya, Jennifer A. Doudna, Melanie Ott, Emeric J Charles, Ming X. Tan, Brittney W. Thornton, Patrick D. Hsu, Amanda Mok, Arturo M. Escajeda, María Díaz de León Derby, Katherine S. Pollard, Daniel A. Fletcher, David F. Savage, G. Renuka Kumar, Noam Prywes, Tina Y. Liu, Dylan C. J. Smock, Shineui Kim, John J Desmarais, Eli J Dugan, Parinaz Fozouni, Sungmin Son, Liana F. Lareau, Neil A. Switz, Andrew R. Harris, Stephanie I. Stephens, Maxim Armstrong, Jeffrey Shu, Shrutee Jakhanwal, Anthony T. Iavarone, Roger McIntosh, Shreeya Agrawal, Gavin J. Knott
Publikováno v:
Nat Chem Biol
Nature Chemical Biology
medRxiv
article-version (status) pre
article-version (number) 1
Nature Chemical Biology
medRxiv
article-version (status) pre
article-version (number) 1
Direct, amplification-free detection of RNA has the potential to transform molecular diagnostics by enabling simple on-site analysis of human or environmental samples. CRISPR-Cas nucleases offer programmable RNA-guided RNA recognition that triggers c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c785d1b2d3e9f64e47f040660076a9bd
https://europepmc.org/articles/PMC10184463/
https://europepmc.org/articles/PMC10184463/
Autor:
Rachael M Barry, Anne-Florence Bitbol, Alexander Lorestani, Emeric J Charles, Chris H Habrian, Jesse M Hansen, Hsin-Jung Li, Enoch P Baldwin, Ned S Wingreen, Justin M Kollman, Zemer Gitai
Publikováno v:
eLife, Vol 3 (2014)
CTP Synthetase (CtpS) is a universally conserved and essential metabolic enzyme. While many enzymes form small oligomers, CtpS forms large-scale filamentous structures of unknown function in prokaryotes and eukaryotes. By simultaneously monitoring Ct
Externí odkaz:
https://doaj.org/article/b1fca865183544e1af06193fccf8b717
Engineering improved Cas13 effectors for targeted post-transcriptional regulation of gene expression
Autor:
Dylan C. J. Smock, Shineui Kim, Jennifer A. Doudna, Gavin J. Knott, David F. Savage, Emeric J Charles
Cas13 is a family of unique RNA-targeting CRISPR-Cas effectors, making it an appealing tool for probing and perturbing RNA function. However only a few Cas13 homologs have been shown to mediate robust RNA targeting in human cells, suggesting that unk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0cfe25be65c6ba7a3042e0737bb4c9a
https://doi.org/10.1101/2021.05.26.445687
https://doi.org/10.1101/2021.05.26.445687
Autor:
Amanda Mok, G. Renuka Kumar, Eli J Dugan, Noam Prywes, Stephanie I. Stephens, Shreeya Agrawal, María Díaz de León Derby, Liana F. Lareau, John J Desmarais, Brittney W. Thornton, David F. Savage, Andrew R. Harris, Katherine S. Pollard, Roger McIntosh, Patrick D. Hsu, Abdul Bhuiya, Emeric J Charles, Gavin J. Knott, Parinaz Fozouni, Anthony T. Iavarone, Melanie Ott, Shineui Kim, Sungmin Son, Ming X. Tan, Tina Y. Liu, Neil A. Switz, Chunyu Zhao, Shrutee Jakhanwal, Arturo M. Escajeda, Maxim Armstrong, Jeffrey Shu, Dylan C. J. Smock, Jennifer A. Doudna, Daniel A. Fletcher
Publikováno v:
Nature Chemical Biology. 17:1210-1210
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e69823a25845fdf9d36025153b0066d
https://doi.org/10.1038/s41589-021-00882-8
https://doi.org/10.1038/s41589-021-00882-8
Publikováno v:
Nature methods, vol 13, iss 12
The ability to dynamically manipulate the transcriptome is important for studying how gene networks direct cellular functions and how network perturbations cause disease. Nuclease-dead CRISPR-dCas9 transcriptional regulators, while offering an approa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7e67f6f299db31022130e7f57324686
https://doi.org/10.1038/nmeth.4042
https://doi.org/10.1038/nmeth.4042
Autor:
Jong H. Park, Sisi Chen, Flavia Pichiorri, Tiffany Tsou, Matt Thomson, Paul Rivaud, Emeric J Charles, John R Haliburton
Publikováno v:
Proc Natl Acad Sci U S A
Single-cell measurement techniques can now probe gene expression in heterogeneous cell populations from the human body across a range of environmental and physiological conditions. However, new mathematical and computational methods are required to r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94b34a17cb3290149509fc8755a792e9
Autor:
Mitchell R. O’Connell, Emeric J Charles, Joshua C Cofsky, Alexandra East-Seletsky, James M. Holton, Gavin J. Knott, Jennifer A. Doudna
Publikováno v:
Nature structuralmolecular biology. 24(10)
CRISPR adaptive immune systems protect bacteria from infections by deploying CRISPR RNA (crRNA)-guided enzymes to recognize and cut foreign nucleic acids. Type VI-A CRISPR-Cas systems include the Cas13a enzyme, an RNA-activated ribonuclease (RNase) c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d29761aff0b0e4cc1e28130b752e58b1
https://pubmed.ncbi.nlm.nih.gov/28892041
https://pubmed.ncbi.nlm.nih.gov/28892041
Autor:
Jesse M Hansen, Emeric J. Charles, Enoch P. Baldwin, Hsin Jung Li, Alexander Lorestani, Anne-Florence Bitbol, Chris H. Habrian, Rachael M. Barry, Zemer Gitai, Justin M. Kollman, Ned S. Wingreen
Publikováno v:
Barry, RM; Bitbol, AF; Lorestani, A; Charles, EJ; Habrian, CH; Hansen, JM; et al.(2014). Large-scale filament formation inhibits the activity of CTP synthetase. eLife, 3(July2014), 1-19. doi: 10.7554/eLife.03638. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/1tc7h0fp
eLife
eLife, vol 3, iss July2014
eLife, Vol 3 (2014)
eLife
eLife, vol 3, iss July2014
eLife, Vol 3 (2014)
CTP Synthetase (CtpS) is a universally conserved and essential metabolic enzyme. While many enzymes form small oligomers, CtpS forms large-scale filamentous structures of unknown function in prokaryotes and eukaryotes. By simultaneously monitoring Ct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::312a70f09e0d0cf17f4b778a23b81679
http://www.escholarship.org/uc/item/1tc7h0fp
http://www.escholarship.org/uc/item/1tc7h0fp
Autor:
Zemer Gitai, Emeric J. Charles, Jesse M Hansen, Rachael M. Barry, Enoch P. Baldwin, Alexander Lorestani, Justin M. Kollman, Hsin-Jung Li, Ned S. Wingreen, Anne-Florence Bitbol, Chris H. Habrian
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29fade326f20f24001126039769ec964
https://doi.org/10.7554/elife.03638.036
https://doi.org/10.7554/elife.03638.036