Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Emelyne Diers"'
Autor:
Christiane Kofink, Nicole Trainor, Barbara Mair, Simon Wöhrle, Melanie Wurm, Nikolai Mischerikow, Michael J. Roy, Gerd Bader, Peter Greb, Géraldine Garavel, Emelyne Diers, Ross McLennan, Claire Whitworth, Vesna Vetma, Klaus Rumpel, Maximilian Scharnweber, Julian E. Fuchs, Thomas Gerstberger, Yunhai Cui, Gabriela Gremel, Paolo Chetta, Stefan Hopf, Nicole Budano, Joerg Rinnenthal, Gerhard Gmaschitz, Moriz Mayer, Manfred Koegl, Alessio Ciulli, Harald Weinstabl, William Farnaby
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Protein degraders are an emerging drug modality; however, their properties lie beyond typical drug-like space. Here the authors report optimisation via structure-based exit vector and linker design towards the VHL-recruiting PROTAC ACBI2, an orally b
Externí odkaz:
https://doaj.org/article/3f90550853c6402d8f154d10f8e2a18c
Autor:
Yurun Zhang, Martina Roos, Heather Himburg, Christina M. Termini, Mamle Quarmyne, Michelle Li, Liman Zhao, Jenny Kan, Tiancheng Fang, Xiao Yan, Katherine Pohl, Emelyne Diers, Hyo Jin Gim, Robert Damoiseaux, Julian Whitelegge, William McBride, Michael E. Jung, John P. Chute
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Protein tyrosine phosphatase sigma (PTPσ) deficient haematopoietic stem cells (HSCs) demonstrate increased engraftment following transplantation. Here the authors identify a small molecule inhibitor of PTPσ that promotes murine and human haematopoi
Externí odkaz:
https://doaj.org/article/a4cd7b0d3b6b453f9917108aabe1cec2
Autor:
Michelle Li, Liman Zhao, Heather A. Himburg, Tiancheng Fang, Yurun Zhang, Katherine Pohl, Martina Roos, Christina M. Termini, William H. McBride, Mamle Quarmyne, Robert Damoiseaux, Hyo Jin Gim, Michael E. Jung, Xiao Yan, John P. Chute, Julian P. Whitelegge, Emelyne Diers, Jenny Kan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature communications, vol 10, iss 1
Nature Communications
Nature communications, vol 10, iss 1
Receptor type protein tyrosine phosphatase-sigma (PTPσ) is primarily expressed by adult neurons and regulates neural regeneration. We recently discovered that PTPσ is also expressed by hematopoietic stem cells (HSCs). Here, we describe small molecu
Autor:
Simon Wöhrle, Tom Owen-Hughes, Jale Karolyi-Oezguer, Teresa Gmaschitz, Steffen Steurer, Bernadette Sharps, Heribert Arnhof, Gerd Bader, Joerg Rinnenthal, Thomas Gerstberger, Peter Greb, Manfred Koegl, Johannes Wachter, Michael Galant, Klaus Rumpel, Carina Riedmueller, William Farnaby, David Zollman, Peter Ettmayer, Meng-Ying Wu, Michael J. Roy, Emelyne Diers, Andreas Zoephel, Nicole Trainor, Darryl B. McConnell, Nicola Wiechens, Mark Pearson, Guido Boehmelt, Oliver Petermann, Alessio Ciulli, Renate Schnitzer, Harald Weinstabl, Christian Dank, Katharina Ehrenhöfer-Wölfer, Alexander Weiss-Puxbaum, Claire Whitworth, Elisabeth Traxler
Publikováno v:
Nature chemical biology
Targeting subunits of BAF/PBAF chromatin remodeling complexes has been proposed as an approach to exploit cancer vulnerabilities. Here, we develop proteolysis targeting chimera (PROTAC) degraders of the BAF ATPase subunits SMARCA2 and SMARCA4 using a
Publikováno v:
Angewandte Chemie. 126:3949-3952
Modulare 1,2,3-Triazole ermoglichten Eisen-katalysierte C-H-Arylierungen mit hoher Anwendungsbreite. Das neuartige Triazol-basierte, zweizahnige Auxiliar ist leicht zuganglich und bietet zudem eine benutzerfreundliche Eisen-katalysierte C(sp2)-H-Funk
Autor:
Jale Karolyi-Oezguer, Renate Schnitzer, Heribert Arnhof, Emelyne Diers, Andreas Zoephel, Harald Weinstabl, Bernadette Sharps, Darryl B. McConnell, Katharina Ehrenhöfer-Wölfer, Peter Ettmayer, David Zollman, Joerg Rinnenthal, Guido Boehmelt, Michael J. Roy, Meng-Ying Wu, Alessio Ciulli, Thomas Gerstberger, Klaus Rumpel, William Farnaby, Carina Riedmueller, Alexander Weiss-Puxbaum, Nicole Trainor, Peter Greb, Mark Pearson, Johannes Wachter, Michael Galant, Steffen Steurer, Tom Owen-Hughes, Oliver Petermann, Simon Wöhrle, Manfred Koegl, Nicola Wiechens, Elisabeth Traxler, Gerd Bader, Teresa Gmaschitz, Christian Dank, Claire Whitworth
Publikováno v:
Nature Chemical Biology. 15:846-846
In the version of this article originally published, several lines of text in the last paragraph of the right column on page 1 of the PDF were transposed into the bottom paragraph of the left column. The affected text of the left column should read "
Publikováno v:
Tetrahedron. 69:4445-4453
Carboxylate assistance was key to success for highly efficient ruthenium-catalyzed direct ortho-arylations of tetrazolyl-substituted arenes with aryl halides and triflates in the absence of phosphine ligands. Thus, ruthenium(II) biscarboxylates allow
Publikováno v:
ChemInform. 46
The direct arylation of amides is investigated in the presence of different side chain modifications and the triazole-based auxiliary -NH-Tam is found to be the optimal one.
Publikováno v:
ChemInform. 45
This method utilizes a triazole-derived auxiliary for the iron-catalyzed activation of otherwise inert C(sp2)—H and C(sp3)—H bonds.
Publikováno v:
Angewandte Chemie (International ed. in English). 53(15)
Modular 1,2,3-triazoles enabled iron-catalyzed CH arylations with broad scope. The novel triazole-based bidentate auxiliary is easily accessible in a highly modular fashion and allowed for user-friendly iron-catalyzed C(sp(2) )H functionalizati