Adenosine-Dependent Activation Mechanism of Prodrugs Targeting an Aminoacyl-tRNA Synthetase

Autor: Guillaume Hoffmann, Madalen Le Gorrec, Emeline Mestdach, Stephen Cusack, Loïc Salmon, Malene Ringkjøbing Jensen, Andrés Palencia

Publikováno v: Journal of the American Chemical Society
Journal of the American Chemical Society, 2023, 145 (2), pp.800-810. ⟨10.1021/jacs.2c04808⟩

Prodrugs have little or no pharmacological activity and are converted to active drugs in the body by enzymes, metabolic reactions, or through human-controlled actions. However, prodrugs promoting their chemical bioconversion without any of these proc

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https://hal.science/hal-04025430