Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Emely Thompson"'
Autor:
Christopher I Murray, Maartje Westhoff, Jodene Eldstrom, Emely Thompson, Robert Emes, David Fedida
Publikováno v:
eLife, Vol 5 (2016)
Cardiac repolarization is determined in part by the slow delayed rectifier current (IKs), through the tetrameric voltage-gated ion channel, KCNQ1, and its β-subunit, KCNE1. The stoichiometry between α and β-subunits has been controversial with stu
Externí odkaz:
https://doaj.org/article/73646664f827455fb2c3f58e746d0331
Publikováno v:
Annual Review of Pharmacology and Toxicology. 61:381-400
Kv7 channels (Kv7.1–7.5) are voltage-gated K+ channels that can be modulated by five β-subunits (KCNE1–5). Kv7.1-KCNE1 channels produce the slow-delayed rectifying K+ current, IKs, which is important during the repolarization phase of the cardia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c580126f2e0ac9e4057040b1f76d58
https://doi.org/10.1146/annurev-pharmtox-010919-023645
https://doi.org/10.1146/annurev-pharmtox-010919-023645
Publikováno v:
Proceedings of the National Academy of Sciences. 116:7879-7888
The I Ks current has an established role in cardiac action potential repolarization, and provides a repolarization reserve at times of stress. The underlying channels are formed from tetramers of KCNQ1 along with one to four KCNE1 accessory subunits,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de8d6bc378a88649e296adc56c6209b5
https://doi.org/10.1073/pnas.1811623116
https://doi.org/10.1073/pnas.1811623116
Publikováno v:
Channels
The IKs current is important in the heart’s response to sympathetic stimulation. β-adrenergic stimulation increases the amount of IKs and creates a repolarization reserve that shortens the cardiac action potential duration. We have recently shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d19978acf15fdf8e22dc772e6164af23
http://europepmc.org/articles/PMC6986793
http://europepmc.org/articles/PMC6986793
Publikováno v:
The Journal of General Physiology
IKs channels are important for repolarization of cardiac action potentials during stress, but the mechanism has not been described microscopically. Thompson et al. show that cAMP facilitates voltage sensor activation in single channels, causing fewer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db6c3c5a20f719a104b8656ff8c4ec60
https://doi.org/10.1085/jgp.201611734
https://doi.org/10.1085/jgp.201611734
Publikováno v:
Biophysical Journal. 118:332a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31b321c5d94ecea183ba2ee846fcb1de
https://doi.org/10.1016/j.bpj.2019.11.1856
https://doi.org/10.1016/j.bpj.2019.11.1856
The delayed potassium rectifier current, I(Ks,) is assembled from tetramers of KCNQ1 and varying numbers of KCNE1 accessory subunits in addition to calmodulin. This channel complex is important in the response of the cardiac action potential to sympa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab788ebab67e92575878d9feb8eda379
https://europepmc.org/articles/PMC6224683/
https://europepmc.org/articles/PMC6224683/
Autor:
David Fedida, Jodene Eldstrom, Maartje Westhoff, Robert Emes, Emely Thompson, Christopher I. Murray
Publikováno v:
eLife
eLife, Vol 5 (2016)
eLife, Vol 5 (2016)
Cardiac repolarization is determined in part by the slow delayed rectifier current (IKs), through the tetrameric voltage-gated ion channel, KCNQ1, and its β-subunit, KCNE1. The stoichiometry between α and β-subunits has been controversial with stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3f762384cc6db87ed0e9947fa49502c
https://doi.org/10.7554/elife.11815
https://doi.org/10.7554/elife.11815
Publikováno v:
Biophysical Journal. 114:121a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70fc7eed8632cfd19e1245d46536e569
https://doi.org/10.1016/j.bpj.2017.11.694
https://doi.org/10.1016/j.bpj.2017.11.694