Zobrazeno 1 - 10
of 204
pro vyhledávání: '"Emer S Ferro"'
Autor:
Luiz Felipe Martucci, Rosangela A.S. Eichler, Renée N.O. Silva, Tiago J. Costa, Rita C. Tostes, Geraldo F. Busatto, Marilia C.L. Seelaender, Alberto J.S. Duarte, Heraldo P. Souza, Emer S. Ferro
Publikováno v:
iScience, Vol 26, Iss 9, Pp 107542- (2023)
Summary: Intracellular peptides (InPeps) generated by the orchestrated action of the proteasome and intracellular peptidases have biological and pharmacological significance. Here, human plasma relative concentration of specific InPeps was compared b
Externí odkaz:
https://doaj.org/article/ed16d2f3b9724f018b9b9ae7854fda46
Autor:
Bruna Caprioli, Rosangela A. S. Eichler, Renée N. O. Silva, Luiz Felipe Martucci, Patricia Reckziegel, Emer S. Ferro
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 20, p 15190 (2023)
Neurolysin oligopeptidase (E.C.3.4.24.16; Nln), a member of the zinc metallopeptidase M3 family, was first identified in rat brain synaptic membranes hydrolyzing neurotensin at the Pro-Tyr peptide bond. The previous development of C57BL6/N mice with
Externí odkaz:
https://doaj.org/article/f31c80f4071b49eb8a49f0b6d63bda1e
Autor:
Joanna D.C.C. Lima, Estefania Simoes, Gabriela deCastro, Mychel Raony P.T. Morais, Emidio M. deMatos‐Neto, Michele J. Alves, Nelson I. Pinto, Raquel G. Figueredo, Telma M.T. Zorn, Aloísio S. Felipe‐Silva, Flavio Tokeshi, José P. Otoch, Paulo Alcantara, Fernanda J. Cabral, Emer S. Ferro, Alessandro Laviano, Marilia Seelaender
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 10, Iss 5, Pp 1045-1059 (2019)
Abstract Background Cachexia is a paraneoplastic syndrome related with poor prognosis. The tumour micro‐environment contributes to systemic inflammation and increased oxidative stress as well as to fibrosis. The aim of the present study was to char
Externí odkaz:
https://doaj.org/article/a2fd09ba02ec4f2b80d763ac0fc6bbe3
Autor:
Renata Silvério, Robson Barth, Andrea S. Heimann, Patrícia Reckziegel, Gustavo J. dos Santos, Silvana Y. Romero-Zerbo, Francisco J. Bermúdez-Silva, Alex Rafacho, Emer S. Ferro
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 8, p 4082 (2022)
Peptide DIIADDEPLT (Pep19) has been previously suggested to improve metabolic parameters, without adverse central nervous system effects, in a murine model of diet-induced obesity. Here, we aimed to further evaluate whether Pep19 oral administration
Externí odkaz:
https://doaj.org/article/587fa87c888e411c844176f89bb9ecf9
Autor:
Carolina A. Parada, Ivan Pires de Oliveira, Mayara C. F. Gewehr, João Agostinho Machado-Neto, Keli Lima, Rosangela A. S. Eichler, Lucia R. Lopes, Luiz R. G. Bechara, Julio C. B. Ferreira, William T. Festuccia, Luciano Censoni, Ivarne Luis S. Tersariol, Emer S. Ferro
Publikováno v:
Cells, Vol 11, Iss 3, p 385 (2022)
Intracellular peptides (InPeps) generated by proteasomes were previously suggested as putative natural regulators of protein–protein interactions (PPI). Here, the main aim was to investigate the intracellular effects of intracellular peptide VFDVEL
Externí odkaz:
https://doaj.org/article/0af4787aeba54bdd8849adf74bbaf058
Autor:
Renée N. O. Silva, Ricardo P. Llanos, Rosangela A. S. Eichler, Thiago B. Oliveira, Fábio C. Gozzo, William T. Festuccia, Emer S. Ferro
Publikováno v:
Pharmaceutics, Vol 13, Iss 12, p 2175 (2021)
Intracellular peptides were shown to derive from proteasomal degradation of proteins from mammalian and yeast cells, being suggested to play distinctive roles both inside and outside these cells. Here, the role of intracellular peptides previously id
Externí odkaz:
https://doaj.org/article/3234f191a26e40bbaeb3578faa9cb4f3
Autor:
Luiz Felipe Martucci, Rosangela A. S. Eichler, Tiago J. Costa, Rita C. Tostes, Geraldo F. Busatto, Marilia C.L. Seelaender, Alberto José da Silva Duarte, Heraldo Possolo de Sousa, Emer S. Ferro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb58ac2dd1f4aaa316236b1255c8524c
https://doi.org/10.2139/ssrn.4383075
https://doi.org/10.2139/ssrn.4383075
Thimet Oligopeptidase Biochemical and Biological Significances: Past, Present, and Future Directions
Publikováno v:
Biomolecules, Vol 10, Iss 9, p 1229 (2020)
Thimet oligopeptidase (EC 3.4.24.15; EP24.15, THOP1) is a metallopeptidase ubiquitously distributed in mammalian tissues. Beyond its previously well characterized role in major histocompatibility class I (MHC-I) antigen presentation, the recent chara
Externí odkaz:
https://doaj.org/article/34fb018298dc412b8e618cf73c010b01
Autor:
Mayara C. F. Gewehr, Renata Silverio, José Cesar Rosa-Neto, Fabio S. Lira, Patrícia Reckziegel, Emer S. Ferro
Publikováno v:
Molecules, Vol 25, Iss 5, p 1093 (2020)
Overweight and obesity are among the most prominent health problems in the modern world, mostly because they are either associated with or increase the risk of other diseases such as type 2 diabetes, hypertension, and/or cancer. Most professional org
Externí odkaz:
https://doaj.org/article/115b8e26b9364860bf6f0be8ff5b80f6
Autor:
Mayara C. F. Gewehr, Alexandre A. S. Teixeira, Bruna A. C. Santos, Luana A. Biondo, Fábio C. Gozzo, Amanda M. Cordibello, Rosangela A. S. Eichler, Patrícia Reckziegel, Renée N. O. Da Silva, Nilton B. Dos Santos, Niels O. S. Camara, Angela Castoldi, Maria L. M. Barreto-Chaves, Camila S. Dale, Nathalia Senger, Joanna D. C. C. Lima, Marilia C. L. Seelaender, Aline C. Inada, Eliana H. Akamine, Leandro M. Castro, Alice C. Rodrigues, José C. Rosa Neto, Emer S. Ferro
Publikováno v:
Biomolecules, Vol 10, Iss 2, p 321 (2020)
Thimet oligopeptidase (EC 3.4.24.15; EP24.15; THOP1) is a potential therapeutic target, as it plays key biological functions in processing biologically functional peptides. The structural conformation of THOP1 provides a unique restriction regarding
Externí odkaz:
https://doaj.org/article/cd23c3a4fd914795937480a86869742c