Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Emely A. Hoffman"'
Autor:
Marissa N. Trujillo, Erin Q. Jennings, Emely A. Hoffman, Hao Zhang, Aiden M. Phoebe, Grace E. Mastin, Naoya Kitamura, Julie A. Reisz, Emily Megill, Daniel Kantner, Mariola M. Marcinkiewicz, Shannon M. Twardy, Felicidad Lebario, Eli Chapman, Rebecca L. McCullough, Angelo D'Alessandro, Nathaniel W. Snyder, Darren A. Cusanovich, James J. Galligan
Publikováno v:
Molecular Metabolism, Vol 81, Iss , Pp 101888- (2024)
Chronic, systemic inflammation is a pathophysiological manifestation of metabolic disorders. Inflammatory signaling leads to elevated glycolytic flux and a metabolic shift towards aerobic glycolysis and lactate generation. This rise in lactate corres
Externí odkaz:
https://doaj.org/article/2715064b1deb49e1a938eed2068d8bb9
Autor:
Megan S. Molina, Emely A. Hoffman, Jessica Stokes, Nicole Kummet, Kyle A. Smith, Forrest Baker, Tiffany M. Zúñiga, Richard J. Simpson, Emmanuel Katsanis
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The growth factor Flt3 ligand (Flt3L) is central to dendritic cell (DC) homeostasis and development, controlling survival and expansion by binding to Flt3 receptor tyrosine kinase on the surface of DCs. In the context of hematopoietic cell transplant
Externí odkaz:
https://doaj.org/article/1fbaeb5f4a0b479b9e1dcceeba4ec585
Autor:
Megan S. Molina, Jessica Stokes, Emely A. Hoffman, Jelena Eremija, Yi Zeng, Richard J. Simpson, Emmanuel Katsanis
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Graft-versus-host disease (GvHD) remains the second leading cause of death in allogeneic hematopoietic stem cell transplantation recipients, highlighting the need for improved preventative strategies. Our laboratory has previously demonstrated in an
Externí odkaz:
https://doaj.org/article/2da1d3141269413a867040d1afb1e710
Autor:
Jessica Stokes, Emely A. Hoffman, Megan S. Molina, Nicole Kummet, Richard J. Simpson, Yi Zeng, Emmanuel Katsanis
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
Graft-versus-host disease (GvHD) remains a significant impediment to allogeneic hematopoietic cell transplantation (HCT) success, necessitating studies focused on alleviating GvHD, while preserving the graft-versus-leukemia (GvL) effect. Based on our
Externí odkaz:
https://doaj.org/article/8c47298d84304e3bb5d7e28e1db941c3
Autor:
Yi Zeng, Seongmin Hahn, Jessica Stokes, Emely A. Hoffman, Monika Schmelz, Maria Proytcheva, Jonathan Chernoff, Emmanuel Katsanis
Publikováno v:
Blood Advances, Vol 1, Iss 22, Pp 1923-1933 (2017)
Abstract: Myeloid-derived suppressor cells (MDSCs) are CD11b+Gr1+ cells that induce T-cell hyporesponsiveness, thus impairing antitumor immunity. We have previously reported that disruption of Pak2, a member of the p21-activated kinases (Paks), in he
Externí odkaz:
https://doaj.org/article/2cb25573e4aa43c38a47864819ec097a
Autor:
Megan S Molina, Emely A Hoffman, Jessica Stokes, Nicole Kummet, Richard J Simpson, Emmanuel Katsanis
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0273075 (2022)
The immediate precursor to murine type 1 conventional DCs (cDC1s) has recently been established and named "pre-cDC1s". Mature CD8α+ cDC1s are recognized for suppressing graft-versus-host disease (GvHD) while promoting graft-versus-leukemia (GvL), ho
Externí odkaz:
https://doaj.org/article/e1bcca6bae8a4868909e6057ef7845e3
Publikováno v:
Cancers, Vol 13, Iss 1702, p 1702 (2021)
Cancers
Cancers
Simple Summary Bendamustine is a chemotherapeutic agent used to treat a variety of cancers. It has recently been used in the context of allogeneic hematopoietic cell transplantation (HCT), a treatment mostly used to treat blood cancers. Given before
Autor:
Jessica Stokes, Cynthia J Doane, Emely A. Hoffman, David G. Besselsen, Emmanuel Katsanis, Karuna Patil
Publikováno v:
Comparative Medicine. 68:349-352
Multiple adult female CB6F1 mice presented with supernumerary incisors after preconditioning with chemotherapy and total body irradiation for bone marrow transplantation (BMT). Mice received nonmyeloablative total body irradiation (3 Gy) and either c
Autor:
Emmanuel Katsanis, Grace M. Niemiro, Emely A. Hoffman, Kyle A. Smith, Richard J. Simpson, Helena Batatinha, Forrest L. Baker
Publikováno v:
Medicine & Science in Sports & Exercise. 53:367-367
Autor:
Maria Proytcheva, Jessica Stokes, Seongmin Hahn, Yi Zeng, Emely A. Hoffman, Emmanuel Katsanis, Monika Schmelz, Jonathan Chernoff
Publikováno v:
Blood Advances. 1:1923-1933
Key Points Pak2 negatively regulates CD11bhighGr1high MDSC development in mice via both cell-intrinsic and extrinsic mechanisms. Pak2 disruption activates STAT5 while downregulating the expression of IRF8, a well-described myeloid transcription facto