Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Emeka Ifedigbo"'
Autor:
Tamás Dolinay, Wei Wu, Naftali Kaminski, Emeka Ifedigbo, A Murat Kaynar, Mária Szilasi, Simon C Watkins, Stefan W Ryter, Alexander Hoetzel, Augustine M K Choi
Publikováno v:
PLoS ONE, Vol 3, Iss 2, p e1601 (2008)
Mechanical ventilation causes ventilator-induced lung injury in animals and humans. Mitogen-activated protein kinases have been implicated in ventilator-induced lung injury though their functional significance remains incomplete. We characterize the
Externí odkaz:
https://doaj.org/article/5b0d6ab14f5b479eb57c4ae4493f91ce
Autor:
So-Jin Kim, Feng Wan, Maor Sauler, Emeka Ifedigbo, Lin Leng, Richard Bucala, Patty J. Lee, Yi Zhang, Xuchen Zhang
Publikováno v:
The FASEB Journal. 34:1-1
Autor:
Sung Soo Jung, Kiichi Nakahira, Augustine M.K. Choi, Jin Fu Xu, Stefan W. Ryter, Jong Seok Moon, Emeka Ifedigbo
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 308:L1058-L1067
Inflammasomes are cytosolic protein complexes that promote the cleavage of caspase-1, which leads to the maturation and secretion of proinflammatory cytokines, including interleukin-1β (IL-1β) and IL-18. Among the known inflammasomes, the nucleotid
Autor:
Hilaire C. Lam, Chang Hyeok An, Xiaomei Wang, Augustine M.K. Choi, Stefan W. Ryter, George R. Washko, Emeka Ifedigbo
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 303:L748-L757
Toll-like receptors (TLRs) exert important nonimmune functions in lung homeostasis. TLR4 deficiency promotes pulmonary emphysema. We examined the role of TLR4 in regulating cigarette smoke (CS)-induced autophagy, apoptosis, and emphysema. Lung tissue
Autor:
Augustine M.K. Choi, Joshua A. Englert, Rahamthulla S. Shaik, Emeka Ifedigbo, Kiichi Nakahira, Tamas Dolinay, Jeffrey A. Haspel
Publikováno v:
Autophagy. 7:629-642
Macroautophagy is a highly conserved catabolic process that is crucial for organ homeostasis in mammals. However, methods to directly measure macroautophagic activity (or flux) in vivo are limited. In this study we developed a quantitative macroautop
Autor:
Justin J Choi, Jayashree Rao, Erin Curtis, Michael A. Mathier, Mark T. Gladwin, Philip M. Bauer, Brian S. Zuckerbraun, Kevin P. Mollen, Augustine M.K. Choi, Emeka Ifedigbo, Sruti Shiva
Publikováno v:
Circulation. 121:98-109
Background— Pulmonary arterial hypertension is a progressive proliferative vasculopathy of the small pulmonary arteries that is characterized by a primary failure of the endothelial nitric oxide and prostacyclin vasodilator pathways, coupled with d
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 297:L945-L953
Hyperoxia-induced lung injury is an established model that mimics human acute respiratory distress syndrome. Cell death is a prominent feature in lungs following prolonged hyperoxia. Caveolae are omega-shaped invaginations of the plasma membrane. Cav
Autor:
Yingze Zhang, Alexander Hoetzel, Rene Schmidt, Augustine M.K. Choi, Hong Pyo Kim, Stefan W. Ryter, A. Murat Kaynar, Emeka Ifedigbo, Simone Vallbracht, Tamas Dolinay, Sean Alber
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 177:1223-1232
Ventilator-induced lung injury (VILI) leads to an unacceptably high mortality. In this regard, the antiinflammatory properties of inhaled carbon monoxide (CO) may provide a therapeutic option.This study explores the mechanisms of CO-dependent protect
Autor:
Kathleen G. Raman, Edith Tzeng, Brett A. Ozanich, Emeka Ifedigbo, Joel E. Barbato, Leo E. Otterbein, Mazen S. Zenati
Publikováno v:
Journal of Vascular Surgery. 44:151-158
ObjectiveCarbon monoxide (CO) and nitric oxide (NO) have both been shown to possess vasoprotective properties. NO has successfully inhibited intimal hyperplasia in both small-animal and large-animal experimental models, whereas CO has only been studi
Autor:
Vincent J. Carey, Jeffrey A. Haspel, Vanessa Process, Laura E. Fredenburgh, Joshua A. Englert, Sukrutha Chettimada, Emeka Ifedigbo, James A. Lederer, Anna Coronata, Rahamthulla S. Shaik, Ashley Pelton, Benjamin A. Raby, Manuela Cernadas, Augustine M.K. Choi, Jen-Hwa Chu, G Matthew Hunninghake
Publikováno v:
Nature communications
Circadian rhythms are known to regulate immune responses in healthy animals, but it is unclear whether they persist during acute illnesses where clock gene expression is disrupted by systemic inflammation. Here we use a genome-wide approach to invest