Profiling spatiotemporal gene expression of the developing human spinal cord and implications for ependymoma origin

Autor: Xiaofei Li, Zaneta Andrusivova, Paulo Czarnewski, Christoffer Mattsson Langseth, Alma Andersson, Yang Liu, Daniel Gyllborg, Emelie Braun, Ludvig Larsson, Lijuan Hu, Zhanna Alekseenko, Hower Lee, Christophe Avenel, Helena Kopp Kallner, Elisabet Åkesson, Igor Adameyko, Mats Nilsson, Sten Linnarsson, Joakim Lundeberg, Erik Sundström

Publikováno v: Nature Neuroscience. 26:891-901

The spatiotemporal regulation of cell fate specification in the human developing spinal cord remains largely unknown. In this study, by performing integrated analysis of single-cell and spatial multi-omics data, we used 16 prenatal human samples to c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b23766a58ea8fb330107437388f1985
https://doi.org/10.1038/s41593-023-01312-9

Comprehensive cell atlas of the first-trimester developing human brain

Autor: Emelie Braun, Miri Danan-Gotthold, Lars E. Borm, Elin Vinsland, Ka Wai Lee, Peter Lönnerberg, Lijuan Hu, Xiaofei Li, Xiaoling He, Žaneta Andrusivová, Joakim Lundeberg, Ernest Arenas, Roger A. Barker, Erik Sundström, Sten Linnarsson

The adult human brain likely comprises more than a thousand kinds of neurons, and an unknown number of glial cell types, but how cellular diversity arises during early brain development is not known. Here, in order to reveal the precise sequence of e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d32487403753b503bd14210a256a1e5d
https://doi.org/10.1101/2022.10.24.513487

Developmental origins of cell heterogeneity in the human lung

Autor: Alexandros Sountoulidis, Sergio Marco Salas, Emelie Braun, Christophe Avenel, Joseph Bergenstråhle, Marco Vicari, Paulo Czarnewski, Jonas Theelke, Andreas Liontos, Xesus Abalo, Žaneta Andrusivová, Michaela Asp, Xiaofei Li, Lijuan Hu, Sanem Sariyar, Anna Martinez Casals, Burcu Ayoglu, Alexandra Firsova, Jakob Michaëlsson, Emma Lundberg, Carolina Wählby, Erik Sundström, Sten Linnarsson, Joakim Lundeberg, Mats Nilsson, Christos Samakovlis

SummaryThe lung contains numerous specialized cell-types with distinct roles in tissue function and integrity. To clarify the origins and mechanisms generating cell heterogeneity, we created a first comprehensive topographic atlas of early human lung

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::368d5772de9c95b032ea21d46393bbb0
https://doi.org/10.1101/2022.01.11.475631

Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells

Autor: Kamil Slowikowski, Nathan R. Tucker, William Zhao, Alex Sountoulidis, Ross J. Metzger, Allon Zaneta Andrusivova, Marie Deprez, Lolita Penland, Wendy Luo, Sijia Chen, Gökcen Eraslan, Peng Tan, Jessica Tantivit, Monika Litviňuková, Lisa Sikkema, Kyungtae Lim, Hananeh Aliee, Rachel Queen, Alexi McAdams, Brian M. Lin, Michal Slyper, Astrid Gillich, Christopher Smilie, Karthik A. Jagadeesh, Liam Bolt, Christoph Muus, Hattie Chung, Jian Shu, Yoshihiko Kobayashi, Lira Mamanova, Arun C. Habermann, Pascal Barbry, Eeshit Dhaval Vaishnav, Mark Chaffin, Sergio Poli, Malte D Luecken, Xiaomeng Hou, Alok Jaiswal, Rene Sit, Inbal Benhar, Charles-Hugo Marquette, Maximilian Strunz, Christin S. Kuo, Evgenij Fiskin, Thomas M. Conlon, Meshal Ansari, Cancan Qi, Rahul Sinha, Ji Lu, Austin J. Gutierrez, Daniel Reichart, Michael Leney-Greene, Olivier Poirion, Peng He, Tyler Harvey, David Fischer, Neal Smith, Evgeny Chichelnitskiy, Ilias Angelidis, Carlos Talavera-López, Kasidet Manakongtreecheep, Marc Wadsworth, Christophe Bécavin, Kevin Bassler, Kyle J. Travaglini, Graham Heimberg, Dawei Sun, Adam L. Haber, Joshua Gould, Elena Torlai Triglia, Ayshwarya Subramanian, Jonas C. Schupp, Ivan O. Rosas, Leif S. Ludwig, Ian Mbano, Taylor Adams, J. Samuel, Michael S. Cuoco, Carly Ziegler, Lijuan Hu, Avinash Waghray, Joseph Bergenstråhle, Ludvig Larsson, Elizabeth Thu Duong, Julia Waldman, Ludvig Bergenstråhle, Joshua Chiou, Sarah K. Nyquist, Minzhe Guo, Peiwen Cai, Daniel T. Montoro, Peiyong Jiang, Orr Ashenberg, Elo Madissoon, Emelie Braun, Justin Buchanan, Ahmad N. Nabhan, Katherine A. Vernon, Linh T. Bui, Theodoros Kapellos, Wenjun Yan, Henrike Maatz, Xiuting Wang

The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, creates an urgent need for identifying molecular mechanisms that mediate viral entry, propagation, and tissue pathology. Cell membrane bound angiotensin-converting enzyme 2 (ACE2) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c2714ad434c64a22ead6b22cc40d01a
https://doi.org/10.1101/2020.04.19.049254

HGG-06. EARLY GABAERGIC NEURONAL LINEAGE DEFINES DEPENDENCIES IN HISTONE H3 G34R/V GLIOMA

Autor: Sameer Agnihotri, Joshua M. Dempster, Li Jiang, Erik Sundstroem, Johannes Gojo, Olivia A Hack, Christine Haberler, Kristina A. Cole, Miri Danan-Gotthold, McKenzie Shaw, Ed S. Lein, Yura Grabovska, Gustavo Alencastro Veiga Cruzeiro, Samantha E Hoffman, Ilon Liu, Christian Dorfer, Sanda Alexandrescu, Sara Temelso, Bernhard Englinger, Valeria Molinari, Christopher Rota, Lynn Bjerke, Chris Jones, Sten Linnarsson, René Geyeregger, Lisa Mayr, Irene Slavc, Cristina Bleil, Hafsa M Mire, Angela Waanders, Tara Barron, Angela Mastronuzzi, Gerda Ricken, Eshini Panditharatna, Kimberly Siletti, Lijuan Hu, Alan L. Mackay, Simon R. Stapleton, Michelle Monje, Emelie Braun, Michael Quezada, Mariella G. Filbin, David D Eisenstat, Sibylle Madlener, Maria Vinci, Rebecca Hodge, Fernando Carceller, Angel M. Carcaboso, Darren Hargrave, Rebecca Rogers

Publikováno v: Neuro-Oncology

High-grade gliomas harboring H3 G34R/V mutations exclusively occur in the cerebral hemispheres of adolescents and young adults, suggesting a distinct neurodevelopmental origin. Combining multimodal bulk and single-cell genomics with unbiased genome-s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::551e267607ee523125c91b043551e069
http://europepmc.org/articles/PMC8168148