Zobrazeno 1 - 10 of 89 pro vyhledávání: '"Embryonic Stem Cells/Induced Pluripotent Stem Cells"'
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CRISPR editing of the GLI1 first intron abrogates GLI1 expression and differentially alters lineage commitment
Autor: Philip M. Iannaccone, Joon Won Yoon, Xenia A. Glukhova, Xiao-Nan Li, Robert L. Taylor, Yekaterina Galat, Mariana Perepitchka, Igor P. Beletsky, Vasiliy Galat, David O. Walterhouse, Haigang Gu
Publikováno v: Stem Cells (Dayton, Ohio)
GLI1 is one of three GLI family transcription factors that mediate Sonic Hedgehog signaling, which plays a role in development and cell differentiation. GLI1 forms a positive feedback loop with GLI2 and likely with itself. To determine the impact of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb707fcb6d2ca6ecc418973e827f88c1
https://doi.org/10.1002/stem.3341
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3
Directed induction of alveolar type I cells derived from pluripotent stem cells via Wnt signaling inhibition
Autor: Shimpei Gotoh, Satoshi Ikeo, Yutaka Suzuki, Masahide Seki, Takahiro Suezawa, Shuhei Kanagaki, Yuki Yamamoto, Masatoshi Hagiwara, Toyohiro Hirai
Publikováno v: Stem Cells (Dayton, Ohio)
Alveologenesis is a developmental step involving the expansion of the lung surface area which is essential for gas exchange. The gas exchange process is mediated by alveolar type I (AT1) cells, which are known to be differentiated from alveolar type
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34cd30bae123ae9b6414d150df4b5904
https://doi.org/10.1002/stem.3302
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4
Reprogramming progressive cells display low CAG promoter activity
Autor: Xinyue Chen, Anna E. Eastman, In-Hyun Park, Amaleah A. Hartman, Xiao Hu, Qiao Wu, Jonghun Kim, Jian Zhang, Shangqin Guo
Publikováno v: Stem Cells (Dayton, Ohio)
There is wide variability in the propensity of somatic cells to reprogram into pluripotency in response to the Yamanaka factors. How to segregate these variabilities to enrich for cells of specific traits that reprogram efficiently remains challengin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd170abeca35b447a14b69e2604c2fee
https://doi.org/10.1002/stem.3295
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5
Accelerated differentiation of human pluripotent stem cells into neural lineages via an early intermediate ectoderm population
Autor: James R. Dutton, Vincent Truong, Walter C. Low, Patrick J. Walsh, Sushmita Nayak, Marietta Saldías Montivero, Ann M. Parr
Publikováno v: Stem Cells (Dayton, Ohio)
Differentiation of human pluripotent stem cells (hPSCs) into ectoderm provides neurons and glia useful for research, disease modeling, drug discovery, and potential cell therapies. In current protocols, hPSCs are traditionally differentiated into an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1ef02c12a1569f9cac36b7735362ede
https://doi.org/10.1002/stem.3260
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6
Mapping developmental trajectories and subtype diversity of normal and glaucomatous human retinal ganglion cells by single‐cell transcriptome analysis
Autor: Iqbal Ahmad, Meng Niu, Pooja Teotia
Publikováno v: Stem Cells (Dayton, Ohio)
Glaucoma is characterized by a progressive degeneration of retinal ganglion cells (RGCs), leading to irreversible vision loss. Currently, there is no effective treatment for RGC degeneration. We used a disease‐in‐a‐dish stem cell model to exami
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d16a3b16767e86841f7c15369e436f9
http://europepmc.org/articles/PMC7586941
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7
Sphingosine kinases protect murine embryonic stem cells from sphingosine-induced cell cycle arrest
Autor: Kelly M. Banks, Duancheng Wen, Andrew Kuo, Ritu Kumar, Todd Evans, Suveg Pandey, Timothy Hla
Publikováno v: Stem Cells (Dayton, Ohio)
Sphingosine‐1‐phosphate (S1P) is a bioactive lipid molecule regulating organogenesis, angiogenesis, cell proliferation, and apoptosis. S1P is generated by sphingosine kinases (SPHK1 and SPHK2) through the phosphorylation of ceramide‐derived sph
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a5146ee2df2f6a1c036aac93127167
https://doi.org/10.1002/stem.3145
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8
MicroRNA-124a inhibits endoderm lineage commitment by targeting Sox17 and Gata6 in mouse embryonic stem cells
Autor: Hitoshi Nakagama, Lee Chuen Liew, Yusuke Yamamoto, Luc Gailhouste, Fumitaka Takeshita, Takahiro Ochiya, Geok Chin Tan
Publikováno v: Stem Cells (Dayton, Ohio)
The role of microRNAs (miRNAs) during mouse early development, especially in endoderm germ layer formation, is largely unknown. Here, via miRNA profiling during endoderm differentiation, we discovered that miR‐124a negatively regulates endoderm lin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42aabe175f6ef15501d1111120720fa8
https://doi.org/10.1002/stem.3136
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10
Developing a simple method to enhance the generation of cone and rod photoreceptors in pluripotent stem cell-derived retinal organoids
Autor: Majed Felemban, Yuchun Ding, Natalio Krasnogor, Birthe Dorgau, Ali E. Ghareeb, Darin Zerti, Min Yu, Majlinda Lako
Publikováno v: Stem Cells (Dayton, Ohio)
Cell replacement therapy is a promising treatment for irreversible retinal cell death in diverse diseases such as Stargardt's disease, age‐related macular degeneration, and retinitis pigmentosa. The final impact of all retinal dystrophies is the lo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afccece1844a2be8193888bcc55438b4
https://doi.org/10.1002/stem.3082
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