Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Emerging Technologies, Methods, and Models"'
Autor:
Blanche C, Ip, Elizabeth, Leary, Benjamin, Knorlein, David, Reich, Vivian, Van, Joshua, Manning, Jeffrey R, Morgan
Publikováno v:
Toxicol Sci
Humans are consistently exposed to thousands of untested chemicals that have been detected in the follicular fluid of the ovaries, and can disrupt reproductive health. Human granulosa cells (GCs) are the functional unit of the ovarian follicle with s
Autor:
Shaun D. McCullough, David S Morgan, Hannah J Smith, Annie M. Jarabek, Elizabeth M. Martin, David Diaz-Sanchez, Emma C. Bowers, Lisa A. Dailey, Emily R Aungst
Publikováno v:
Toxicol Sci
Inhaled chemical/material exposures are a ubiquitous part of daily life around the world. There is a need to evaluate potential adverse effects of both single and repeat exposures for thousands of chemicals and an exponentially larger number of expos
Publikováno v:
Toxicological Sciences
A critical aspect of toxicity evaluation is developmental and reproductive toxicity (DART) testing. Traditionally, DART testing has been conducted in vivo in mammalian model systems. New legislation aimed at reducing animal use and the prohibitive co
Autor:
Kevin Yugulis, Tharacad S. Ramanarayanan, Andrew P. Kuprat, Paul M. Hinderliter, Senthil Kabilan, Sarah Suffield, Richard A. Corley
Publikováno v:
Toxicological Sciences
Regulatory agencies are considering alternative approaches to assessing inhalation toxicity that utilizes in vitro studies with human cells and in silico modeling in lieu of additional animal studies. In support of this goal, computational fluid-part
Autor:
Stephen S. Ferguson, Julie R. Rice, Bruce Alex Merrick, Paul E Dunlap, Michael J. DeVito, Nisha S. Sipes, David Crizer, Sreenivasa Ramaiahgari, Scott S. Auerbach
Publikováno v:
Toxicol Sci
Interpretation of untargeted metabolomics data from both in vivo and physiologically relevant in vitro model systems continues to be a significant challenge for toxicology research. Potency-based modeling of toxicological responses has served as a pi
Publikováno v:
Toxicol Sci
Testing for acute inhalation hazards is conducted in animals; however, a number of robust in vitro human cell-based alternatives have been developed and tested. These models range in complexity from cultures of cell lines or primary cells in air-liqu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d20dec4f164b40650031d0ceee44d8d3
https://europepmc.org/articles/PMC9154286/
https://europepmc.org/articles/PMC9154286/
Autor:
Fred Parham, B Collins, Barney Sparrow, Stephen S. Ferguson, William M. Gwinn, Scott S. Auerbach, Nick Machesky, Jenni Gorospe, Deepak Mav, Michele R Balik-Meisner, Esra Mutlu, Richard S. Paules, Sreenivasa Ramaiahgari, Michael J. DeVito, Ruchir R. Shah, John R. Bucher, Matthew D. Stout, Heather Toy, Suramya Waidyanatha, Georgia K. Roberts, Dhiral P. Phadke, Bruce Alex Merrick
Publikováno v:
Toxicol Sci
A 5-day in vivo rat model was evaluated as an approach to estimate chemical exposures that may pose minimal risk by comparing benchmark dose (BMD) values for transcriptional changes in the liver and kidney to BMD values for toxicological endpoints fr
Autor:
Richard Goldstein, Jason Wang, Amulya Kaza, Neel K. Prabhu, Alastair Khodabukus, Nenad Bursac, Vishal S. Vaidya
Publikováno v:
Toxicol Sci
Traditional serum biomarkers used to assess skeletal muscle damage, such as activity of creatine kinase (CK), lack tissue specificity and sensitivity, hindering early detection of drug-induced myopathies. Recently, a novel four-factor skeletal muscle
Autor:
Nurul A N Mohd Yusof, Christine L. Mummery, Leon G.J. Tertoolen, Jessica Nebel, Peter Clements, Eric I. Rossman, Umber Saleem, Ana Krotenberg Garcia, Kate Harris, Maria L. H. Vlaming, Karen McGlynn, Godfrey L. Smith, Xiaoping Xu, Puspita A Katili, Tessa de Korte, Francis L. Burton, Berend J. van Meer, Ingra Mannhardt, Arne Hansen, Chris Denning, Anthony Bahinski, Thomas Eschenhagen
Publikováno v:
Toxicological Sciences
Toxicological Sciences, 176(1), 103-123. OXFORD UNIV PRESS
Toxicological Sciences, 176(1), 103-123. Oxford University Press
Toxicological Sciences, 176(1), 103-123. OXFORD UNIV PRESS
Toxicological Sciences, 176(1), 103-123. Oxford University Press
Animal models are 78% accurate in determining whether drugs will alter contractility of the human heart. To evaluate the suitability of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) for predictive safety pharmacology, we quan
Publikováno v:
Toxicol Sci
Pregnane X receptor (PXR; NR1I2) is a nuclear receptor that regulates transcriptional responses to drug or xenobiotic exposure, including induction of CYP3A transcription, in many vertebrate species. PXR is activated by a wide range of ligands that d