Výsledky vyhledávání - "Embryonic Stem Cells/Induced Pluripotent Stem (iPS) Cells"

Multicolor Staining of Globin Subtypes Reveals Impaired Globin Switching During Erythropoiesis in Human Pluripotent Stem Cells

Autor: Koji Eto, Tatsutoshi Nakahata, Shoichi Hirose, Hiromitsu Nakauchi, Naoya Takayama, Kiyosumi Ochi

Publikováno v: Stem Cells Translational Medicine. 3:792-800

Adult hemoglobin composed of α- and β-globin reflects a change from expression of embryonic ε- and fetal γ-globin to adult β-globin in human erythroid cells, so-called globin switching. Human pluripotent stem cells (hPSCs) are a potential source

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c948400a40945afeb8f4f94ce7ef5115
https://doi.org/10.5966/sctm.2013-0216

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Increased Genomic Integrity of an Improved Protein-Based Mouse Induced Pluripotent Stem Cell Method Compared With Current Viral-Induced Strategies

Autor: Mi Yoon Chang, Sanghyeok Ko, Paulo Sng Man Yoo, Jeong Tae Do, Robert Lanza, Chengsheng Zhang, Kwang Soo Kim, Rebecca C. Iskow, Dohoon Kim, Min-Joon Han, Chun-Hyung Kim, Hansoo Park, Eun Gyo Lee, Ryan E. Mills, Hyun Woo Choi, Jung Il Moon, Joon Ki Jung

Publikováno v: Stem Cells Translational Medicine. 3:599-609

It has recently been shown that genomic integrity (with respect to copy number variants [CNVs]) is compromised in human induced pluripotent stem cells (iPSCs) generated by viral-based ectopic expression of specific transcription factors (e.g., Oct4,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f8ca94cf019147078d852bbdfd8c93c
https://doi.org/10.5966/sctm.2013-0149

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Chemically Induced Specification of Retinal Ganglion Cells From Human Embryonic and Induced Pluripotent Stem Cells

Autor: Hamidreza Riazifar, Gary Lynch, Jing Chen, Yousheng Jia, Taosheng Huang

Publikováno v: Riazifar, H; Jia, Y; Chen, J; Lynch, G; & Huang, T. (2014). Chemically induced specification of retinal ganglion cells from human embryonic and induced pluripotent stem cells. Stem Cells Translational Medicine, 3(4), 424-432. doi: 10.5966/sctm.2013-0147. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/88f2s80h

The loss of retinal ganglion cells (RGCs) is the primary pathological change for many retinal degenerative diseases. Although there is currently no effective treatment for this group of diseases, cell transplantation to replace lost RGCs holds great

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb56a035aff17b4da9709018294f20c6
https://doi.org/10.5966/sctm.2013-0147

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Myogenic Differentiation of Muscular Dystrophy-Specific Induced Pluripotent Stem Cells for Use in Drug Discovery

Autor: Kevin Lai, Thuy Ai Huyen Le, Monica Bennett, Bahram Valamehr, Peter Flynn, David J. Robbins, Tom Tong Lee, Ramzey Abujarour, Megan Robinson

Publikováno v: Stem Cells Translational Medicine. 3:149-160

Human induced pluripotent stem cells (iPSCs) represent a scalable source of potentially any cell type for disease modeling and therapeutic screening. We have a particular interest in modeling skeletal muscle from various genetic backgrounds; however,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af8d53b64ad2906d1741bb66fcd17ed5
https://doi.org/10.5966/sctm.2013-0095

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Messenger RNA- Versus Retrovirus-Based Induced Pluripotent Stem Cell Reprogramming Strategies: Analysis of Genomic Integrity

Autor: Noushin Dianat, Inmaculada Moreno-Gimeno, Eléanor Luce, Anne Dubart-Kupperschmitt, Gérard Tachdjian, Joëlle Marie, Clara Steichen, Lucie Tosca, Jérome Maluenda, Deborah J. Burks, Christophe Desterke, Judith Melki, Sylvie Goulinet-Mainot, Sarah Awan-Toor, Anne Weber

