Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Emelyn H. Shroff"'
Autor:
Phuoc T Tran, Emelyn H Shroff, Timothy F Burns, Saravanan Thiyagarajan, Sandhya T Das, Tahera Zabuawala, Joy Chen, Yoon-Jae Cho, Richard Luong, Pablo Tamayo, Tarek Salih, Khaled Aziz, Stacey J Adam, Silvestre Vicent, Carsten H Nielsen, Nadia Withofs, Alejandro Sweet-Cordero, Sanjiv S Gambhir, Charles M Rudin, Dean W Felsher
Publikováno v:
PLoS Genetics, Vol 8, Iss 5, p e1002650 (2012)
KRAS mutant lung cancers are generally refractory to chemotherapy as well targeted agents. To date, the identification of drugs to therapeutically inhibit K-RAS have been unsuccessful, suggesting that other approaches are required. We demonstrate in
Externí odkaz:
https://doaj.org/article/888bf29c10e84b71a81ce396c6901816
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e7059 (2009)
Nitric oxide (NO) activates the intrinsic apoptotic pathway to induce cell death. However, the mechanism by which this pathway is activated in cells exposed to NO is not known. Here we report that BAX and BAK are activated by NO and that cytochrome c
Externí odkaz:
https://doaj.org/article/6b16eb494f5e4fe5aa92006795e1edde
Autor:
Emelyn H Shroff, Colleen M Snyder, G R Scott Budinger, Manu Jain, Teng-Leong Chew, Satya Khuon, Harris Perlman, Navdeep S Chandel
Publikováno v:
PLoS ONE, Vol 4, Iss 5, p e5646 (2009)
BH3 only proteins trigger cell death by interacting with pro- and anti-apoptotic members of the BCL-2 family of proteins. Here we report that BH3 peptides corresponding to the death domain of BH3-only proteins, which bind all the pro-survival BCL-2 f
Externí odkaz:
https://doaj.org/article/708edc6482b84ab4ae41cd3394cc268d
Autor:
Vanessa M. Dang, David I. Bellovin, Stephanie C. Casey, Yulin Li, Emelyn H. Shroff, Meital Gabay, Phuoc T. Tran, Arvin M. Gouw, Adolfo Garcia-Ocaña, Dean W. Felsher, Stacey J. Adam, Richard N. Zare, William M. Philbrick, Chi V. Dang, Livia S. Eberlin
Publikováno v:
Oncotarget
The MYC oncogene is frequently mutated and overexpressed in human renal cell carcinoma (RCC). However, there have been no studies on the causative role of MYC or any other oncogene in the initiation or maintenance of kidney tumorigenesis. Here, we sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88f9e203c1713e8c756165a9558c13e8
https://doi.org/10.1073/pnas.1507228112
https://doi.org/10.1073/pnas.1507228112
Autor:
Emelyn H. Shroff, Richard H. Perry, Ali I. Ismail, David I. Bellovin, Dean W. Felsher, Tahera Zabuawala, Richard N. Zare
Publikováno v:
Analytical Chemistry. 85:4259-4262
We apply desorption electrospray ionization mass spectrometry imaging (DESI-MSI) to provide an in situ lipidomic profile of genetically modified tissues from a conditional transgenic mouse model of MYC-induced hepatocellular carcinoma (HCC). This uni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19ec6e2bd7a02d27bfce300024cc3872
https://doi.org/10.1021/ac400479j
https://doi.org/10.1021/ac400479j
Autor:
Emelyn H. Shroff, Tatyana A. Klimova, Paul T. Schumacker, Navdeep S. Chandel, Eric L. Bell, Frank Weinberg, G. R. Scott Budinger, Goberdan P. Dimri, Colleen M. Snyder
Publikováno v:
The FASEB Journal. 23:783-794
Senescence is a potential tumor-suppressing mechanism and a commonly used model of cellular aging. One current hypothesis to explain senescence, based in part on the correlation of oxygen with senescence, postulates that it is caused by oxidative dam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9988d92760d50e6e71383e1caac71c0
https://doi.org/10.1096/fj.08-114256
https://doi.org/10.1096/fj.08-114256
Publikováno v:
Antioxidants & Redox Signaling. 9:1405-1410
The mechanisms underlying anoxia (0-0.5% oxygen)-induced cell death are not fully understood. Here we discuss the mechanisms by which cells undergo apoptosis in the absence of oxygen. Cell death during anoxia occurs via the intrinsic pathway of apopt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4760e1c5f1debd94dcf9a533e47c022b
https://doi.org/10.1089/ars.2007.1731
https://doi.org/10.1089/ars.2007.1731
Autor:
Irina Budunova, Thomas Nelius, Alexander Yemelyanov, Olga V. Volpert, Wuhan Xiao, Zhou Wang, Dorina Veliceasa, Yelena Mirochnik, Stephanie Filleur, Emelyn H. Shroff, Arin B. Aurora
Publikováno v:
International Journal of Cancer. 121:999-1008
The androgen role in the maintenance of prostate epithelium is subject to conflicting opinions. While androgen ablation drives the regression of normal and cancerous prostate, testosterone may cause both proliferation and apoptosis. Several investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70b18f6ef126f0a410270d83e0ab744d
https://doi.org/10.1002/ijc.22802
https://doi.org/10.1002/ijc.22802
Autor:
Stephanie Filleur, Emelyn H. Shroff, Tetiana Zaichuk, Dorina Veliceasa, Yelena Mirochnik, Olga V. Volpert, S. P. Becerra, Hanhua Huang, Maria S. Aymerich, Karl Volz, Thomas Nelius, Ronald L. Yap
Publikováno v:
Cancer Research. 65:5144-5152
Pigment epithelial-derived factor (PEDF), an angiogenesis inhibitor with neurotrophic properties, balances angiogenesis in the eye and blocks tumor progression. Its neurotrophic function and the ability to block vascular leakage is replicated by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53723442fb556739595f8f0e792ddd83
https://doi.org/10.1158/0008-5472.can-04-3744
https://doi.org/10.1158/0008-5472.can-04-3744
Autor:
Hanhua Huang, Steven C. Campbell, Dhugal F. Bedford, Thomas Nelius, Dorina Veliceasa, Emelyn H. Shroff, Jack Henkin, Andrew Schneider, Noel Bouck, Olga V. Volpert
Publikováno v:
Molecular Cancer Research. 2:541-550
An expanding capillary network is critical for several pathologic conditions. In cancer, the decrease of antiangiogenic thrombospondin-1 (TSP1) often enables an angiogenic switch, which can be reversed with exogenous TSP1 or its peptide derivative AB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60be49907818439cebf25ed2d63d91b6
https://doi.org/10.1158/1541-7786.541.2.10
https://doi.org/10.1158/1541-7786.541.2.10