Presence of type IIB procollagen in mouse articular cartilage and growth plate is revealed by immuno-histochemical analysis with a novel specific antibody

Autor: Emeline Perrier-Groult, Shérine Moustaghfir, Marielle Pasdeloup, Jean-Daniel Malcor, Jérôme Lafont, Frédéric Mallein-Gerin

Publikováno v: Matrix Biology Plus, Vol 18, Iss , Pp 100130- (2023)

Type II collagen is the major fibrillar collagen in cartilage. It is synthesized in the form of precursors (procollagens) containing N- and C-terminal propeptides. The two main isoforms of type II procollagen protein are type IIA and type IIB procoll

Externí odkaz: https://doaj.org/article/42d7056f7cbe47ea9ef8e0682d56cdbc

Direct Perfusion Improves Redifferentiation of Human Chondrocytes in Fibrin Hydrogel with the Deposition of Cartilage Pericellular Matrix

Autor: Alexandre Dufour, Frédéric Mallein-Gerin, Emeline Perrier-Groult

Publikováno v: Applied Sciences, Vol 11, Iss 19, p 8923 (2021)

Articular cartilage has limited potential for self-repair, and cell-based strategies combining scaffolds and chondrocytes are currently used to treat cartilage injuries. However, achieving a satisfying level of cell redifferentiation following expans

Externí odkaz: https://doaj.org/article/9c0d868128254d1db5d8a3f589ff7a09

Characterization of Different Sources of Human MSCs Expanded in Serum-Free Conditions with Quantification of Chondrogenic Induction in 3D

Autor: Hugo Fabre, Maxime Ducret, Olivier Degoul, Jonathan Rodriguez, Emeline Perrier-Groult, Elisabeth Aubert-Foucher, Marielle Pasdeloup, Céline Auxenfans, Colin McGuckin, Nico Forraz, Frédéric Mallein-Gerin

Publikováno v: Stem Cells International, Vol 2019 (2019)

Mesenchymal stem cells (MSCs) represent alternative candidates to chondrocytes for cartilage engineering. However, it remains difficult to identify the ideal source of MSCs for cartilage repair since conditions supporting chondrogenic induction are d

Externí odkaz: https://doaj.org/article/6f938b70fde247f3abbf677fb681a32d

ZAKβ is activated by cellular compression and mediates contraction-induced MAP kinase signaling in skeletal muscle

Autor: Cathrine Nordgaard, Anna Constance Vind, Amy Stonadge, Rasmus Kjøbsted, Goda Snieckute, Pedro Antas, Melanie Blasius, Marie Sofie Reinert, Ana Martinez Del Val, Dorte Breinholdt Bekker‐Jensen, Peter Haahr, Yekaterina A Miroshnikova, Abdelghani Mazouzi, Sarah Falk, Emeline Perrier‐Groult, Christopher Tiedje, Xiang Li, Jens Rithamer Jakobsen, Nicolas Oldenburg Jørgensen, Jørgen FP Wojtaszewski, Frederic Mallein‐Gerin, Jesper Løvind Andersen, Cristian Pablo Pennisi, Christoffer Clemmensen, Moustapha Kassem, Abbas Jafari, Thijn Brummelkamp, Vivian SW Li, Sara A Wickström, Jesper Velgaard Olsen, Gonzalo Blanco, Simon Bekker‐Jensen

Publikováno v: EMBO Journal
Nordgaard, C, Vind, A C, Stonadge, A, Kjøbsted, R, Snieckute, G, Antas, P, Blasius, M, Reinert, M S, Del Val, A M, Bekker-Jensen, D B, Haahr, P, Miroshnikova, Y A, Mazouzi, A, Falk, S, Perrier-Groult, E, Tiedje, C, Li, X, Jakobsen, J R, Jørgensen, N O, Wojtaszewski, J, Mallein-Gerin, F, Andersen, J L, Pennisi, C P, Clemmensen, C, Kassem, M, Jafari, A, Brummelkamp, T, Li, V S, Wickström, S A, Olsen, J V, Blanco, G & Bekker-Jensen, S 2022, ' ZAKβ is activated by cellular compression and mediates contraction-induced MAP kinase signaling in skeletal muscle ', E M B O Journal, vol. 41, no. 17, e111650 . https://doi.org/10.15252/embj.2022111650
Nordgaard, C, Vind, A C, Stonadge, A, Kjøbsted, R, Snieckute, G, Antas, P, Blasius, M, Reinert, M S, Del Val, A M, Bekker-Jensen, D B, Haahr, P, Miroshnikova, Y A, Mazouzi, A, Falk, S, Perrier-Groult, E, Tiedje, C, Li, X, Jakobsen, J R, Jørgensen, N O, Wojtaszewski, J F, Mallein-Gerin, F, Andersen, J L, Pennisi, C P, Clemmensen, C, Kassem, M, Jafari, A, Brummelkamp, T, Li, V S, Wickström, S A, Olsen, J V, Blanco, G & Bekker-Jensen, S 2022, ' ZAKβ is activated by cellular compression and mediates contraction-induced MAP kinase signaling in skeletal muscle ', The EMBO Journal, vol. 41, no. 17, e111650 . https://doi.org/10.15252/embj.2022111650

Mechanical inputs give rise to p38 and JNK activation, which mediate adaptive physiological responses in various tissues. In skeletal muscle, contraction-induced p38 and JNK signaling ensure adaptation to exercise, muscle repair, and hypertrophy. How

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::156c500b42a0371cbd16c762afce2461

Flow Cytometry Analysis of Type IIB Procollagen as Quality Control of Chondrogenic Commitment of MSCs

Autor: Hugo Fabre, Marielle Pasdeloup, Jérôme E. Lafont, Elisabeth Aubert-Foucher, Emeline Perrier-Groult, Frédéric Mallein-Gerin

Publikováno v: Stem Cells and Regenerative Medicine

Type II collagen is the major collagen protein in cartilage, synthesized as precursor forms (procollagens). Several splice variants of the gene encoding type II procollagen have been identified such as IIA and IIB isoforms. Interestingly, a shift fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c100d9ad94cabed42d8049ec34895396
https://doi.org/10.3233/bhr210008