Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Emer S Ferro"'
Autor:
Andrea S Heimann, Achla Gupta, Ivone Gomes, Rayees Rahman, Avner Schlessinger, Emer S Ferro, Ellen M Unterwald, Lakshmi A Devi
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0193322 (2018)
[This corrects the article DOI: 10.1371/journal.pone.0187306.].
Externí odkaz:
https://doaj.org/article/a4558e9d7a874c83a917827c4a4bba35
Autor:
Andrea S Heimann, Achla Gupta, Ivone Gomes, Rahman Rayees, Avner Schlessinger, Emer S Ferro, Ellen M Unterwald, Lakshmi A Devi
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187306 (2017)
The N-terminal region of G protein-coupled receptors can be efficiently targeted for the generation of receptor-selective antibodies. These antibodies are useful for the biochemical characterization of the receptors. In this study, we developed a set
Externí odkaz:
https://doaj.org/article/a02462ed03164899bafd13870378401e
Autor:
Sayani Dasgupta, Ciyu Yang, Leandro M Castro, Alexandre K Tashima, Emer S Ferro, Robyn D Moir, Ian M Willis, Lloyd D Fricker
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163312 (2016)
Peptides function as signaling molecules in species as diverse as humans and yeast. Mass spectrometry-based peptidomics techniques provide a relatively unbiased method to assess the peptidome of biological samples. In the present study, we used a qua
Externí odkaz:
https://doaj.org/article/963777c8a9844402ae8af96bb042329c
Autor:
Sayani Dasgupta, Michael A Fishman, Hana Mahallati, Leandro M Castro, Alexandre K Tashima, Emer S Ferro, Lloyd D Fricker
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145333 (2015)
Huntington's disease is the result of a long polyglutamine tract in the gene encoding huntingtin protein, which in turn causes a large number of cellular changes and ultimately results in neurodegeneration of striatal neurons. Although many theories
Externí odkaz:
https://doaj.org/article/485f4f8a08234278ba9c7ce9dbb9178d
Autor:
Sara eXapelli, Fabienne eAgasse, Sofia eGrade, Liliana eBernardino, Filipa eRibeiro, Clarissa S Schitine, Andrea eHeimann, Emer S Ferro, Ana M Sebastião, Ricardo A de Melo Reis, João O. Malva
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 8 (2014)
Neural stem cells (NSCs) from the subventricular zone (SVZ) have been indicated as a source of new oligodendrocytes to use in regenerative medicine for myelin pathologies. Indeed, NSCs are multipotent cells that can self-renew and differentiate into
Externí odkaz:
https://doaj.org/article/3404151324284798912a7963eaa667b8
Autor:
Sayani Dasgupta, Leandro M Castro, Russell Dulman, Ciyu Yang, Marion Schmidt, Emer S Ferro, Lloyd D Fricker
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e103604 (2014)
The proteasome cleaves intracellular proteins into peptides. Earlier studies found that treatment of human embryonic kidney 293T (HEK293T) cells with epoxomicin (an irreversible proteasome inhibitor) generally caused a decrease in levels of intracell
Externí odkaz:
https://doaj.org/article/a25220dad1ee422eb2cbd282a3f07f1c
Autor:
Julia S Gelman, Juan Sironi, Iryna Berezniuk, Sayani Dasgupta, Leandro M Castro, Fabio C Gozzo, Emer S Ferro, Lloyd D Fricker
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53263 (2013)
Bortezomib is an antitumor drug that competitively inhibits proteasome beta-1 and beta-5 subunits. While the impact of bortezomib on protein stability is known, the effect of this drug on intracellular peptides has not been previously explored. A qua
Externí odkaz:
https://doaj.org/article/1f7ffa509fdd4f1c90b0b1001dcb0b75
Autor:
Alberto Malvezzi, Patrícia M Higa, Antonia T-do Amaral, Gustavo M Silva, Fabio C Gozzo, Emer S Ferro, Leandro M Castro, Leandro de Rezende, Gisele Monteiro, Marilene Demasi
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39408 (2012)
Thimet oligopeptidase (EP24.15) is a cysteine-rich metallopeptidase containing fifteen Cys residues and no intra-protein disulfide bonds. Previous work on this enzyme revealed that the oxidative oligomerization of EP24.15 is triggered by S-glutathiol
Externí odkaz:
https://doaj.org/article/d1eb6ac02a524b949c397368b1d21451
Autor:
Luiz Felipe Martucci, Rosangela A.S. Eichler, Renée N.O. Silva, Tiago J. Costa, Rita C. Tostes, Geraldo F. Busatto, Marilia C.L. Seelaender, Alberto J.S. Duarte, Heraldo P. Souza, Emer S. Ferro
Publikováno v:
iScience, Vol 26, Iss 9, Pp 107542- (2023)
Summary: Intracellular peptides (InPeps) generated by the orchestrated action of the proteasome and intracellular peptidases have biological and pharmacological significance. Here, human plasma relative concentration of specific InPeps was compared b
Externí odkaz:
https://doaj.org/article/ed16d2f3b9724f018b9b9ae7854fda46
Autor:
Bruna Caprioli, Rosangela A. S. Eichler, Renée N. O. Silva, Luiz Felipe Martucci, Patricia Reckziegel, Emer S. Ferro
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 20, p 15190 (2023)
Neurolysin oligopeptidase (E.C.3.4.24.16; Nln), a member of the zinc metallopeptidase M3 family, was first identified in rat brain synaptic membranes hydrolyzing neurotensin at the Pro-Tyr peptide bond. The previous development of C57BL6/N mice with
Externí odkaz:
https://doaj.org/article/f31c80f4071b49eb8a49f0b6d63bda1e