Targeting demyelination via α-secretases promoting sAPPα release to enhance remyelination in central nervous system

Autor: Mehrnaz Jafarian-Tehrani, Anne Simon, Gemma Llufriu-Dabén, Christiane Rose, Jo Mailleux, Delphine Meffre, Emeline Camand, Bernadette Allinquant, Alex Carrete, Elena Chierto, Jerome J. A. Hendriks, Charbel Massaad, Tim Vanmierlo

Publikováno v: Neurobiology of Disease, Vol 109, Iss, Pp 11-24 (2018)

Remyelination is an endogenous regenerative process of myelin repair in the central nervous system (CNS) with limited efficacy in demyelinating disorders. As strategies enhancing endogenous remyelination become a therapeutic challenge, we have focuse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::270bd4fc57e885fa338b00cd1522477b
https://doi.org/10.1016/j.nbd.2017.09.008

Long-term changes in the molecular composition of the glial scar and progressive increase of serotoninergic fibre sprouting after hemisection of the mouse spinal cord

Autor: Marie-Pierre Morel, Emeline Camand, Isabelle Dusart, Constantino Sotelo, Andreas Faissner

Publikováno v: European Journal of Neuroscience
European Journal of Neuroscience, 2004, 20, pp.1161-1176. ⟨10.1111/j.1460-9568.2004.03558.x⟩
European Journal of Neuroscience, Wiley, 2004, 20, pp.1161-1176. ⟨10.1111/j.1460-9568.2004.03558.x⟩

The scarring process occurring after adult central nervous system injury and the subsequent increase in the expression of certain extracellular matrix molecules are known to contribute to the failure of axon regeneration. This study provides an immun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9fc9a8a9add6edf4f00e088b1b8b7eb
https://doi.org/10.1111/j.1460-9568.2004.03558.x

N-cadherin expression level modulates integrin-mediated polarity and strongly impacts on the speed and directionality of glial cell migration

Autor: Florent Peglion, Marc Sanson, Emeline Camand, Naël Osmani, Sandrine Etienne-Manneville

Publikováno v: Journal of Cell Science
Journal of Cell Science, 2012, 125 (4), pp.844-857. ⟨10.1242/jcs.087668⟩

International audience; Perturbation of cell polarity is a hallmark of cancer cells. In carcinomas, loss of epithelial E-cadherin contributes to the loss of cell polarity and promotes epithelial–mesenchymal transition and carcinoma infiltration. Ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b511c920ea35d8e43c20720a00b43e21
https://hal-pasteur.archives-ouvertes.fr/pasteur-03521577/file/844.pdf

Classical cadherins control nucleus and centrosome position and cell polarity

Autor: Isabelle Dupin, Emeline Camand, Sandrine Etienne-Manneville

Publikováno v: The Journal of Cell Biology

Control of cell polarity is crucial during tissue morphogenesis and renewal, and depends on spatial cues provided by the extracellular environment. Using micropatterned substrates to impose reproducible cell–cell interactions, we show that in the a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70f29177deba4e93beb1fdb360cf7a10
https://pubmed.ncbi.nlm.nih.gov/19487453

Cell death and axon regeneration of Purkinje cells after axotomy: challenges of classical hypotheses of axon regeneration

Autor: Rosine Wehrlé, Marie-Pierre Morel, Abdel M. Ghoumari, Emeline Camand, Lamia Bouslama-Oueghlani, Constantino Sotelo, Isabelle Dusart

Publikováno v: Brain Research Brain research reviews.
Brain Research Brain research reviews., 2005, 49, pp.300-316. ⟨10.1016/j.brainresrev.2004.11.007⟩

Although adult mammalian neurons are able to regenerate their axons in the peripheral nervous system under certain conditions, they are not able to do it in the central nervous system. The environment surrounding the severed axons appears to be a key

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::381291efe82ca1e3d907bcf4131e54fc
https://hal.archives-ouvertes.fr/hal-00081002