Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Emel Adaligil"'
Autor:
Juan Hu, Alix I Chan, Emel Adaligil, Ivy Kekessie, Mifune Takahashi, Aimin Song, Christian N. Cunningham, Brian M. Paegel
Publikováno v:
Journal of Medicinal Chemistry. 66:6288-6296
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25660f2143f10e27703c822d080f42a3
https://doi.org/10.1021/acs.jmedchem.3c00138
https://doi.org/10.1021/acs.jmedchem.3c00138
Publikováno v:
ACS Chemical Biology. 16:1325-1331
Herein, we report the ribosomal elongation of linear γ4- and β-hydroxy-γ4-amino acids (statines) to expand the nonproteinogenic amino acid repertoire of natural product-like combinatorial peptide libraries. First, we demonstrated the successful ri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db8c5fae979a57d9733f4893f651d75a
https://doi.org/10.1021/acschembio.1c00292
https://doi.org/10.1021/acschembio.1c00292
Autor:
Emel Adaligil, Wayne J. Fairbrother
Publikováno v:
ACS Symposium Series ISBN: 9780841297616
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18c8c5d1c99c120532059b435c6f9f04
https://doi.org/10.1021/bk-2022-1417.ch006
https://doi.org/10.1021/bk-2022-1417.ch006
Autor:
Aimin Song, Emel Adaligil, Christian N. Cunningham, Wayne J. Fairbrother, Kenneth K. Hallenbeck
Publikováno v:
ACS Chemical Biology. 16:1011-1018
The development of large, natural-product-like, combinatorial macrocyclic peptide libraries is essential in the quest to develop therapeutics for "undruggable" cellular targets. Herein we report the ribosomal synthesis of macrocyclic peptides contain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4159be97fe249f8ce4f338e626cd515b
https://doi.org/10.1021/acschembio.1c00062
https://doi.org/10.1021/acschembio.1c00062
Autor:
Peter S. Dragovich, Mingtao He, Leanna Staben, Hongyan Zhang, Melinda M. Mulvihill, Catherine Wilson, Hao Zhou, Tracy Kleinheinz, Binqing Wei, Jianfeng Xin, Nicole Blaquiere, Fanwei Meng, John S. Wai, Susan Kaufman, Liang Liu, Rebecca K. Rowntree, Steven T. Staben, Jing Wang, Katherine R. Kozak, Josefa dela Cruz-Chuh, Zijin Xu, Steven J. Hartman, Robert A. Blake, Xiaoyu Zhu, Sunil Bhakta, Donglu Zhang, Hui Yao, Aimee O'Donohue, Jack Sadowsky, Qi Liu, Pragya Adhikari, Liling Liu, Ying Lu, Thomas H. Pillow, Jinhua Chen, Emel Adaligil, Karen E. Gascoigne
Publikováno v:
Journal of Medicinal Chemistry. 64:2534-2575
The biological and medicinal impacts of proteolysis-targeting chimeras (PROTACs) and related chimeric molecules that effect intracellular degradation of target proteins via ubiquitin ligase-mediated ubiquitination continue to grow. However, these chi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eaea12dee6f95904b15f4c9e925d0b1
https://doi.org/10.1021/acs.jmedchem.0c01845
https://doi.org/10.1021/acs.jmedchem.0c01845
Autor:
Emel, Adaligil, Aimin, Song, Kenneth K, Hallenbeck, Christian N, Cunningham, Wayne J, Fairbrother
Publikováno v:
ACS chemical biology. 16(6)
The development of large, natural-product-like, combinatorial macrocyclic peptide libraries is essential in the quest to develop therapeutics for "undruggable" cellular targets. Herein we report the ribosomal synthesis of macrocyclic peptides contain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b0eaa4e7b7eafacbc4d1a0373002a1e4
https://pubmed.ncbi.nlm.nih.gov/34008946
https://pubmed.ncbi.nlm.nih.gov/34008946
Autor:
Steven J. Hartman, Ying Lu, Wentao Wei, Hao Zhou, Geoffrey Del Rosario, Robert A. Blake, Xiaoyu Zhu, Nicholas Corr, Aaron Fullerton, Shang-Fan Yu, Peter S. Dragovich, Jing Wang, Rebecca K. Rowntree, Donglu Zhang, Hui Yao, Emel Adaligil, Fan Jiang, Hongyan Zhang, Jack Sadowsky, John S. Wai, Jinhua Chen, Thomas H. Pillow, Susan Kaufman, Zijin Xu, Katherine R. Kozak, Jeremy Murray, Shenhua Zhang, Leanna Staben, Josefa dela Cruz-Chuh, Pragya Adhikari, Aimee O'Donohue, Tracy Kleinheinz, Liling Liu, Melinda M. Mulvihill, William S. Sawyer, Yongxin Zhao, Binqing Wei
Publikováno v:
Journal of medicinal chemistry. 64(5)
Heterobifunctional compounds that direct the ubiquitination of intracellular proteins in a targeted manner via co-opted ubiquitin ligases have enormous potential to transform the field of medicinal chemistry. These chimeric molecules, often termed pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::519ca8bb4de4ed4b24ce14fe281e518e
https://pubmed.ncbi.nlm.nih.gov/33596073
https://pubmed.ncbi.nlm.nih.gov/33596073
Autor:
Swapnil V. Ghodge, Kaustav Biswas, Andrei A. Golosov, Tomi K. Sawyer, Christina Helmling, Christian N. Cunningham, Vikram K. Mulligan, Parisa Hosseinzadeh, Dan Sindhikara, Jennifer Johnston, Anna Sophia Kamenik, Stephanie Maria Linker, Sereina Riniker, Emel Adaligil, Wayne J. Fairbrother, Dehua Pei, Alec N. Flyer, Lauren G. Monovich, Amy C. Doty, Cassie M. Jarvis, Erik V. Munsell, Ruchia Duggal, Jerome Hochman
Publikováno v:
ACS chemical biology. 14(7)
A paucity of viable programs and pipelines for the discovery of new antibiotics poses a significant public health threat. The emergence of resistant strains against vancomycin is particularly dangerous in hospital settings. Here, we report the design
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::889c2b4260d40f3546462f89810a0028
https://pubmed.ncbi.nlm.nih.gov/31243959
https://pubmed.ncbi.nlm.nih.gov/31243959
Autor:
Emel Adaligil, Krzysztof Slowinski
Publikováno v:
Journal of Electroanalytical Chemistry. 649:142-148
The effect of aliphatic alcohols (1-pentanol, 1-hexanol, 2-hexanol, and 1-heptanol) on the rates of electrochemical electron tunneling across monolayers of n-alkanethiols (CH3(CH2)n–SH, n = 8, 9, 11) self-assembled on an expandable hanging mercury
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08269299f9304535572a137994593174
https://doi.org/10.1016/j.jelechem.2010.02.018
https://doi.org/10.1016/j.jelechem.2010.02.018