Publikováno v: Stem Cells Translational Medicine
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
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The use of synthetic messenger RNAs to generate human induced pluripotent stem cells (iPSCs) is particularly appealing for potential regenerative medicine applications, because it overcomes the common drawbacks of DNA-based or virus-based reprogrammi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91942aa5c29f66c97ae603704f6872f3

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Influence of In Vitro and In Vivo Oxygen Modulation on β Cell Differentiation From Human Embryonic Stem Cells

Autor: Susana Villate, Camillo Ricordi, R. D. Molano, Christopher A. Fraker, Antonello Pileggi, Silvia Álvarez-Cubela, Luca Inverardi, Sirlene Cechin, Jaime A. Giraldo, Juan Domínguez-Bendala

Publikováno v: Stem Cells Translational Medicine. 3:277-289

The possibility of using human embryonic stem (hES) cell-derived β cells as an alternative to cadaveric islets for the treatment of type 1 diabetes is now widely acknowledged. However, current differentiation methods consistently fail to generate me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2e884e894662cf9076c87fba9e4e55b
https://doi.org/10.5966/sctm.2013-0160

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Small Molecule-Mediated Directed Differentiation of Human Embryonic Stem Cells Toward Ventricular Cardiomyocytes

Autor: Chi-Wing Kong, Deborah K. Lieu, Roger J. Hajjar, Francesca Stillitano, Grant Senyei, Lihuan Ren, Ioannis Karakikes, Evren U. Azeloglu, Ravi Iyengar, Jiaxian Wang, Jens Hansen, Jean-Sébastien Hulot, Ronald A. Li

Publikováno v: Stem Cells Translational Medicine. 3:18-31

The generation of human ventricular cardiomyocytes from human embryonic stem cells and/or induced pluripotent stem cells could fulfill the demand for therapeutic applications and in vitro pharmacological research; however, the production of a homogen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efdd4c799d067576093fc2f7bfa80b27
https://doi.org/10.5966/sctm.2013-0110

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Expansive Generation of Functional Airway Epithelium From Human Embryonic Stem Cells

Autor: Brendan A.S. McIntyre, Borhane Guezguez, Rami Mechael, Mickie Bhatia, Aline Fiebig-Comyn, Yuping Wu, Kyle R. Salci, Jung Bok Lee, Guojun Sheng, Cantas Alev

Publikováno v: Stem Cells Translational Medicine. 3:7-17

Production of human embryonic stem cell (hESC)-derived lung progenitors has broad applicability for drug screening and cell therapy; however, this is complicated by limitations in demarcating phenotypic changes with functional validation of airway ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52d351a55f74b2dfcf02f1bd09aa722c
https://doi.org/10.5966/sctm.2013-0119

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Zinc Finger Nuclease-Expressing Baculoviral Vectors Mediate Targeted Genome Integration of Reprogramming Factor Genes to Facilitate the Generation of Human Induced Pluripotent Stem Cells

Autor: Rui-Zhe Phang, Wee Kiat Tan, Han Chong Toh, Johan Chin-Kang Tay, Felix Chang Tay, Zhendong Li, Sal-Lee Goh, Cia-Hin Lau, Haibao Zhu, Can Chen, Shouhui Du, Weimin Fan, Chunxiao Wu, Shu Wang, Jieming Zeng, Qingle Liang

Publikováno v: Stem Cells Translational Medicine. 2:935-945

Integrative gene transfer using retroviruses to express reprogramming factors displays high efficiency in generating induced pluripotent stem cells (iPSCs), but the value of the method is limited because of the concern over mutagenesis associated wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87692140c008d4085bd42e97a10f4b4a
https://doi.org/10.5966/sctm.2013-0043

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Mouse Embryonic Stem Cells Established in Physiological-Glucose Media Express the High KM Glut2 Glucose Transporter Expressed by Normal Embryos

Autor: Mary R. Loeken, Xiao Dan Wang, Jin Hyuk Jung

Publikováno v: Stem Cells Translational Medicine. 2:929-934

Glut2 is one of the facilitative glucose transporters expressed by preimplantation and early postimplantation embryos. Glut2 is important for survival before embryonic day 10.5. The Glut2 KM (∼16 mmol/liter) is significantly higher than physiologic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2353fa07ce1f50771648c3ad16de94d1
https://doi.org/10.5966/sctm.2013-0093

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