Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Emel Girit"'
Autor:
Emel Girit, Rachel Humphrey, Francis Y. Lee, Gregg Masters, Gennaro Dito, Maria Jure-Kunkel, John T. Hunt
Publikováno v:
Cancer Immunology, Immunotherapy
Ipilimumab, a cytotoxic T-lymphocyte antigen-4 (CTLA-4) binding agent, has proven to be an effective monotherapy for metastatic melanoma and has shown antitumor activity in trials when administered with other therapeutic agents. We hypothesized that
Autor:
Christopher R. Yonan, Jun-Hsiang Lin, Laura J. Hefta, Emel Girit, Ralph Abraham, Shan Gao, Maria Jure-Kunkel, Donna M. Dambach, Shen-Jue Chen, William R. Foster
Publikováno v:
Veterinary immunology and immunopathology. 126(3-4)
CD137 plays an important role as a co-stimulatory molecule in activated T cells. Agonistic CD137 specific antibodies have been investigated as therapeutic agents to promote tumor-specific immune responses by direct activation of T cells. As part of t