Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Emerald Perlas"'
Striated muscle-specific base editing enables correction of mutations causing dilated cardiomyopathy
Autor:
Markus Grosch, Laura Schraft, Adrian Chan, Leonie Küchenhoff, Kleopatra Rapti, Anne-Maud Ferreira, Julia Kornienko, Shengdi Li, Michael H. Radke, Chiara Krämer, Sandra Clauder-Münster, Emerald Perlas, Johannes Backs, Michael Gotthardt, Christoph Dieterich, Maarten M. G. van den Hoogenhof, Dirk Grimm, Lars M. Steinmetz
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Dilated cardiomyopathy is the second most common cause for heart failure with no cure except a high-risk heart transplantation. Approximately 30% of patients harbor heritable mutations which are amenable to CRISPR-based gene therapy. However
Externí odkaz:
https://doaj.org/article/287d1894c5f548b689b58cdf403063c5
Autor:
Valeria Taliani, Giulia Buonaiuto, Fabio Desideri, Adriano Setti, Tiziana Santini, Silvia Galfrè, Leonardo Schirone, Davide Mariani, Giacomo Frati, Valentina Valenti, Sebastiano Sciarretta, Emerald Perlas, Carmine Nicoletti, Antonio Musarò, Monica Ballarino
Publikováno v:
eLife, Vol 12 (2023)
Long noncoding RNAs (lncRNAs) are emerging as critical regulators of heart physiology and disease, although the studies unveiling their modes of action are still limited to few examples. We recently identified pCharme, a chromatin-associated lncRNA w
Externí odkaz:
https://doaj.org/article/3a640cbf46f84fc6b023fb2546f9993f
Autor:
Emmy Tsang, Camilla Orlandini, Rahul Sureka, Alvaro H. Crevenna, Emerald Perlas, Izzie Prankerd, Maria E. Masferrer, Cornelius T. Gross
Publikováno v:
PLoS ONE, Vol 18, Iss 2 (2023)
The dorsal periaqueductal gray is a midbrain structure implicated in the control of defensive behaviors and the processing of painful stimuli. Electrical stimulation or optogenetic activation of excitatory neurons in dorsal periaqueductal gray result
Externí odkaz:
https://doaj.org/article/a97586d805d847a9af327c08130b31c8
Autor:
Alexander Neil Young, Emerald Perlas, Nerea Ruiz-Blanes, Andreas Hierholzer, Nicola Pomella, Belen Martin-Martin, Alessandra Liverziani, Joanna W. Jachowicz, Thomas Giannakouros, Andrea Cerase
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-8 (2021)
Young et al. report a new mouse model for Pelger-Huet anomaly, a genetic disorder caused by mutations in the Lamin B receptor gene (Lbr) that leads to abnormal neutrophil differentiation and skeletal defects. Using CRISPR/Cas-9 editing of Lbr, which
Externí odkaz:
https://doaj.org/article/a0388b7db1f045ad87ee722dcc675a86
Autor:
Rahul Dhandapani, Cynthia Mary Arokiaraj, Francisco J. Taberner, Paola Pacifico, Sruthi Raja, Linda Nocchi, Carla Portulano, Federica Franciosa, Mariano Maffei, Ahmad Fawzi Hussain, Fernanda de Castro Reis, Luc Reymond, Emerald Perlas, Simone Garcovich, Stefan Barth, Kai Johnsson, Stefan G. Lechner, Paul A. Heppenstall
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
There are several classes of sensory neuron that contribute to pain states. Here, the authors demonstrate that TrkB+ sensory neurons detect light touch under normal conditions in mice but contribute to hypersensitivity in models of chronic pain, and
Externí odkaz:
https://doaj.org/article/fe4dc2a3ccaf4f5496713ff8538a5861
Autor:
Laura Batti, Mayya Sundukova, Emanuele Murana, Sofia Pimpinella, Fernanda De Castro Reis, Francesca Pagani, Hong Wang, Eloisa Pellegrino, Emerald Perlas, Silvia Di Angelantonio, Davide Ragozzino, Paul A. Heppenstall
Publikováno v:
Cell Reports, Vol 15, Iss 12, Pp 2608-2615 (2016)
Neuropathic pain is a widespread chronic pain state that results from injury to the nervous system. Spinal microglia play a causative role in the pathogenesis of neuropathic pain through secretion of growth factors and cytokines. Here, we investigate
Externí odkaz:
https://doaj.org/article/1d1b0263c2c847a8acf2da728efd01e5
Autor:
Alessandra Guidi, Cristiana Lalli, Emerald Perlas, Giulia Bolasco, Martina Nibbio, Edith Monteagudo, Alberto Bresciani, Giovina Ruberti
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 8, p e0004928 (2016)
Schistosomiasis, one of the world's greatest human neglected tropical diseases, is caused by parasitic trematodes of the genus Schistosoma. A unique feature of schistosome biology is that the induction of sexual maturation as well as the maintenance
Externí odkaz:
https://doaj.org/article/60eb0a8fc97547b48dcf02cad2e684e1
Autor:
Stefano Comazzetto, Monica Di Giacomo, Kasper Dindler Rasmussen, Christian Much, Chiara Azzi, Emerald Perlas, Marcos Morgan, Dónal O'Carroll
Publikováno v:
PLoS Genetics, Vol 10, Iss 10, p e1004597 (2014)
Male fertility requires the continuous production of high quality motile spermatozoa in abundance. Alterations in all three metrics cause oligoasthenoteratozoospermia, the leading cause of human sub/infertility. Post-mitotic spermatogenesis inclusive
Externí odkaz:
https://doaj.org/article/02729a72e6344132b5756a9e628216bf
Autor:
Giulia Buonaiuto, Valeria Taliani, Fabio Desideri, Adriano Setti, Tiziana Santini, Silvia Galfrè, Leonardo Schirone, Davide Mariani, Giacomo Frati, Valentina Valenti, Sebastiano Sciarretta, Emerald Perlas, Carmine Nicoletti, Antonio Musarò, Monica Ballarino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68a9ddd04d744f459a2caf8c257c8b49
https://doi.org/10.7554/elife.81360.sa2
https://doi.org/10.7554/elife.81360.sa2
Autor:
Urte Neniskyte, Ugne Kuliesiute, Auguste Vadisiute, Kristina Jevdokimenko, Ludovico Coletta, Senthilkumar Deivasigamani, Daina Pamedytyte, Neringa Daugelaviciene, Daiva Dabkeviciene, Emerald Perlas, Aditya Bali, Bernadette Basilico, Alessandro Gozzi, Davide Ragozzino, Cornelius T Gross
Publikováno v:
EMBO journal, Hoboken : John Wiley and Sons Inc, 2023, first published online, p. [1-18]
The mature mammalian brain connectome emerges during development via the extension and pruning of neuronal connections. Glial cells have been identified as key players in the phagocytic elimination of neuronal synapses and projections. Recently, phos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59d987acba0bf3ec068cd42004ac3228
https://repository.vu.lt/VU:ELABAPDB167790364&prefLang=en_US
https://repository.vu.lt/VU:ELABAPDB167790364&prefLang=en_US