Výsledky vyhledávání - "Emeka EJ Iweala"

Akademický článek

Acute oral toxicity and antimalarial studies of 7-[(7-methoxy-4,5-dihydro-1H-benzo[g]indazol-3-yl)carbonyl]-2-phenyl-5,6,7,8-tetrahydropyrazolo[1,5-a]pyrido[4,3-d]pyrimidin-9(1H)-one in mouse models

Autor: David O Oladejo, Titilope M Dokunmu, Mercy E Tebamifor, Mercy B Omunagbe, Esther O Okafor, Emeka EJ Iweala

Publikováno v: Scientific African, Vol 24, Iss , Pp e02194- (2024)

Reports of resistance to current antimalarial combination therapies (ACTs) have necessitated the discovery of new antimalarial drugs, most importantly with new mechanisms of action. From our molecular docking study, the small molecule 7-[(7-methoxy-4

Externí odkaz: https://doaj.org/article/9b630cc78921435fa8675a4e416fdf6d

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Akademický článek

Gene expression levels and inhibitory effect of 7-[(7-methoxy-4,5-dihydro-1H-benzo[g]indazol-3-yl)carbonyl]-2-phenyl-5,6,7,8-tetrahydropyrazolo[1,5-a]pyrido[4,3-d]Pyrimidin-9(1H)-one (MCL) against AP2-I and BDP1 in malaria experimental models

Autor: David O Oladejo, Dorathy O Anzaku, Collins O Mamudu, Temitope Elugbadebo, Titilope M Dokunmu, Ezekiel F Adebiyi, Emeka EJ Iweala

Publikováno v: Scientific African, Vol 23, Iss , Pp e02010- (2024)

Resistance to antimalarial drugs leads a global recurrence of malaria, posing a significant challenge to malaria control. This study aimed to assess gene expression and resistance profiles in clinical isolates, and validate the inhibitory effect of M

Externí odkaz: https://doaj.org/article/64d4ba2e8afa4d75a1d3af7964311e94

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Akademický článek

Structure Prediction, Molecular Docking, and Dynamic Simulation of AP2-I Transcription Factor

Autor: David O Oladejo, Gbolahan O Oduselu, Titilope M Dokunmu, Itunuoluwa Isewon, Jelili Oyelade, Esther Okafor, Emeka EJ Iweala, Ezekiel Adebiyi

Publikováno v: Bioinformatics and Biology Insights, Vol 17 (2023)

Plasmodium falciparum Apicomplexan Apetala 2 Invasion ( Pf AP2-I) transcription factor (TF) is a protein that regulates the expression of a subset of gene families involved in P. falciparum red blood cell (RBC) invasion. Inhibiting Pf AP2-I TF with s

Externí odkaz: https://doaj.org/article/276d00e541bd4915a01737a1737370c7

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In silico Structure Prediction, Molecular Docking, and Dynamic Simulation of Plasmodium falciparum AP2-I Transcription Factor

Autor: David O Oladejo, Gbolahan O Oduselu, Titilope M Dokunmu, Itunuoluwa Isewon, Jelili Oyelade, Esther Okafor, Emeka EJ Iweala, Ezekiel Adebiyi

Publikováno v: Bioinformatics and Biology Insights. 17:117793222211496

Plasmodium falciparum Apicomplexan Apetala 2 Invasion ( PfAP2-I) transcription factor (TF) is a protein that regulates the expression of a subset of gene families involved in P. falciparum red blood cell (RBC) invasion. Inhibiting PfAP2-I TF with sma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c470895e1d2a029fb846a9ff2bfc6ae8
https://doi.org/10.1177/11779322221149616

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Abstract 3903: Acute toxicity studies of ethanolic fruit-skin extract of Annona muricata

Autor: Wisdom Iyanda-Joel, Sandra O. Israel-Ovirih, Shalom Nwodo Chinedu, Emeka Ej Iweala

Publikováno v: Cancer Research. 79:3903-3903

Recent reports have shown that the currently high demand for Annona muricata fruits and plant products is most likely due to their selective cytotoxic activity, where extracts and subsequent pure compounds exhibited more toxicity to cancer cell lines

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ff46cb0a5a8ca3499cd970fc6448d4ab
https://doi.org/10.1158/1538-7445.am2019-3903

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