IL-1β promotes adipogenesis by directly targeting adipocyte precursors

Autor: Kaisa Hofwimmer, Joyce de Paula Souza, Narmadha Subramanian, Milica Vujičić, Leila Rachid, Hélène Méreau, Cheng Zhao, Erez Dror, Emelie Barreby, Niklas K. Björkström, Ingrid Wernstedt Asterholm, Marianne Böni-Schnetzler, Daniel T. Meier, Marc Y. Donath, Jurga Laurencikiene

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)

Abstract Postprandial IL-1β surges are predominant in the white adipose tissue (WAT), but its consequences are unknown. Here, we investigate the role of IL-1β in WAT energy storage and show that adipocyte-specific deletion of IL-1 receptor 1 (IL1R1

Externí odkaz: https://doaj.org/article/ba5db9b693c1401681bcd5953d8aed76

Macrophage functional diversity in NAFLD — more than inflammation

Autor: Emelie Barreby, Ping Chen, Myriam Aouadi

Publikováno v: Nature Reviews Endocrinology. 18:461-472

Macrophages have diverse phenotypes and functions due to differences in their origin, location and pathophysiological context. Although their main role in the liver has been described as immunoregulatory and detoxifying, changes in macrophage phenoty

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b1fab2feaeab36340ea5ef50e93b971
https://doi.org/10.1038/s41574-022-00675-6

Human resident liver macrophages protect against metabolic stress in obesity

Autor: Emelie Barreby, Benedikt Strunz, Valerio Azzimato, Joanne X. Shen, Léa Naudet, Isabella Sönnerborg, André Sulen, Sebastian Nock, Laura Levi, Cecilia Morgantini, Achilleas Fardellas, Helene Johansson, Greg Nowak, Per Stal, Ewa Ellis, Erik Naslund, Volker Lauschke, Niklas Björkström, Ping Chen, Myriam Aouadi

Publikováno v: Journal of Hepatology. 77:S756-S757

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a1d56bbe9ee4a60a56036fc32c005fff
https://doi.org/10.1016/s0168-8278(22)01829-3

A subset of Kupffer cells regulates metabolism through the expression of CD36

Autor: Guochen Wan, Nicholas Ang, Shanshan W. Howland, Svetoslav Chakarov, Evan W. Newell, Gregoire Gessain, Wan Ting Kong, Cecilia Morgantini, Olivier N. F. Cexus, Bernett Lee, Zhaoyuan Liu, Xenia Ficht, Ping Chen, Giorgia De Simone, Emelie Barreby, Josephine Lum, Nicolas Venteclef, Francesco Andreata, Ahad Khalilnezhad, Myriam Aouadi, Jinmiao Chen, Connie Xu, Xiaomeng Zhang, Ivy Low, Foo Shihui, Garett Dunsmore, Anis Larbi, Laurent Yvan-Charvet, Camille Blériot, Wei Guo, Rhea Pai, Muhammad Faris Bin Mohd Kairi, Benoit Malleret, Radoslaw M. Sobota, Wint Wint Phoo, Florent Ginhoux, Lai Guan Ng, Valerio Azzimato, Marc Bajénoff, Raphaelle Ballaire, Matteo Iannacone, Valeria Fumagalli, Ankur Sharma, Akhila Balachander

Publikováno v: Immunity
Immunity, 2021, 54 (9), pp.2101-2116.e6. ⟨10.1016/j.immuni.2021.08.006⟩
Immunity, Elsevier, 2021, 54 (9), pp.2101-2116.e6. ⟨10.1016/j.immuni.2021.08.006⟩

Tissue macrophages are immune cells whose phenotypes and functions are dictated by origin and niches. However, tissues are complex environments, and macrophage heterogeneity within the same organ has been overlooked so far. Here, we used high-dimensi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23490336ad2977228391058cd537e043
https://hal.science/hal-03818742

Liver macrophages inhibit the endogenous antioxidant response in obesity-associated insulin resistance

Autor: Joost Willerbrords, Siobhan M. Craige, Joanne X. Shen, Lars Haag, André Sulen, Ping Chen, Volker M. Lauschke, Erik Näslund, Cecilia Morgantini, Emelie Barreby, Jennifer Jager, Robin P. Choudhury, Ewa Ellis, Mikael Rydén, Xidan Li, Myriam Aouadi, Laura Levi, Anders Thorell, Connie Xu, Valerio Azzimato, Naveed Akbar, Carolina Oses, Kerstin Wålhen

Obesity and insulin resistance are risk factors for nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disease worldwide. Because no approved medication nor an accurate and noninvasive diagnosis is currently available for NAFLD,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f75c302bd3885e3c4076b8286adb5faf
https://hdl.handle.net/10919/101849