Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Emel Ficici"'
Autor:
Emel Ficici, José D. Faraldo-Gómez, Robyn Stix, Hassane S. Mchaourab, Osamu Nureki, Derek P. Claxton, Steven Castellano, Wenchang Zhou, Tsukasa Kusakizako
Publikováno v:
The Journal of Biological Chemistry
In both prokaryotes and eukaryotes, multidrug and toxic-compound extrusion (MATE) transporters catalyze the efflux of a broad range of cytotoxic compounds, including human-made antibiotics and anticancer drugs. MATEs are secondary-active antiporters,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::669cc8f65e9478a69f98f57e59ddbe7a
https://pubmed.ncbi.nlm.nih.gov/33402425
https://pubmed.ncbi.nlm.nih.gov/33402425
Autor:
Andrew Hutchin, Pierre Legrand, Matthieu Masureel, Cédric Govaerts, Emel Ficici, José Jd Faraldo-Gómez, Chloe Martens, Hassane S. Mchaourab, Richard A. Stein, Vincent Debruycker, Han Remaut
Publikováno v:
Nature structural & molecular biology
Nat Struct Mol Biol
Nat Struct Mol Biol
Multidrug efflux pumps present a challenge to the treatment of bacterial infections, making it vitally important to understand their mechanism of action. Here, we investigate the nature of substrate binding within Lactococcus lactis LmrP, a prototypi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01dee958c64eace009c45e9cbe779f00
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/310051
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/310051
Publikováno v:
Biophysical Journal. 121:253a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cef29c21b59ba7ab21363620cbb7591f
https://doi.org/10.1016/j.bpj.2021.11.1511
https://doi.org/10.1016/j.bpj.2021.11.1511
Publikováno v:
Journal of General Physiology. 149:1149-1164
The membrane transporter anion exchanger 1 (AE1), or band 3, is a key component in the processes of carbon-dioxide transport in the blood and urinary acidification in the renal collecting duct. In both erythrocytes and the basolateral membrane of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9091caf3f59add6a9f33314b1b6ee05b
https://doi.org/10.1085/jgp.201711836
https://doi.org/10.1085/jgp.201711836
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 115(27)
MATE transporters deplete the bacterial cytosol of natural and human-made antibiotics and contribute to confer multidrug resistance to a wide range of human pathogens. Despite being a compelling pharmacological target, little is known about their mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4c046fc6c5bab7e8bef6893c618933dd
https://pubmed.ncbi.nlm.nih.gov/29915058
https://pubmed.ncbi.nlm.nih.gov/29915058
Publikováno v:
Proceedings of the National Academy of Sciences. 115
Multidrug and toxic-compound extrusion (MATE) proteins comprise an important but largely uncharacterized family of secondary-active transporters. In both eukaryotes and prokaryotes, these transporters protect the cell by catalyzing the efflux of a br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1815433f5c896b15fa2c334aae2d50c
https://doi.org/10.1073/pnas.1802080115
https://doi.org/10.1073/pnas.1802080115
Publikováno v:
Biophysical Journal. 116:554a-555a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed7b8273b6058d92fb1df304d9fee4e9
https://doi.org/10.1016/j.bpj.2018.11.2982
https://doi.org/10.1016/j.bpj.2018.11.2982
Publikováno v:
Biophysical journal, vol 112, iss 12
SecDF is an important component of the Sec protein translocation machinery embedded in the bacterial membrane, which is associated with many functions, such as stabilizing other Sec translocon components within the membrane, maintaining the transmemb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63012134c9f98a309be728939edbe1a4
https://pubmed.ncbi.nlm.nih.gov/28636909
https://pubmed.ncbi.nlm.nih.gov/28636909
Publikováno v:
Biophysical Journal. 114:331a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fb24afecb8b6f0ac51435b9a913e6e5
https://doi.org/10.1016/j.bpj.2017.11.1857
https://doi.org/10.1016/j.bpj.2017.11.1857
Publikováno v:
Biophysical Journal. 114:333a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::015fe3ddfbbfad237c8315746dd3ef0c
https://doi.org/10.1016/j.bpj.2017.11.1864
https://doi.org/10.1016/j.bpj.2017.11.1864