Zobrazeno 1 - 10
of 159
pro vyhledávání: '"Emer P, Reeves"'
Autor:
Oisin F. McElvaney, Takanori Asakura, Suzanne L. Meinig, Jose L. Torres-Castillo, Robert S. Hagan, Claudie Gabillard, Mark P. Murphy, Leigh B. Thorne, Alain Borczuk, Emer P. Reeves, Ross E. Zumwalt, Yu Mikami, Tomas P. Carroll, Kenichi Okuda, Grace Hogan, Oliver J. McElvaney, Jennifer Clarke, Natalie L. McEvoy, Patrick W. Mallon, Cormac McCarthy, Ger Curley, Matthew C. Wolfgang, Richard C. Boucher, Noel G. McElvaney
Publikováno v:
EBioMedicine, Vol 77, Iss , Pp 103894- (2022)
Summary: Background: Interleukin-6 (IL-6) is elevated in SARS-CoV-2 infection. IL-6 regulates acute-phase proteins, such as alpha-1 antitrypsin (AAT), a key lung anti-protease. We investigated the protease-anti-protease balance in the circulation and
Externí odkaz:
https://doaj.org/article/8689f1b6c49645dc94c1c385411f7c38
Autor:
Padraig Hawkins, Thomas McEnery, Claudie Gabillard-Lefort, David A. Bergin, Bader Alfawaz, Vipatsorn Shutchaidat, Paula Meleady, Michael Henry, Orla Coleman, Mark Murphy, Noel G. McElvaney, Emer P. Reeves
Publikováno v:
ERJ Open Research, Vol 7, Iss 4 (2021)
Oxidative stress from innate immune cells is a driving mechanism that underlies COPD pathogenesis. Individuals with α-1 antitrypsin (AAT) deficiency (AATD) have a dramatically increased risk of developing COPD. To understand this further, the aim of
Externí odkaz:
https://doaj.org/article/af089efb2deb4f1abed964d43721db1d
Autor:
Robin Caird, Michael Williamson, Azeez Yusuf, Debananda Gogoi, Michelle Casey, Noel G. McElvaney, Emer P. Reeves
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 12, p 6400 (2022)
In the lung, glycosaminoglycans (GAGs) are dispersed in the extracellular matrix (ECM) occupying the interstitial space between the capillary endothelium and the alveolar epithelium, in the sub-epithelial tissue and in airway secretions. In addition
Externí odkaz:
https://doaj.org/article/4924795d69214a859f5ae48ea939323e
Autor:
Elaine Hayes, Mark P. Murphy, Kerstin Pohl, Niall Browne, Karen McQuillan, Le Er Saw, Clare Foley, Fatma Gargoum, Oliver J. McElvaney, Padraig Hawkins, Cedric Gunaratnam, Noel G. McElvaney, Emer P. Reeves
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Studies have endeavored to understand the cause for impaired antimicrobial killing by neutrophils of people with cystic fibrosis (PWCF). The aim of this study was to focus on the bacterial phagosome. Possible alterations in degranulation of cytoplasm
Externí odkaz:
https://doaj.org/article/04ebfc8332b446b99afb537fda32bd8c
Autor:
Michael E. O’Brien, Grace Murray, Debananda Gogoi, Azeez Yusuf, Cormac McCarthy, Mark R. Wormald, Michelle Casey, Claudie Gabillard-Lefort, Noel G. McElvaney, Emer P. Reeves
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 5, p 2441 (2022)
Alpha-1 antitrypsin (AAT) is the canonical serine protease inhibitor of neutrophil-derived proteases and can modulate innate immune mechanisms through its anti-inflammatory activities mediated by a broad spectrum of protein, cytokine, and cell surfac
Externí odkaz:
https://doaj.org/article/e95866bc15ba4f818cf757bd848d6ef5
Autor:
Karen McQuillan, Fatma Gargoum, Mark P. Murphy, Oliver J. McElvaney, Noel G. McElvaney, Emer P. Reeves
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
In people with cystic fibrosis (PWCF), inflammation with concurrent infection occurs from a young age and significantly influences lung disease progression. Studies indicate that neutrophils are important effector cells in the pathogenesis of CF and
Externí odkaz:
https://doaj.org/article/5d94c2d258e641ff9bfca8b433698f42
Autor:
Danielle M. Clancy, Graeme P. Sullivan, Hannah B.T. Moran, Conor M. Henry, Emer P. Reeves, Noel G. McElvaney, Ed C. Lavelle, Seamus J. Martin
Publikováno v:
Cell Reports, Vol 22, Iss 11, Pp 2937-2950 (2018)
Summary: Neutrophil granule proteases are thought to function as anti-microbial effectors, cooperatively hydrolyzing microorganisms within phagosomes, or upon deployment into the extracellular space. However, evidence also suggests that neutrophil pr
Externí odkaz:
https://doaj.org/article/84b1f4ff03ca48e49b54d6cb7a3487cf
Autor:
Laura T. Fee, Debananda Gogoi, Michael E. O’Brien, Emer McHugh, Michelle Casey, Ciara Gough, Mark Murphy, Ann M. Hopkins, Tomás P. Carroll, Noel G. McElvaney, Emer P. Reeves
Publikováno v:
Biomedicines, Vol 9, Iss 12, p 1925 (2021)
Alpha-1 antitrypsin (AAT) deficiency (AATD) is characterized by increased risk for emphysema, chronic obstructive pulmonary disease (COPD), vasculitis, and wound-healing impairment. Neutrophils play a central role in the pathogenesis of AATD. Dysregu
Externí odkaz:
https://doaj.org/article/fd3974a57e8e4a62945b8c22bb67bc45
Publikováno v:
Medicina, Vol 57, Iss 8, p 814 (2021)
Background and Objectives: Alpha-1 antitrypsin is a serine protease inhibitor that demonstrates an array of immunomodulatory functions. Individuals with the genetic condition of alpha-1 antitrypsin deficiency (AATD) are at increased risk of early ons
Externí odkaz:
https://doaj.org/article/3a489638d0e64d8886128ee94ac89394
Autor:
Michelle M. White, Patrick Geraghty, Elaine Hayes, Stephen Cox, William Leitch, Bader Alfawaz, Gillian M. Lavelle, Oliver J. McElvaney, Ryan Flannery, Joanne Keenan, Paula Meleady, Michael Henry, Martin Clynes, Cedric Gunaratnam, Noel G. McElvaney, Emer P. Reeves
Publikováno v:
EBioMedicine, Vol 23, Iss C, Pp 173-184 (2017)
Background: Identification of mechanisms promoting neutrophil trafficking to the lungs of patients with cystic fibrosis (CF) is a challenge for next generation therapeutics. Cholesterol, a structural component of neutrophil plasma membranes influence
Externí odkaz:
https://doaj.org/article/4c254c6a5c004094adad2bd92a023cd1